Patents by Inventor Daisuke Sugimori

Daisuke Sugimori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Measurement of Lp-PLAactivity
    Patent number: 10900063
    Abstract: An object of the present invention is to provide a highly versatile, simple and safe method for measuring Lp-PLA2 activity. Another object of the present invention is to provide an accurate and highly sensitive method for measuring Lp-PLA2 activity. Provided is a method for measuring lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in a sample containing Lp-PLA2, the method comprising the following steps (A) to (C): (A) converting PAFs into lyso-PAFs by reacting the PAFs with the Lp-PLA2 in the sample; (B) hydrolyzing the lyso-PAFs produced in the step (A) with an enzyme (lyso-PAF-PLD) to obtain hydrolysate; and (C) measuring Lp-PLA2 activity in the sample by utilizing a quantitative change attributable to the hydrolysate obtained in step (B) as an indicator.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: January 26, 2021
    Assignee: ASAHI KASEI PHARMA CORPORATION
    Inventors: Shinichi Sakasegawa, Saki Yamaura, Daisuke Sugimori
  • MEASUREMENT OF LP-PLA2 ACTIVITY
    Publication number: 20200002744
    Abstract: An object of the present invention is to provide a highly versatile, simple and safe method for measuring Lp-PLA2 activity. Another object of the present invention is to provide an accurate and highly sensitive method for measuring Lp-PLA2 activity. Provided is a method for measuring lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in a sample containing Lp-PLA2, the method comprising the following steps (A) to (C): (A) converting PAFs into lyso-PAFs by reacting the PAFs with the Lp-PLA2 in the sample; (B) hydrolyzing the lyso-PAFs produced in the step (A) with an enzyme (lyso-PAF-PLD) to obtain hydrolysate; and (C) measuring Lp-PLA2 activity in the sample by utilizing a quantitative change attributable to the hydrolysate obtained in step (B) as an indicator.
    Type: Application
    Filed: June 15, 2017
    Publication date: January 2, 2020
    Applicant: ASAHI KASEI PHARMA CORPORATION
    Inventors: Shinichi SAKASEGAWA, Saki YAMAURA, Daisuke SUGIMORI
  • Method of purifying polyunsaturated aliphatic compounds
    Patent number: 5189189
    Abstract: [Object] A fatty acid-related polyunsaturated compound can be selectively purified using an industrially operable successive method under moderate conditions. [Content] A highly purified fatty acid-related polyunsaturated compound is obtained by a process comprising steps of forming a complex with silver on account of the high degree of unsaturation of the fatty acid-related polyunsaturated compound, isolating the complex from other fats on account of the hydrophilicity of the complex and then applying dissociating procedures to the complex to obtain the fatty acid-related polyunsaturated compound as a target substance on account of the hydrophobicity of the fatty acid-related polyunsaturated compound. As to the procedures for dissociation, addition of a dissociating agent and reduction of silver are disclosed. As to the dissociating agent, various compounds which produce insoluble composition with silver other then water are disclosed.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: February 23, 1993
    Assignees: Harima Chemicals, Inc., Sagami Chemical Research Center
    Inventors: Yoshihisa Misawa, Hisao Kondo, Tetsuya Tsutsumi, Masahiro Hayashi, Daisuke Sugimori, Yorishige Matsuba, Masashi Isozaki, Hiroharu Nishigaki, Kazunaga Yazawa, Kiyosi Kondo