Abstract: A brake device includes: a brake pedal including a pedal and a lever that rotates about a rotation axis when the pedal is operated; a housing that rotatably supports the lever; a reaction force generator that generates a reaction force to the lever in accordance with a stroke amount of the brake pedal by receiving a force from the lever when the brake pedal is operated; a deformation member including a deformation portion that is deformed by a force received from the lever when the brake pedal is operated in a state where the reaction force generated by the reaction force generator is generated; and a stroke sensor that outputs a signal corresponding to the stroke amount and outputs a value indicating that operation of the brake pedal is abnormal and instructing execution of control for stopping a vehicle when the deformation portion is deformed.

Abstract: A brake device for a vehicle includes: a brake pedal having a pedal portion and a lever portion that rotates about a rotation axis when the pedal portion is operated; a housing that rotatably supports the lever portion; and a plate member configured to generate a reaction force with respect to the lever portion in response to a stroke amount of the brake pedal. The plate member has a longitudinal surface defined by a side extending in a longitudinal direction of the plate member and a side extending in a width direction of the plate member. The longitudinal surface is arranged so as to face the lever portion. When the pedal portion is operated, the plate member is bent to generate the reaction force.

Abstract: A brake device includes: a brake pedal including a pedal and a lever that rotates about a rotation axis when the pedal is operated; a housing that rotatably supports the lever; a reaction force generator that generates a reaction force to the lever in accordance with a stroke amount of the brake pedal by receiving a force from the lever when the brake pedal is operated; a deformation member including a deformation portion that is deformed by a force received from the lever when the brake pedal is operated in a state where the reaction force generated by the reaction force generator is generated; and a stroke sensor that outputs a signal corresponding to the stroke amount and outputs a value indicating that operation of the brake pedal is abnormal and instructing execution of control for stopping a vehicle when the deformation portion is deformed.

Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.

Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.

Abstract: The present invention provides a method for screening a cytostatic agent characterized by determining an effect of inhibiting intracellular signaling mediated by a remaining fragment of a cell membrane-anchored growth factor, and the cytostatic agent. In growth factors of the EGF family, the physiological significance of the remaining fragment is clarified, and a method for controlling its action is searched, and thus a novel pharmaceutical can be provided.

Abstract: The present invention provides a method for screening a cytostatic agent characterized by determining an effect of inhibiting intracellular signaling mediated by a remaining fragment of a cell membrane-anchored growth factor, and the cytostatic agent. In growth factors of the EGF family, the physiological significance of the remaining fragment is clarified, and a method for controlling its action is searched, and thus a novel pharmaceutical can be provided.