Patents by Inventor Daiji Naka

Daiji Naka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody to hepatocyte growth factor activator inhibitor-1 and use thereof
    Patent number: 7087391
    Abstract: A hybridoma is selected that produces a monoclonal antibody exhibiting high reactivity to soluble hepatocyte growth factor activator inhibitor-1 (soluble HAI-1), the target monoclonal antibody is prepared from culture supernatant of the obtained hybridoma, and by using the antibody soluble HAI-1 is measured.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: August 8, 2006
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Toshiya Yamagishi, Daiji Naka, Kazuhiro Nagaike
  • Specific antibody directed to active hepatocyte growth factor activator and method for using the same
    Patent number: 7045602
    Abstract: An antibody which recognizes an active hepatocyte growth factor activator (HGFA) and does not substantially recognize inactive HGFA is provided. Also disclosed is a monoclonal antibody thereof, and a hybridoma cell line for producing the monoclonal antibody. There is further provided a method for measuring active HGFA using the antibody, and a method for detecting a disease, by detecting or measuring active HGFA using the antibody.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: May 16, 2006
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Daiji Naka, Kazuhiko Nagaike
  • Specific antibody directed to active hepatocyte growth factor activator and method for using the same
    Publication number: 20060073520
    Abstract: An antibody which recognizes an active hepatocyte growth factor activator (HGFA) and does not substantially recognize inactive HGFA is provided. Also disclosed is a monoclonal antibody thereof, and a hybridoma cell line for producing the monoclonal antibody. There is further provided a method for measuring active HGFA using the antibody, and a method for detecting a disease, by detecting or measuring active HGFA using the antibody.
    Type: Application
    Filed: September 29, 2005
    Publication date: April 6, 2006
    Inventors: Daiji Naka, Kazuhiko Nagaike
  • Antibody to hepatocyte growth factor activator inhibitor-1 and use thereof
    Publication number: 20030064420
    Abstract: A hybridoma is selected that produces a monoclonal antibody exhibiting high reactivity to soluble hepatocyte growth factor activator inhibitor-1 (soluble HAT-1), the target monoclonal antibody is prepared from culture supernatant of the obtained hybridoma, and by using the antibody soluble HAI-1 is measured.
    Type: Application
    Filed: May 24, 2002
    Publication date: April 3, 2003
    Inventors: Toshiya Yamagishi, Daiji Naka, Kazuhiro Nagaike
  • Specific antibody directed to active hepatocyte growth factor activator and method for using the same
    Publication number: 20020165362
    Abstract: An antibody which recognizes an active hepatocyte growth factor activator (HGFA) and does not substantially recognize inactive HGFA is provided. Also disclosed is a monoclonal antibody thereof, and a hybridoma cell line for producing the monoclonal antibody. There is further provided a method for measuring active HGFA using the antibody, and a method for detecting a disease, by detecting or measuring active HGFA using the antibody.
    Type: Application
    Filed: December 4, 2001
    Publication date: November 7, 2002
    Inventors: Daiji Naka, Kazuhiko Nagaike
  • Method of inhibiting the degradation of hepatocyte growth factor
    Patent number: 5736506
    Abstract: A method for inhibiting the degradation of a hepatocyte-growth factor (HGF) which comprises combining at least one polysaccharide or a derivative thereof with a hepatocyte-growth factor (HGF) is disclosed. The polysaccharides include heparin, hyaluronic acid, dextran, dextran sulfate, heparan sulfate, dermatan sulfate, keratan sulfate, chondroitin, and chondroitin sulfate.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: April 7, 1998
    Assignee: Mitsubishi Kasei Corporation
    Inventor: Daiji Naka
  • Hepatocyte-growth agent
    Patent number: 5545722
    Abstract: Disclosed is a hepatocyte-growth agent which comprises a polysaccharide or a derivative such as heparin, heparan sulfate, chondroitin sulfate and dextran sulfate and a hepatocyte-growth factor (hHGF) obtained by purification of plasma or recombination, by which activity of the hHGF is strengthened, and an hHGF molecule is stabilized.
    Type: Grant
    Filed: August 19, 1994
    Date of Patent: August 13, 1996
    Assignee: Mitsubishi Kasei Corporation
    Inventor: Daiji Naka
  • Hepatic parenchymal cell growth factor gene encoding the same, process for producing the factor and transformants producing the factor
    Patent number: 5500354
    Abstract: According to the present invention, there are provided hepatic parenchymal cell growth factor obtained by recombinant DNA technology, a gene coding for the factor, an expression vector capable of expressing the gene, a cell, in particular animal cell, transformed with the expression vector, and a process for producing the hepatic parenchymal cell growth factor.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: March 19, 1996
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Naomi Kitamura, Keiji Miyazawa, Yasushi Daikuhara, Hirohito Tsubouchi, Daiji Naka, Kazuhiro Takahashi, Rie Matsui, Yoshiko Yoshiyama, Takehisa Ishii