Patents by Inventor Daisuke Shinmyo
Daisuke Shinmyo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9453000Abstract: Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by A?, wherein Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.Type: GrantFiled: August 28, 2008Date of Patent: September 27, 2016Assignee: EISAI R&D MANAGEMENT CO., LTD.Inventors: Teiji Kimura, Noritaka Kitazawa, Toshihiko Kaneko, Nobuaki Sato, Koki Kawano, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Yu Yoshida, Toshiyuki Uemura, Takashi Doko, Daisuke Shinmyo, Daiju Hasegawa, Takehiko Miyagawa, Hiroaki Hagiwara
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Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
Patent number: 8754100Abstract: A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by A?.Type: GrantFiled: February 24, 2010Date of Patent: June 17, 2014Assignee: EISAI R&D Management Co., Ltd.Inventors: Noritaka Kitazawa, Daisuke Shinmyo, Koichi Ito, Nobuaki Sato, Daiju Hasegawa, Toshiyuki Uemura, Toru Watanabe -
Nitrogen-Containing Fused Heterocyclic Compounds and Their use as Beta Amyloid Production Inhibitors
Publication number: 20120053171Abstract: A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by A?.Type: ApplicationFiled: February 24, 2010Publication date: March 1, 2012Inventors: Noritaka Kitazawa, Daisuke Shinmyo, Koichio Ito, Nobuaki Sato, Daiju Hasegawa, Toshiyuki Uemura, Toru Watanabe -
Patent number: 7935815Abstract: A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by A?.Type: GrantFiled: August 28, 2008Date of Patent: May 3, 2011Assignee: Eisai R&D Management Co., Ltd.Inventors: Teiji Kimura, Noritaka Kitazawa, Toshihiko Kaneko, Nobuaki Sato, Koki Kawano, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Yu Yoshida, Toshiyuki Uemura, Takashi Doko, Daisuke Shinmyo, Daiju Hasegawa, Takehiko Miyagawa, Hiroaki Hagiwara
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Publication number: 20110065696Abstract: A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by A?.Type: ApplicationFiled: November 19, 2010Publication date: March 17, 2011Inventors: Teiji KIMURA, Noritaka Kitazawa, Toshihiko Kaneko, Nobuaki Sato, Koki Kawano, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Yu Yoshida, Toshiyuki Uemura, Takashi Doko, Daisuke Shinmyo, Daiju Hasegawa, Takehiko Miyagawa, Hiroaki Hagiwara
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Publication number: 20110009619Abstract: Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by A?, wherein Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.Type: ApplicationFiled: August 28, 2008Publication date: January 13, 2011Applicant: Eisai R&D Management Co., Ltd.Inventors: Teiji Kimura, Noritaka Kitazawa, Toshihiko Kaneko, Nobuaki Sato, Koki Kawano, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Yu Yoshida, Toshiyuki Uemura, Takashi Doko, Daisuke Shinmyo, Daiju Hasegawa, Takehiko Miyagawa, Hiroaki Hagiwara
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Publication number: 20090062529Abstract: A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by A?.Type: ApplicationFiled: August 28, 2008Publication date: March 5, 2009Inventors: Teiji KIMURA, Noritaka Kitazawa, Toshihiko Kaneko, Nobuaki Sato, Koki Kawano, Koichi Ito, Mamoru Takaishi, Takeo Sasaki, Yu Yoshida, Toshiyuki Uemura, Takashi Doko, Daisuke Shinmyo, Daiju Hasegawa, Takehiko Miyagawa, Hiroaki Hagiwara
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Publication number: 20080119518Abstract: The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.Type: ApplicationFiled: February 2, 2006Publication date: May 22, 2008Inventors: Yuichi Suzuki, Koichi Ito, Atsushi Sasaki, Koshi Ueno, Daisuke Shinmyo, Miyuki Sakai, Hiroki Ishihara, Atsuhiko Kubota
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Patent number: 7112593Abstract: An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom.Type: GrantFiled: March 27, 2002Date of Patent: September 26, 2006Assignee: Eisai Co., Ltd.Inventors: Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Seiji Yoshikawa, Daisuke Shinmyo, Nobuhisa Watanabe, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito
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Publication number: 20060084658Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.Type: ApplicationFiled: September 20, 2005Publication date: April 20, 2006Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Slinji Hatakeyama
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Patent number: 6906072Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 on hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.Type: GrantFiled: January 18, 2001Date of Patent: June 14, 2005Assignee: Eisai Co., Ltd.Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Shinji Hatakeyama
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Publication number: 20040220193Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.Type: ApplicationFiled: May 28, 2004Publication date: November 4, 2004Applicant: Eisai Co., Ltd.Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Shinji Hatakeyama
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Publication number: 20040072830Abstract: The present invention provides an excellent squalene synthase inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them.Type: ApplicationFiled: July 30, 2003Publication date: April 15, 2004Inventors: Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Seiji Yoshikawa, Daisuke Shinmyo, Nobuhisa Watanabe, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito
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Patent number: 6599917Abstract: The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them.Type: GrantFiled: March 19, 2002Date of Patent: July 29, 2003Assignee: Eisai Co., Ltd.Inventors: Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Kazuki Miyazaki, Daisuke Shinmyo, Hiroyuki Sugumi, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito