Abstract: The pressurizing device includes a syringe configured to store a fluid, a plunger for discharging the fluid to the outside of the syringe when the plunger moves to one side in a first direction, a regulating member configured to move in a second direction intersecting the first direction, between a separated position of being separated from the plunger and a contact position of being in contact with the plunger, a lever configured to move the regulating member from the contact position to the separated position, and a rotation mechanism provided at a position overlapping with the regulating member in the second direction, configured to move in the second direction in accordance with rotation of the lever, and configured to move, when moving to one side in the second direction, the regulating member from the contact position to the separated position.

Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.

Abstract: This disclosure provides a novel lyophilized formulation that incorporates a surfactant solution to stabilize the Sabin inactivated polio vaccine and demonstrate the vaccine efficacy in an in vivo challenge model. Furthermore, SE-HPLC analysis of D-antigen content in in inactivated polio vaccine can be used to provide a method for high throughput evaluation of inactivated poliovirus stability.