Abstract: An application, in preparation of medicine for preventing or treating a disease related to a tyrosine kinase, of a compound as represented by formula I, or a pharmaceutically acceptable salt, an ester, a solvate, a prodrug, an active metabolite, a crystal, a stereoisomer, a tautomer, or a geometric isomer thereof, or a pharmaceutical composition comprising the compound as represented by formula I or the pharmaceutically acceptable salt, ester, solvate, prodrug, active metabolite, crystal, stereoisomer, tautomer, or geometric isomer thereof.