Abstract: A microphone assembly comprises a circuit board, a microphone element connected to the circuit board, an external connection interface connected to the circuit board, and hot melt that is formed to cover the circuit board, the microphone element, and the external connection interface and has a hole formed to expose a part of the back side of the circuit board or the sound receiving part of the microphone element.

Abstract: A cutting device capable of efficiently cutting an object with a simple configuration includes a grasp unit including a first grasper and a second grasper movable in an opening and closing directions to grasp the object, a cutting unit disposed side by side with the first and second graspers and moved in a cutting direction along the opening and closing directions to cut the object, and a position setter setting a cutting start position and a cutting end position based on respective positions of the first and second graspers that are grasping the object, respectively.

Abstract: An antigen-loaded nanogel is formed by loading or encapsulating one or more long peptide antigens or one or more protein antigens in a hydrophobized polysaccharide. The long peptide antigen(s) or protein antigen(s) contains (or each contain) one or more CD8+ cytotoxic T cell recognition epitopes and/or one or more CD4+ helper T cell recognition epitopes, which is/are derived from the antigen. The antigen-loaded nanogel is administered at least one day prior to administration of antigen-specific T cells to improve the efficacy of a T cell infusion therapy against an immune checkpoint inhibitor-resistant tumor. The hydrophobized polysaccharide may be pullulan having cholesteryl groups bound thereto. An immune-enhancing agent also may be administered in or with the antigen-loaded nanogel.

Abstract: A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor.

Abstract: Provided is a method for using a STAT3 inhibitor which exhibits an excellent antitumor effect. An antitumor agent comprises a quinoline carboxamide derivative of formula (I) below or a salt thereof as an active ingredient, and is administered in combination with an immune checkpoint inhibitor. The antitumor agent is administered before the administration of the immune checkpoint inhibitor.

Abstract: A long-chain peptide antigen includes a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains four to ten consecutive tyrosines, threonines, alanines, histidines, glutamines, or asparagines. The killer T-cell recognition epitopes form complexes with MHC class I molecules and are recognized by CD8+ killer T-cells when the complexes are presented on the surfaces of antigen-presenting cells. The helper T-cell recognition epitopes form complexes with MHC class II molecules and are recognized by CD4+ helper T-cells when the complexes are presented on the surfaces of antigen-presenting cells. The peptide is cleaved within the first interepitope sequence upon uptake of the peptide into antigen-presenting cells. The long-chain peptide antigen may be administered to a patient together with a hydrophobized polysaccharide, such as cholesterol-modified pullulan, and/or an adjuvant, such as CpG oligo DNA.

Abstract: To provide an agent for overcoming immunosuppression which can overcome immunosuppression by regulatory T cells. An agent for overcoming immunosuppression and an inhibitor of FOXP3 function containing an anthracycline antibiotic as an active ingredient.

Abstract: A long-chain peptide antigen includes a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains four to ten consecutive tyrosines. The long-chain peptide antigen may be administered to a patient together with a hydrophobized polysaccharide, such as cholesterol-modified pullulan, and/or an adjuvant, such as CpG oligo DNA.

Abstract: To reduce effects of noise and improve detection accuracy, a sensor device includes: a detection electrode opposing an external electrode to which a predetermined voltage is applied, and configured to generate a voltage corresponding to a change in electrostatic capacitance; and a capacitive amplifier circuit having a first capacitor and a second capacitor connected in series to each other, and configured to detect the voltage generated in the detection electrode, and output a detection signal obtained by amplifying the voltage generated in the detection electrode based on a capacitance ratio between the first capacitor and the second capacitor.

Abstract: A cutting device capable of efficiently cutting an object with a simple configuration includes a grasp unit including a first grasper and a second grasper movable in an opening and closing directions to grasp the object, a cutting unit disposed side by side with the first and second graspers and moved in a cutting direction along the opening and closing directions to cut the object, and a position setter setting a cutting start position and a cutting end position based on respective positions of the first and second graspers that are grasping the object, respectively.

Abstract: A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor.

Abstract: An output driver circuit provides an overcurrent protection function by a simple circuit configuration. The output driver circuit has a constant-current circuit, a constant-current mirror MOS transistor, and a selector circuit. The constant-current mirror MOS transistor and the output MOS transistor constitute a current mirror circuit. The gate of the output MOS transistor is controlled by a voltage based on a constant current generated by the constant-current mirror MOS transistor, thereby limiting the current flowing between the source and the drain of the output MOS transistor.

Abstract: To reduce effects of noise and improve detection accuracy, a sensor device includes: a detection electrode opposing an external electrode to which a predetermined voltage is applied, and configured to generate a voltage corresponding to a change in electrostatic capacitance; and a capacitive amplifier circuit having a first capacitor and a second capacitor connected in series to each other, and configured to detect the voltage generated in the detection electrode, and output a detection signal obtained by amplifying the voltage generated in the detection electrode based on a capacitance ratio between the first capacitor and the second capacitor.

Abstract: An antigen-loaded nanogel is formed by loading or encapsulating one or more long peptide antigens or one or more protein antigens in a hydrophobized polysaccharide. The long peptide antigen(s) or protein antigen(s) contains (or each contain) one or more CD8+ cytotoxic T cell recognition epitopes and/or one or more CD4+ helper T cell recognition epitopes, which is/are derived from the antigen. The antigen-loaded nanogel may be administered prior to administration of antigen-specific T cells to improve the efficacy of a T cell infusion therapy against an immune checkpoint inhibitor-resistant tumor. The hydrophobized polysaccharide may be pullulan having cholesteryl groups bound thereto. An immune-enhancing agent also may be administered in or with the antigen-loaded nanogel.

Abstract: To provide an agent for overcoming immunosuppression which can overcome immunosuppression by regulatory T cells. An agent for overcoming immunosuppression and an inhibitor of FOXP3 function containing an anthracycline antibiotic as an active ingredient.

Abstract: A long-chain peptide antigen includes a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains four to ten consecutive tyrosines. The long-chain peptide antigen may be administered to a patient together with a hydrophobized polysaccharide, such as cholesterol-modified pullulan, and/or an adjuvant, such as CpG oligo DNA.

Abstract: Provided is a working machine including a device to be maintained and a winch disposed thereover and enabling a maintenance operation. The working machine includes a base machine, at least one device to be maintained installed at the base machine, and a winch which is driven to wind an operation rope. The winch is attached to the base machine to be pivotable, about a winch support shaft, between a use position at which the winch is used while closing at least a part of a maintenance space over the device to be maintained and a maintenance position at which the winch opens the maintenance space upward to enable the maintenance operation to be performed.

Abstract: To provide a magnetic sensor circuit that outputs a desired detection pulse while preventing an erroneous detection/erroneous release pulse output when a fluctuation in a power supply voltage occurs within an operating power supply voltage range. A magnetic sensor circuit is configured to include a detection circuit that detects a fluctuation in a power supply voltage or an internal power supply voltage and so as not to latch a determination output of a comparator by a latch circuit that, on the basis of a power supply fluctuation detection signal output from the detection circuit, holds the logic of a control clock signal output from an oscillation circuit for a prescribed period of time and determines the output logic of an output terminal.

Abstract: A vaccine contains a long-chain peptide antigen having a plurality of epitopes. An interepitope sequence located between two of the plurality of epitopes contains two to ten consecutive tyrosines, two to ten consecutive threonines, two to ten consecutive alanines, two to ten consecutive histidines, two to ten consecutive glutamines or two to ten consecutive asparagines. The vaccine may be an anticancer vaccine, an antibacterial vaccine or an antiviral vaccine. The vaccine may be a peptide vaccine, a DNA vaccine, an mRNA vaccine or a dendritic cell vaccine.

Abstract: To provide a small-area photoelectric conversion device without impairing a resolution switching function, signals for controlling output order control switches provided so as to correspond to photoelectric conversion elements are selected by an output order control circuit and a shift register. In this manner, the number of flip-flops forming a shift register is reduced.