Abstract: An automatic analyzer includes a liquid feed unit including a liquid feed unit and a liquid feed flow passage and feeding a mobile phase, a sample introduction unit introducing a sample to the mobile phase, a separation column separating the sample into plural components, a detector detecting the component, and a control unit. A pressure sensor detecting pressure of the liquid feed flow passage is provided, and the control unit calculates a pressure rise rate of the time immediately after starting liquid feeding of the mobile phase based on the pressure detected by the pressure sensor and a compression pressure variation amount and a pressure average after continuing liquid feeding of the mobile phase for a certain time, and determines completion of equilibration of the separation column.

Abstract: A liquid chromatography (LC) that can supply a mobile phase to a storage bottle and can prevent mixing of air bubbles into a flow path without stopping analysis and liquid feeding. The LC includes a liquid feeding device that feeds out a mobile phase, a sample injection portion that injects a sample into the mobile phase, a column that separates the sample carried by the mobile, and a detection device that detects the sample. The LC further comprises a storage bottle that stores the mobile phase fed by the liquid feeding device, a mobile phase supply bottle that supplies the mobile phase to the storage bottle, a mobile phase supply pump that supplies the mobile phase to the storage bottle, and a control unit that controls an operation of the mobile phase supply pump and determines an amount of the mobile phase to be supplied to the storage bottle.

Abstract: A liquid chromatography analyzer acquires a first output value P1 of a pressure sensor measured by opening a flow passage to the atmosphere or by installing, in a column installation portion, a first column that is not filled with a filler, acquires a second output value P2 of the pressure sensor measured by installing a second column having a known pressure resistance Ps in the column installation portion, and updates a gain of the pressure sensor by using the first output value P1 and the second output value P2. Thus, inspection and adjustment of the pressure sensor can be easily performed without adding a complicated mechanism.

Abstract: Provided is a technology for reducing the capacity of a liquid feeding pump and enabling liquid feeding with little pulsation. A liquid feeding pump according to the present disclosure is provided with: a first plunger pump having a first plunger; a second plunger pump having a second plunger and connected in series with the first plunger pump; a pressure sensor disposed downstream of the second plunger pump; and a control unit that accepts the input of a liquid discharge pressure measured by the pressure sensor and that controls the driving of the first plunger and the driving of the second plunger.

Abstract: The present invention provides a technique that enables liquid feeding with small pulsation by reducing the volume of a liquid feeding pump. Disclosed is a liquid feeding pump comprising: a first plunger pump that has a first plunger; a second plunger pump that has a second plunger and is connected to the first plunger pump in series; a pressure sensor that is disposed on the downstream side of the second plunger pump; and a control unit that accepts an input of the discharge pressure of a liquid measured by the pressure sensor to control driving of the first plunger and driving of the second plunger, wherein when the first plunger pump compresses the liquid, the control unit drives the first plunger at a first speed, and then decreases the speed to a second speed slower than the first speed before the compression is completed, and wherein the control unit discharges the liquid from the second plunger pump by driving the second plunger in parallel with the driving of the first plunger.

Abstract: Tests of channels of a system as a whole can be easily performed without adding a complicated mechanism. A liquid feeding part includes a liquid feeding channel to feed a mobile phase, a drainage channel to release pressure in the liquid feeding channel, an analysis channel that discharges the mobile phase into the sample introduction part, and a channel switching valve that selectively connects the liquid feeding channel to one of the drainage channel and the analysis channel. The channel switching valve is configured to be able to provide a tight stopper state in which the liquid feeding channel is connected to neither the analysis channel nor the drainage channel.

Abstract: A flowpath switch valve is configured for extended service life by spreading the region, of the sliding surfaces of a stator and a rotor, that is subject to wear over the entirety of the sliding surfaces. The stator has fixed stator flowpaths, and the rotor has rotor flowpaths. A flowpath switch valve, depending on the rotor rotation state, realizes connection patterns that include: a first connection pattern wherein a rotor flowpath 241 connects a fixed stator flowpath 31 and a fixed stator flowpath 32; a second connection pattern wherein the rotor flowpath 241 connects the fixed stator flowpath 31 and a fixed stator flowpath 36; a third connection pattern wherein a rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 32; and a fourth connection pattern wherein the rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 36.

Abstract: A liquid chromatograph has a long-life flow passage switching valve with reduced abrasion caused by sliding of flow passage end portions of a stator and flow passage end portions of a rotor seal. The flow passage switching valve includes: a stator; and a rotor seal connected with a rotor configured to rotate and slide on a circumference with respect to the stator. The stator has stator flow passages that open to the rotor seal. The rotor seal has a rotor seal flow passage for coupling two or more of the stator flow passages. A flow passage end portion that is positioned at a tip end in a sliding direction of the rotor seal flow passage is positioned in a direction opposite to the sliding direction of the stator flow passage end portion to be connected to the rotor seal flow passage, at least at the start of sliding.

Abstract: The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.

Abstract: Provided is an inspection method for a liquid feeding device capable of preventing an increase in the number of components, a decrease in throughput, and an increase in a leakage source. The method includes: suctioning a fluid from a fluid tank into a first cylinder by driving a first plunger in a suction direction; driving the first plunger in a discharge direction after suction; stopping the first plunger for a predetermined first time; driving the first plunger in the discharge direction; and estimating a leakage amount in a flow path on an upstream side of a second check valve based on a detection value of a pressure detected by a pressure sensor from start of the driving of the first plunger in the discharge direction to end of the driving of the first plunger in the discharge direction.

Abstract: Implemented is an analysis apparatus column oven equipped with a plurality of columns, which is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes the ferrule, the movable ferrule connector, the pipe, the fastener pull, the fastener fitting, the column cartridge presser, the slide guide, the RFID reader, the fixed wall, the column changer heat insulating member, the fixed bottom plate, the receiver, and the fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

Abstract: An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed.

Abstract: An analysis apparatus column oven equipped with a plurality of columns is capable of efficiently performing heat conduction on column basis, recognizing a column cartridge that holds a column, and being easily exchanged on column basis. The column change mechanism includes a ferrule, a movable ferrule connector, a pipe, a fastener pull, a fastener fitting, a column cartridge presser, a slide guide, an RFID reader, a fixed wall, a column changer heat insulating member, a fixed bottom plate, a receiver, and a fixed fitting. A plurality of column cartridges can be installed in the heat block, and are in contact with the column heat block to control the temperature in the column cartridges. The column cartridge is fixed between left and right column change mechanisms, and when the fixed column cartridge is opened, the column change mechanism on the left side is moved leftward and opened.

Abstract: To provide a liquid chromatograph and a liquid delivery method capable of more easily and reliably removing bubbles mixed during mobile phase installation or replacement operation.

Abstract: A liquid chromatography (LC) that can supply a mobile phase to a storage bottle and can prevent mixing of air bubbles into a flow path without stopping analysis and liquid feeding. The LC includes a liquid feeding device that feeds out a mobile phase, a sample injection portion that injects a sample into the mobile phase, a column that separates the sample carried by the mobile, and a detection device that detects the sample. The LC further comprises a storage bottle that stores the mobile phase fed by the liquid feeding device, a mobile phase supply bottle that supplies the mobile phase to the storage bottle, a mobile phase supply pump that supplies the mobile phase to the storage bottle, and a control unit that controls an operation of the mobile phase supply pump and determines an amount of the mobile phase to be supplied to the storage bottle.

Abstract: An automatic analyzer includes a liquid feed unit including a liquid feed unit and a liquid feed flow passage and feeding a mobile phase, a sample introduction unit introducing a sample to the mobile phase, a separation column separating the sample into plural components, a detector detecting the component, and a control unit. A pressure sensor detecting pressure of the liquid feed flow passage is provided, and the control unit calculates a pressure rise rate of the time immediately after starting liquid feeding of the mobile phase based on the pressure detected by the pressure sensor and a compression pressure variation amount and a pressure average after continuing liquid feeding of the mobile phase for a certain time, and determines completion of equilibration of the separation column.

Abstract: A liquid chromatography analyzer acquires a first output value P1 of a pressure sensor measured by opening a flow passage to the atmosphere or by installing, in a column installation portion, a first column that is not filled with a filler, acquires a second output value P2 of the pressure sensor measured by installing a second column having a known pressure resistance Ps in the column installation portion, and updates a gain of the pressure sensor by using the first output value P1 and the second output value P2. Thus, inspection and adjustment of the pressure sensor can be easily performed without adding a complicated mechanism.

Abstract: The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409).

Abstract: The analysis apparatus includes a standby section which is provided between a dispensing operation of an analysis item B? prior to an analysis item C and the sample analysis channel introduction. The sample analysis channel introduction is arranged prior to a data collection section of an analysis item A. The operation is started earlier but after a sample dispensing operation section of the analysis item A. A sample dispensing operation section of the analysis item C can be started earlier and the analysis time of the analysis item C can be moved to immediately after a sample analysis operation section of the analysis item B?. The analysis item A in a second cycle can be started earlier by the early start time of the analysis item C in a first cycle. A total processing time Tc can be shorter than a total processing time Tb.

Abstract: A liquid feed pump which increases the liquid flow velocity in a stagnation area in the pressure chamber of a plunger pump, thereby improving the liquid replacement speed in the plunger pump. When the liquid in the liquid feed pump is replaced, a first plunger slides back and forth in the space between a lower limit point and an upper limit point, and the second plunger stops at least temporarily at a position near to the upper limit point or slides back and forth for a shorter distance than when the liquid feed pump usually feeds the liquid.