Patents by Inventor Daisuke MOTOOKA

Daisuke MOTOOKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DETECTING CONJUNCTIVAL DISEASE USING OCULAR SURFACE TISSUE, AND AGING BIOMARKER
    Publication number: 20250305071
    Abstract: A method for detecting conjunctival diseases such as conjunctival MALT lymphoma, and an aging biomarker that serves as an indicator of the aging state of a subject are provided. The method for detecting conjunctival diseases comprises a step of comparing a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a healthy person with a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a subject to determine that the ocular surface tissue specimen of the subject has an indication of the conjunctival diseases. The aging biomarker comprises bacterial species which belongs to the Corynebacteriaceae family or the Propionibacteriales family in an ocular surface tissue.
    Type: Application
    Filed: June 16, 2025
    Publication date: October 2, 2025
    Inventors: Kohji NISHIDA, Noriyasu HASHIDA, Tetsuya IIDA, Shota NAKAMURA, Daisuke MOTOOKA, Kazunobu ASAO, Satoru ANDO
  • Method of detecting conjunctival disease using ocular surface tissue, and aging biomarker
    Patent number: 12365950
    Abstract: A method for detecting conjunctival diseases such as conjunctival MALT lymphoma, and an aging biomarker that serves as an indicator of the aging state of a subject are provided. The method for detecting conjunctival diseases comprises a step of comparing a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a healthy person with a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a subject to determine that the ocular surface tissue specimen of the subject has an indication of the conjunctival diseases. The aging biomarker a comprises bacterial species which belongs to the Corynebacteriaceae family or the Propionibacteriales family in an ocular surface tissue.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 22, 2025
    Assignees: Osaka University, Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kohji Nishida, Noriyasu Hashida, Tetsuya Iida, Shota Nakamura, Daisuke Motooka, Kazunobu Asao, Satoru Ando
  • METHOD OF DETECTING CONJUNCTIVAL DISEASE USING OCULAR SURFACE TISSUE, AND AGING BIOMARKER
    Publication number: 20210214775
    Abstract: It aims to construct a technology in which the onset or progression of an aging state or a specific disease can be evaluated in an objective and highly reproducible manner, and in particular, to provide a method of detecting conjunctival diseases such as conjunctival MALT lymphoma, and to provide an aging biomarker that serves as an indicator of the aging state.
    Type: Application
    Filed: June 28, 2019
    Publication date: July 15, 2021
    Inventors: Kohji NISHIDA, Noriyasu HASHIDA, Tetsuya IIDA, Shota NAKAMURA, Daisuke MOTOOKA, Kazunobu ASAO, Satoru ANDO
  • Peptide inhibiting colonization by pathogenic bacteria, and colonization inhibitor including same
    Patent number: 10829522
    Abstract: A peptide capable of preventing pathogenic bacteria from colonizing in digestive organs comprises a first domain having an amino acid sequence capable of binding to a minor pilin of IVb fimbriae, and a second domain having an amino acid sequence capable of multimerization, the second domain connect to the first domain via a linker sequence.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: November 10, 2020
    Assignees: OSAKA UNIVERSITY, BIKENBIOMICS CO., LTD.
    Inventors: Shota Nakamura, Kazuki Kawahara, Hiroya Oki, Takuya Yoshida, Tadayasu Ohkubo, Yuji Kobayashi, Takahiro Maruno, Daisuke Motooka, Shigeaki Matsuda, Toshio Kodama, Tetsuya Iida, Yasumitsu Tsujino, Shunsuke Fukakusa
  • PEPTIDE INHIBITING COLONIZATION BY PATHOGENIC BACTERIA, AND COLONIZATION INHIBITOR INCLUDING SAME
    Publication number: 20190284246
    Abstract: A peptide capable of preventing pathogenic bacteria from colonizing in digestive organs comprises a first domain having an amino acid sequence capable of binding to a minor pilin of IVb fimbriae, and a second domain having an amino acid sequence capable of multimerization, the second domain connect to the first domain via a linker sequence.
    Type: Application
    Filed: April 25, 2017
    Publication date: September 19, 2019
    Applicants: OSAKA UNIVERSITY, BIKENBIOMICS CO., LTD
    Inventors: Shota NAKAMURA, Kazuki KAWAHARA, Hiroya OKI, Takuya YOSHIDA, Tadayasu OHKUBO, Yuji KOBAYASHI, Takahiro MARUNO, Daisuke MOTOOKA, Shigeaki MATSUDA, Toshio KODAMA, Tetsuya IIDA, Yasumitsu TSUJINO, Shunsuke FUKAKUSA