Patents by Inventor Dainis Kaldre

Dainis Kaldre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF 1,2,3,5,6,7-HEXAHYDRO-S-INDACENE DERIVATAIVES
    Publication number: 20240400516
    Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
    Type: Application
    Filed: August 13, 2024
    Publication date: December 5, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joséphine Eliette Françoise CINQUALBRE, Stefan HILDBRAND, Dainis KALDRE
  • Process for synthesis of quinazoline compounds
    Patent number: 12071422
    Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: August 27, 2024
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Rene Lebl, Ngiap Kie Lim, Roland Christoph Meier, Ugo Jonathan Orcel, Joerg Sedelmeier, Jeff Shen, Lauren Elizabeth Sirois, Jacob C. Timmerman, Etienne Trachsel, Nicholas Andrew White, Jie Xu, Haiming Zhang, Stephan Bachmann, Thomas Michael Bass, Raphael Bigler, Johannes Adrian Burkhard, Kyle Bradley Pascual Clagg, Francis Gosselin, Chong Han, Dainis Kaldre, Sean M. Kelly, Sebastian Herold, Christian Leitner
  • PROCESS FOR THE MANUFACTURE OF TETRAZOLE DERIVATIVES
    Publication number: 20240002355
    Abstract: The invention relates in particular to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined in the description and in the claims.
    Type: Application
    Filed: May 22, 2023
    Publication date: January 4, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dainis KALDRE, Christian Oliver KAPPE, Christian Steffen MOESSNER, Peter SAGMEISTER, Joerg Mathias SEDELMEIER, Jason Douglas WILLIAMS
  • PROCESS FOR SYNTHESIS OF QUINAZOLINE COMPOUNDS
    Publication number: 20230250074
    Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
    Type: Application
    Filed: February 3, 2023
    Publication date: August 10, 2023
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Rene LEBL, Ngiap Kie LIM, Roland Christoph MEIER, Ugo Jonathan ORCEL, Joerg SEDELMEIER, Jeff SHEN, Lauren Elizabeth SIROIS, Jacob C. TIMMERMAN, Etienne TRACHSEL, Nicholas Andrew WHITE, Jie XU, Haiming ZHANG, Stephan BACHMANN, Thomas Michael BASS, Raphael BIGLER, Johannes Adrian BURKHARD, Kyle Bradley Pascual CLAGG, Francis GOSSELIN, Chong HAN, Dainis KALDRE, Sean M. KELLY, Sebastian HEROLD, Christian LEITNER
  • PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
    Publication number: 20230122620
    Abstract: Provided herein is a process for synthesis of intermediates for ipatasertib related to large scale manufacture of (R)-5-methyl-4-(piperazin-1-yl)-5,6-dihydro-7H-cyclopenta[d]pyrimidin-7-one.
    Type: Application
    Filed: December 12, 2022
    Publication date: April 20, 2023
    Inventors: Dainis Kaldre, Joerg Sedelmeier
  • Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
    Patent number: 9428447
    Abstract: The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 30, 2016
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: James L. Gleason, John H. White, Dainis Kaldre, Joshua Fischer
  • BIS-(ARYL/HETEROARYL)-METHYLENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR TREATING CANCER
    Publication number: 20140315965
    Abstract: The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.
    Type: Application
    Filed: December 20, 2012
    Publication date: October 23, 2014
    Inventors: James L. Gleason, John H. White, Dainis Kaldre, Joshua Fischer