Patents by Inventor Daina Laniauskas

Daina Laniauskas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for suspension cultures of human pluripotent stem cells
    Patent number: 10377989
    Abstract: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: August 13, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Benjamin Fryer, Daina Laniauskas, Marcia Blackmoore, Haiyun Wang, Kostadinka LiLova, Shelley Nelson, Elizabeth Rosocha
  • Method for making human pluripotent suspension cultures and cells derived therefrom
    Patent number: 10370644
    Abstract: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 6, 2019
    Assignee: Janssen Biotech, Inc.
    Inventors: Benjamin Fryer, Daina Laniauskas, Marcia Blackmoore, Haiyun Wang, Kostadinka Lilova, Shelley Nelson, Elizabeth Rosocha
  • MEDIA SUCTION DEVICES AND METHODS
    Publication number: 20180119082
    Abstract: Devices and methods are provided for removing media from a culture vessel that decreases disruption of the interface between the cellular material and media within the vessel such that aspiration and removal of cells or cell clusters along with the media is minimized. In addition, the media fluid turbulence is decreased so as to minimize the activation or disruption of cells and cell clusters.
    Type: Application
    Filed: December 8, 2017
    Publication date: May 3, 2018
    Applicant: Janssen Biotech, Inc.
    Inventors: Daina Laniauskas, Joseph Hammer
  • MEDIA SUCTION DEVICES AND METHODS
    Publication number: 20180105785
    Abstract: Devices and methods are provided for removing media from a culture vessel that decreases disruption of the interface between the cellular material and media within the vessel such that aspiration and removal of cells or cell clusters along with the media is minimized. In addition, the media fluid turbulence is decreased so as to minimize the activation or disruption of cells and cell clusters.
    Type: Application
    Filed: December 8, 2017
    Publication date: April 19, 2018
    Applicant: Janssen Biotech, Inc.
    Inventors: Daina Laniauskas, Joseph Hammer
  • Media suction devices and methods
    Patent number: 9890353
    Abstract: Devices and methods are provided for removing media from a culture vessel that decreases disruption of the interface between the cellular material and media within the vessel such that aspiration and removal of cells or cell clusters along with the media is minimized. In addition, the media fluid turbulence is decreased so as to minimize the activation or disruption of cells and cell clusters.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 13, 2018
    Assignee: Janssen Biotech, Inc.
    Inventors: Daina Laniauskas, Joseph Hammer
  • Suspension Culturing of Pluripotent Stem Cells
    Publication number: 20160215268
    Abstract: The present invention provides methods of differentiating pluripotent cells into beta cell using suspension clustering. The methods of the invention use control of one or more of pH, cell concentration, and retinoid concentration to generate a nearly homogenous population of PDX1/NKX6.1 co-expressing cells by suppressing precocious NGN3 expression and promoting NKX6.1 expression. Also, the nearly homogenous population of PDX1/NKX6.1 co-expressing cells may be further differentiated in vitro to form a population of pancreatic endocrine cells that co-express PDX1, NKX6.1, insulin and MAFA.
    Type: Application
    Filed: December 9, 2015
    Publication date: July 28, 2016
    Applicant: Janssen Biotech, Inc.
    Inventors: Benjamin Fryer, Daina Laniauskas
  • SUSPENSION AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS FOR DIFFERENTIATION INTO PANCREATIC ENDOCRINE CELLS
    Publication number: 20140295552
    Abstract: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Benjamin FRYER, Daina Laniauskas, Marcia Blackmoore, Haiyun Wang, Kostadinka Lilova, Shelley Nelson, Elizabeth Rosocha
  • Media Suction Devices and Methods
    Publication number: 20140261706
    Abstract: Devices and methods are provided for removing media from a culture vessel that decreases disruption of the interface between the cellular material and media within the vessel such that aspiration and removal of cells or cell clusters along with the media is minimized. In addition, the media fluid turbulence is decreased so as to minimize the activation or disruption of cells and cell clusters.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Daina Laniauskas, Joseph Hammer
  • Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
    Publication number: 20140242693
    Abstract: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.
    Type: Application
    Filed: December 30, 2013
    Publication date: August 28, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Benjamin Fryer, Daina Laniauskas, Marcia Blackmoore, Haiyun Wang, Kostadinka LiLova, Shelly Nelson, Elizabeth Rosocha