Patents by Inventor Daisuke Kiga

Daisuke Kiga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing functional non-naturally occurring proteins, and method for site-specific modification and immobilization of the proteins
    Patent number: 8227209
    Abstract: There is provided a process for industrial production of non-naturally occurring proteins composed of less than 20 amino acids, wherein the proteins retain their original functions while being capable of site-specific modification or immobilization, or having new functions not found in nature in addition to the original functions of the proteins. Specifically there are provided a process for producing a functional non-naturally occurring protein having a specific amino acid type(s) replaced with a natural amino acid(s) other than the amino acid type(s).
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: July 24, 2012
    Assignees: Tokyo Institute of Technology, Celagix Research Ltd.
    Inventors: Daisuke Kiga, Masahiko Uchiyama
  • Process for producing functional non-naturally occurring proteins, and method for site-specific modification and immobilization of the proteins
    Publication number: 20090011459
    Abstract: There is provided a process for industrial production of non-naturally occurring proteins composed of less than 20 amino acids, wherein the proteins retain their original functions while being capable of site-specific modification or immobilization, or having new functions not found in nature in addition to the original functions of the proteins.
    Type: Application
    Filed: March 3, 2008
    Publication date: January 8, 2009
    Inventors: Daisuke Kiga, Masahiko Uchiyama
  • Tyrosyl-tRNA synthetase variants
    Patent number: 7393670
    Abstract: Tyrosyl-tRNA synthetases having a modified amino acid sequence whereby unnatural amino acids can be more efficiently incorporated than original natural amino acids. More specifically, tyrosyl-tRNA synthetases having been modified at the amino acid(s) at the 37- and/or 195-positions. A method of modifying tyrosyl-tRNA synthetase characterized in that the position of an amino acid to be modified is determined based on the 3-D structure of a tyrosyl-AMP and of tyrosyl synthetase complex and an amino acid to which this enzyme binds.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: July 1, 2008
    Assignee: Japan Science and Technology Agency
    Inventors: Daisuke Kiga, Kensaku Sakamoto, Ichiro Hirao, Shigeyuki Yokoyama
  • Tyrosyl-trna syntiiase variants
    Publication number: 20050084856
    Abstract: Tyrosyl-tRNA synthetases having a modified amino acid sequence whereby unnatural amino acids can be more efficiently incorporated than original natural amino acids. More specifically, tyrosyl-tRNA synthetases having been modified at the amino acid(s) at the 37- and/or 195-positions. A method of modifying tyrosyl-tRNA synthetase characterized in that the position of an amino acid to be modified is determined based on the 3-D structure of a tyrosyl-AMP and of tyrosyl synthetase complex and an amino acid to which this enzyme binds.
    Type: Application
    Filed: January 11, 2002
    Publication date: April 21, 2005
    Inventors: Daisuke Kiga, Kensaku Sakamoto, Ichiro Hirao, Shigeyuki Yokoyama