Abstract: A thermal barrier coating film includes a bond coat layer that is a metallic bond layer formed on a base material; a topcoat layer that is a ceramic-containing layer formed on the bond coat layer; and at least one of a protective layer and a protective substance. The protective layer is formed on the topcoat layer and mainly contains SrSO4. The protective substance is provided in a plurality of void spaces included in the topcoat layer and mainly contains SrSO4.

Abstract: A thermal barrier coating includes a bond coat layer deposited on a substrate, and a ceramic layer deposited on the bond coat layer. The ceramic layer includes a first layer having a porosity of 10% or more and 15% or less, and a second layer having a porosity of 0.5% or more and 9.0% or less and deposited on the first layer.

Abstract: A thermal barrier coating includes a highly porous layer and a dense layer. The highly porous layer is formed on a heat-resistant base, is made of ceramic, has pores, has a layer thickness of equal to or larger than 0.3 mm and equal to or smaller than 1.0 mm, and has a pore ratio of equal to or higher than 1 vol % and equal to or lower than 30 vol %. The dense layer is formed on the highly porous layer, is made of ceramic, has a pore ratio of equal to or lower than 0.9 vol % that is equal to or lower than the pore ratio of the highly porous layer, and has a layer thickness of equal to or smaller than 0.05 mm.

Abstract: An ignition device ignites a mixture of air and fuel gas by plasma to generate an initial flame. The ignition device includes a spark plug having an inner conductor, a cylindrical outer conductor that holds the inner conductor inside, and a dielectric provided between the inner conductor and the outer conductor, and the spark plug configured to emit an electromagnetic wave to a plasma formation space between the inner conductor and the outer conductor to generate a plasma. The ignition device includes an electromagnetic wave power supply that generates the electromagnetic wave by inputting the electromagnetic wave power Ps to the spark plug and a power supply control unit that controls the electromagnetic wave power supply. The electromagnetic wave power supply is configured to generate high frequency power at a number of different frequencies.

Abstract: The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

Abstract: An ignition device ignites a mixture of air and fuel gas by plasma to generate an initial flame. The ignition device includes a spark plug having an inner conductor, a cylindrical outer conductor that holds the inner conductor inside, and a dielectric provided between the inner conductor and the outer conductor, and the spark plug configured to emit an electromagnetic wave to a plasma formation space between the inner conductor and the outer conductor to generate a plasma. The ignition device includes an electromagnetic wave power supply that generates the electromagnetic wave by inputting the electromagnetic wave power Ps to the spark plug and a power supply control unit that controls the electromagnetic wave power supply. The electromagnetic wave power supply is configured to generate high frequency power at a number of different frequencies.

Abstract: A ceramic coating includes: a ceramic layer; a molten-and-solidified layer formed on a surface of the ceramic layer; and a packed layer including ceramic packed in a crack which extends in a thickness direction of the molten-and-solidified layer.

Abstract: A method of repairing a ceramic coating according to an embodiment includes forming a second ceramic layer by thermally spraying ceramic spray particles to a repair section of the ceramic coating in which a first ceramic layer is formed, and melting a part of an interface, on a surface side of the ceramic coating, between the first ceramic layer and the second ceramic layer by heating the part.

Abstract: A thermal barrier coating film includes a bond coat layer that is a metallic bond layer formed on a base material; a topcoat layer that is a ceramic-containing layer formed on the bond coat layer; and at least one of a protective layer and a protective substance. The protective layer is formed on the topcoat layer and mainly containing SrSO4. The protective substance is provided in the interior of a plurality of void spaces included in the topcoat layer and mainly contains SrSO4.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An automotive vehicle on which a motor for traveling, a battery configured to supply electric power to the motor, and a charging system configured to charge the battery, are installed. The automotive vehicle includes an abnormality informing unit configured to immediately inform occurrence of an abnormality regarding the charging system when the abnormality is detected, on a condition that the abnormality is a first abnormality that affects traveling, and inform occurrence of an abnormality when a next trip is started, on a condition that the abnormality is a second abnormality that does not affect traveling.

Abstract: A method for producing an antibody-drug conjugate composition, comprising: (i) a step of reacting an antibody with a reducing agent in a buffer to reduce interchain disulfides, and (ii) a step of reacting drug linker intermediates with the antibody having thiol groups obtained in the step (i), wherein the reaction temperature in the step (i) is ?10° C. to 10° C., and the average number of bound drugs in the produced antibody-drug conjugate composition is 3.5 to 4.5, and the content of antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, in the produced antibody-drug conjugate composition is 50% or more; and an antibody-drug conjugate composition, wherein the content of antibody-drug conjugates wherein the average number of bound drugs is 3.5 to 4.5, and the content of antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, is 50% or more.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A vehicle comprises a motor configured to output a power for driving; a power storage device configured to supply electric power to the motor; a main relay provided between the motor and the power storage device; a power receiving connector configured to be connectable with a power feed connector of an external charger; and a charging relay connected with the power receiving connector and connected with the power storage device via the main relay. This vehicle further comprises a control device configured to determine whether electric power from the external charger is supplied to the power receiving connector during charging of the power storage device with the electric power from the external charger in closed positions of the main relay and the charging relay and to open the main relay when it is determined that the electric power from the external charger is not supplied to the power receiving connector.

Abstract: An object is to avoid the situation in which the power cannot be turned off. A control system is provided in which the first and second control units are connected. At least one of the first and second control units include: a stop control section for, if a condition for ending a predetermined operation mode is satisfied in that operation mode, performing stop control for having the control system in a low-power-consumption state while communicating with the other control unit; and a mode control section for having a mode undefined state in which the operation mode is instable at restoration from a reset state and for allowing, if a predetermined transition condition for allowing transition into the operation mode is satisfied in the mode undefined state, transition into the operation mode whose transition condition has been satisfied.

Abstract: An automotive vehicle on which a motor for traveling, a battery configured to supply electric power to the motor, and a charging system configured to charge the battery, are installed. The automotive vehicle includes an abnormality informing unit configured to immediately inform occurrence of an abnormality regarding the charging system when the abnormality is detected, on a condition that the abnormality is a first abnormality that affects traveling, and inform occurrence of an abnormality when a next trip is started, on a condition that the abnormality is a second abnormality that does not affect traveling.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An object is to avoid the situation in which the power cannot be turned off. A control system is provided in which the first and second control units are connected. At least one of the first and second control units include: a stop control section for, if a condition for ending a predetermined operation mode is satisfied in that operation mode, performing stop control for having the control system in a low-power-consumption state while communicating with the other control unit; and a mode control section for having a mode undefined state in which the operation mode is instable at restoration from a reset state and for allowing, if a predetermined transition condition for allowing transition into the operation mode is satisfied in the mode undefined state, transition into the operation mode whose transition condition has been satisfied.