Patents by Inventor Daiki Nagamatsu

Daiki Nagamatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES
    Publication number: 20190002420
    Abstract: The present invention provides a process for preparation of the compound of formula (VI), wherein each symbol is as defined in the specification, without using any intermediate compound showing mutagenicity. The process comprises salt formation of the intermediate compound of formula (I) with acid to enable optical resolution to isolate the intermediate compound of formula (II) in a stereo-selective manner.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 3, 2019
    Applicant: Shionogi & Co., Ltd.
    Inventors: Naohiro ONODERA, Kouichi NOGUCHI, Shigeru ANDO, Daiki NAGAMATSU, Kenichi ISHIBASHI, Shunsuke OCHI, Aiko HASEGAWA, Katsuo ODA
  • Salt of cephalosporin derivative, its crystalline solid and a method of manufacturing thereof
    Patent number: 10004750
    Abstract: The present invention provides an acid addition salt or a sodium salt of a compound represented by the formula (IA): or their hydrate or a stable crystalline solid thereof. The salt or the crystalline solid is extremely useful as an active ingredient for the production of a pharmaceutical product.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: June 26, 2018
    Assignee: Shionogi & Co., Ltd.
    Inventors: Fumihiko Matsubara, Takanori Kurita, Daiki Nagamatsu
  • A SALT OF CEPHALOSPORIN DERIVATIVE, ITS CRYSTALLINE SOLID AND A METHOD OF MANUFACTURING THEREOF
    Publication number: 20170281638
    Abstract: The present invention provides an acid addition salt or a sodium salt of a compound represented by the formula (IA): or their hydrate or a stable crystalline solid thereof. The salt or the crystalline solid is extremely useful as an active ingredient for the production of a pharmaceutical product.
    Type: Application
    Filed: September 3, 2015
    Publication date: October 5, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Fumihiko MATSUBARA, Takanori KURITA, Daiki NAGAMATSU
  • Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
    Patent number: 9365587
    Abstract: The invention is a process for the preparation of a compound of the following formula (I): wherein R is —CHO, —CH(OH)2 or —CH(OH)(OR4); P1 is H or a hydroxyl protecting group; P3 is H or a carboxy protecting group; R3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; Rx is H, halogen or R2—X—NR1—C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: June 14, 2016
    Assignees: SHIONOGI & CO., LTD., ViiV HEALTHCARE COMPANY
    Inventors: Hiroshi Yoshida, Yoshiyuki Taoda, Brian Alvin Johns, Takashi Kawasuji, Daiki Nagamatsu
  • SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES
    Publication number: 20160060274
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound l-l yielding compound II-Il, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Applicants: VIIV HEALTHCARE COMPANY, SHIONOGI & CO., LTD.
    Inventors: Hiroshi YOSHIDA, Yoshiyuki TAODA, Brian Alvin JOHNS, Takashi KAWASUJI, Daiki NAGAMATSU
  • Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
    Patent number: 9242986
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: January 26, 2016
    Assignees: SHIONOGI & CO., LTD., ViiV Healthcare Company
    Inventors: Takashi Kawasuji, Daiki Nagamatsu
  • SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES
    Publication number: 20140243521
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-I1, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicants: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Hiroshi YOSHIDA, Yoshiyuki TAODA, Brian Alvin JOHNS, Takashi KAWASUJI, Daiki NAGAMATSU
  • Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
    Patent number: 8754214
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: June 17, 2014
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Hiroshi Yoshida, Yoshiyuki Taoda, Brian Alvin Johns, Takashi Kawasuji, Daiki Nagamatsu
  • SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES
    Publication number: 20140094605
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Application
    Filed: December 4, 2013
    Publication date: April 3, 2014
    Applicants: ViiV Healthcare Company, Shionogi & Co., Ltd.
    Inventors: Hiroshi YOSHIDA, Yoshiyuki TAODA, Brian Alvin JOHNS, Takashi KAWASUJI, Daiki NAGAMATSU
  • Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
    Patent number: 8624023
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: January 7, 2014
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Hiroshi Yoshida, Yoshiyuki Taoda, Brian Johns, Takashi Kawasuji, Daiki Nagamatsu
  • SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES
    Publication number: 20110282055
    Abstract: A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
    Type: Application
    Filed: December 8, 2009
    Publication date: November 17, 2011
    Inventors: Hiroshi Yoshida, Yoshiyuki Taoda, Brian Johns, Takashi Kawasuji, Daiki Nagamatsu