Abstract: In the method for producing an optically active 2,3-bisphosphinopyrazine derivative of the present invention, an optically active 2,3-bisphosphinopyrazine derivative represented by the following formula (3) is produced by the step of: preparing solution A containing 2,3-dihalogenopyrazine represented by the following formula (1) and a carboxylic acid amide coordinating solvent, lithiating an optically active R- or S-isomer of a hydrogen-phosphine borane compound represented by the following formula (2) to give a lithiated phosphine borane compound; adding solution B containing the lithiated phosphine borane compound to the solution A to perform an aromatic nucleophilic substitution reaction; and then performing a deboranation reaction. (For symbols in the formulas, see the description.

Abstract: In the method for producing an optically active 2,3-bisphosphinopyrazine derivative of the present invention, an optically active 2,3-bisphosphinopyrazine derivative represented by the following formula (3) is produced by the step of: preparing solution A containing 2,3-dihalogenopyrazine represented by the following formula (1) and a carboxylic acid amide coordinating solvent, lithiating an optically active R- or S-isomer of a hydrogen-phosphine borane compound represented by the following formula (2) to give a lithiated phosphine borane compound; adding solution B containing the lithiated phosphine borane compound to the solution A to perform an aromatic nucleophilic substitution reaction; and then performing a deboranation reaction. (For symbols in the formulas, see the description.

Abstract: An object of the present invention is to provide an optically active phosphine-borane compound and a method for producing the same which are useful for the production of an optically active phosphine ligand and allow easy production of any antipode. There is provided a phosphine-borane compound represented by the following general formula (P-1). There is also provided a method for producing the phosphine-borane compound, the method comprising subjecting a hydrogen-phosphine-borane compound represented by the following general formula (P-2) to a coupling reaction with an optically active isocyanate compound represented by the following general formula (3).

Abstract: A process for producing a biarylphosphine compound is disclosed. The process has a step of subjecting a biarylsulfonate compound to coupling reaction with a hydrogen-phosphine compound in the presence of a catalyst and an organic strong base to obtain a biarylphosphine compound. As the catalyst, preferably used is a nickel compound or a palladium compound. As the organic strong base, preferably used is 1,8-diazabicyclo[5.4.0]undecene-7 (DBU).

Abstract: An object of the present invention is to provide an optically active phosphine-borane compound and a method for producing the same which are useful for the production of an optically active phosphine ligand and allow easy production of any antipode. There is provided a phosphine-borane compound represented by the following general formula (P-1). There is also provided a method for producing the phosphine-borane compound, the method comprising subjecting a hydrogen-phosphine-borane compound represented by the following general formula (P-2) to a coupling reaction with an optically active isocyanate compound represented by the following general formula (3).

Abstract: A process for producing a biarylphosphine compound is disclosed. The process has a step of subjecting a biarylsulfonate compound to coupling reaction with a hydrogen-phosphine compound in the presence of a catalyst and an organic strong base to obtain a biarylphosphine compound. As the catalyst, preferably used is a nickel compound or a palladium compound. As the organic strong base, preferably used is 1,8-diazabicyclo[5.4.0]undecene-7 (DBU).