Abstract: The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process.

Abstract: There is provided a consumable supply method for supplying a refill consumable stored in a refill consumable container to a consumable container installable in an equipment body. The consumable supply method includes removing a refill information storage device storing information on the refill consumable from the refill consumable container; removing an information storage device storing information on a consumable contained in the consumable container, the information being for exchange with the equipment body, from the consumable container; and attaching the refill information storage device removed from the refill consumable container as an information storage device to the consumable container in place of the information storage device removed from the consumable container.

Abstract: An inductor component comprising an element body; and a coil in the element body and helically wound along an axial direction. The coil includes a first coil wiring wound along a plane orthogonal to the axial direction, a second coil wiring adjacent to the first coil wiring in the axial direction and wound along a plane orthogonal to the axial direction, and a via electrode connecting the first and second coil wirings. The first and second coil wirings have first and second thick portions, respectively, each having an aspect ratio greater than 1.00, and first and second thin portions, respectively, that are end portions of the first and second coil wirings having an average thickness smaller than the thickness of the first and second thick portions, respectively. The via electrode connects the first and second thin portions.

Abstract: A heat conductor includes a housing including a space therein, a working medium in the space, and a wick in the space. The housing includes a first region, a second region located at one side of the first region in one direction perpendicular to a thickness direction of the housing, and a third region located at another side of the first region in the one direction. The first region includes a first end portion connected to the second region, and a second end portion connected to the third region. The wick is only in the second region.

Abstract: An inductor component includes an element assembly; a coil inside the element assembly and helically wound along an axis; and first and second outer electrodes in the element assembly and electrically connected to the coil. The element assembly has insulating layers stacked along the axis. The coil has pieces of coil wiring stacked along the axis and via wiring extending along the axis and connecting the pieces of coil wiring adjacent in a direction of the axis. The pieces are each wound along a plane, are electrically connected in series in a helix, and have first and second coil wirings at a respective endmost on one and other sides in a direction parallel to the axis and respectively connected to the first and second outer electrodes. An end surface on the one side has an area smaller than that of an end surface on the other side.

Abstract: The present invention aims to provide a more stable and efficient method for producing oligonucleotide, particularly, oligonucleotide having various functional groups linked to the 3?-terminal and the like.

Abstract: An opening/closing direction restriction mechanism for a manual shutter device and an opening/closing direction restriction mechanism for a suspended sliding door device This opening/closing direction restriction mechanism is provided with: a flange fixedly mounted on a fixed shaft; a bracket which is loosely fitted to the fixed shaft and can be integrally rotated with a winding member; and a two-way clutch which can be switched between a reverse rotation inhibited state in which the revolution of a planetary external gear along a winding direction of the winding member is allowed and the revolution of the planetary external gear along an unwinding direction is inhibited, and a forward rotation inhibited state in which the revolution of the planetary external gear along the winding direction of the winding member is inhibited and the revolution of the planetary external gear along the unwinding direction is allowed.

Abstract: A method for producing a cyclic peptide, including the following step (1) and step (2): (1) a step of cyclizing a linear peptide; and (2) a step of obtaining a cyclic peptide by adding a poor solvent to a mixture of the cyclic peptide and multimeric impurity, which mixture is obtained in the above-mentioned step, and filtering off the multimeric impurity as an insoluble material can efficiently remove multimeric impurity by-produced during a cyclization reaction, improve the purity of the obtained cyclic peptide, and reduce a burden on the purification step.

Abstract: This notification device (100) of a notification system (10) detects a portion of the body of a person from distance information from a proximity sensor (110) and image information from an image sensor (120) when an approaching object is a person, and causes an ultrasonic irradiation device (130) to irradiate the detected portion of the body of the person with ultrasonic waves that can generate tactile sensation.

Abstract: Updating performance of a display screen in a terminal device that displays a screen for remotely monitoring an object to be controlled by a control device is appropriately maintained. An information device for factory automation connected to the control device that controls an object communicates with a terminal device having a display capable of displaying a screen for remotely monitoring the control device. The screen includes one or more components. The screen data for displaying the screen includes attributes of the respective components relating to the display, and a logic executed by the programmable indicator to determine the attribute values. When the terminal device displays a screen, the programmable indicator transmits the attributes and attribute values of the respective components in the screen data to the terminal device.

Abstract: A management server controls, by use of a first database, a first audio client system that includes a first speaker and a second speaker. The first database includes a first standard characteristic impedance, which is obtained by application of statistical processing to a first characteristic impedance of the first speaker and a second characteristic impedance of the second speaker. The management server acquires a new characteristic impedance of the first speaker, compares the new first characteristic impedance with the first standard characteristic impedance, to determine a condition of the first speaker, based on a result of the comparison. The management server updates, based on the condition of the first speaker, the first standard characteristic impedance of the first database, using the new first characteristic impedance.

Abstract: Formation of a modified oligonucleotide by treating four or more oligonucleotide raw material fragments in total in the presence of an oligonucleotide ligase; the four or more oligonucleotide raw material fragments in total corresponding to oligonucleotide raw material fragments that are obtained by dividing the modified oligonucleotide at a fragment linking site that satisfies following conditions (i) to (v): (i) one or more fragment linking sites are present in the complementary portion in each strand side, and two or more fragment linking sites in total are present in the modified oligonucleotide; (ii) when the modified oligonucleotide is divided at the fragment linking site, a sticky end is formed in the complementary portion, in which the sticky end has 1 to 10 nucleotide length; (iii) at least one oligonucleotide raw material fragment has a modified nucleotide; (iv) four oligonucleotide raw material fragments out of the four or more oligonucleotide raw material fragments in total include the complementa

Abstract: Peptides may be continuously produced by a method including the following steps (1), (A), (2), and (B): (1) performing a condensation reaction in a flow reactor to obtain an N-protected C-protected peptide in which an N-terminal amino group and C-terminal are protected by protecting groups, a side chain functional group is optionally further protected by a protecting group, and at least one of the C-terminal or the side chain functional group is protected by a pseudo-solid-phase protecting group (N-protected C-protected peptide), (A) washing a reaction mixture containing an N-protected C-protected peptide in a flow reactor and separating oil and water to separate an organic layer containing the N-protected C-protected peptide, (2) subjecting an organic layer containing an N-protected C-protected peptide to a reaction to remove a protecting group of an N-terminal amino group in a flow reactor to obtain a C-protected peptide in which an N-terminal amino group is not protected, C-terminal is protected by a pr

Abstract: An image forming apparatus includes a photoconductor, a charger, a charge remover, and control circuitry. The charger is configured to charge the photoconductor. The charge remover is configured to remove charge from a surface of the photoconductor by light and electric discharge. The control circuitry is configured to: estimate a surface potential that the photoconductor has after the photoconductor is charged by the charger, based on a characteristic value of the photoconductor and a value of a current flowing through the charger after the charge remover removes charge from the photoconductor; and control a charging bias applied to the charger, based on the surface potential estimated.

Abstract: A method including obtaining a phosphite form or a phosphorous acid diester form by coupling a nucleoside, nucleotide or oligonucleotide wherein a 5?-hydroxy group is not protected, and other group is optionally protected by a protecting group used for nucleic acid synthesis or bonded to a solid phase carrier, and a nucleoside, nucleotide or oligonucleotide wherein a 3?-hydroxy group or a 3?-amino group is modified by a method for forming a phosphite form or a phosphorous acid diester form, and other group is optionally protected by a protecting group used for nucleic acid synthesis in the presence of an antioxidant is useful for producing an oligonucleotide having a phosphorothioated site.

Abstract: A method for producing an oligonucleotide, including a step of removing a temporary protecting group of a 5?-hydroxyl group by adding an acid to a protected oligonucleotide having a phosphorothioate (PS), phosphate (PO) or H-phosphonate moiety, and deacylating a by-product having an acylated 5?-hydroxyl group by solvolysis can complete a condensation reaction to improve a condensation yield, and can markedly reduce impurities such as single base deletion form (N-1mer) and the like.

Abstract: Provided is a braking device configured to release a cord in a non-bent state so that the operation force required to pull cords is reduced and the behavior of slats is stabilized during an automatic fall, and a sunlight shielding device using the braking device. A braking device for braking movement of a cord includes a movement converter configured to convert movement of a cord into movement of another member. The movement converter includes sandwiching object configured to allow the cord to be sandwiched. The sandwiching object is configured to change a sandwiched state so that the cord is sandwiched by the sandwiching object when the cord and the sandwiching object move relatively in one direction and the cord is released in a non-bent state when the cord and the sandwiching object move relatively in another direction.

Abstract: There is provided a hinge arm damper mechanism that reliably achieves a damper effect corresponding to a braking force of an elastic member. The hinge arm damper mechanism is configured to include a pinion gear, a pair of racks and, two sets of heavy load springs and, a pair of slide bars and, and a housing. The housing includes a box-shaped case and a plate-shaped cover. The case accommodates the pinion gear, the pair of racks and, the two sets of heavy load springs and, and the pair of slide bars and. A rotational torque applied to a hinge arm is transmitted to the racks and via a rotational motion of the pinion gear, and is converted into a linear motion of the racks and. The linear motion of the racks and is reliably braked by the respective springs and.

Abstract: A reverse input lock clutch has a fitting portion of a spring stopper rotatably fitted in a cylindrical dent formed by being surrounded by an inner diameter portion on an end surface of an output member on a side opposite to a fixed member. A locking portion rotates with the fitting portion while having one end of a first elastic member locked by a holder groove. Adjustment of the rotation position of the lock portion with respect to the output member is made by rotating the fitting portion within a range of a groove length of an adjustment groove with respect to the output member and anchoring an adjustment pin at a desired rotation position to the adjustment pin fixing portion so as to fix the fitting portion on the output member.