Abstract: The present invention provides a production method of a protected amino acid, protected peptide or peptide, including precipitation and solid-liquid separation of C-protected amino acid or C-protected peptide in a solvent containing water-containing acetonitrile, after removing the N-terminal protecting group from N-protected C-protected amino acid or N-protected C-protected peptide wherein the C-terminal carboxy group is protected by an anchor group.

Abstract: The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH??(I) wherein L is a C1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II): Fm—S-L-COOH??(II) wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

Abstract: An image forming apparatus includes an image carrier, a transfer unit, and a control unit. The image carrier has a surface to bear a toner image thereon. The transfer unit has a transfer member to transfer the toner image onto a recording sheet conveyed in a conveyance direction for trailing-end borderless image formation and duplex image formation. The transfer unit is configured to form the toner image on the recording sheet without forming a margin at a trailing end of the recording sheet in the conveyance sheet in the trailing-end borderless image formation. The transfer unit is configured to form the toner image on front and back faces of the recording sheet in the duplex image formation. When a width of the toner image formed in a borderless image area of the recording sheet in the trailing-end borderless image formation is smaller in a direction perpendicular to the conveyance direction than a threshold value, the control unit permits the duplex image formation.

Abstract: Using a morpholino nucleotide wherein 5?-hydroxy group or a hydroxy group present on the substituent of the 5?-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided.

Abstract: The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.

Abstract: The present invention provides a protecting reagent that can be removed in a high yield even under acidic conditions and can afford a resulting product at a high purity in an organic synthesis reaction such as peptide synthesis and the like. The inventive protecting reagent is particular benzylic compound having only one hydroxyl group substituted by an organic group having an aliphatic hydrocarbon group having a carbon number of not less than 14.

Abstract: A crimp terminal that can maintain excellent water-stop performance over a long term and is enhanced in joint strength between a fitting portion and a covered electrical wire connection portion. The crimp terminal has a fitting portion at a tip thereof and an electrical wire connection portion at a rear end thereof, the electrical wire connection portion is configured in a tubular shape, a tip of the tube is crushed to be superimposed and closed, and a portion between the fitting portion and the electrical wire connection portion is formed by superimposing and bending two or more sheets of a plate material.

Abstract: The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.

Abstract: A portable electronic device according to the present invention is provided with a casing formed by joining two cabinets together. A housing chamber for an electric component is recessed on at least either one cabinet and is open toward an inner face of the other cabinet. Mating surfaces located on both the cabinets overlap each other around the housing chamber. A water entry portion leading to a clearance between the mating surfaces is located on an exposed surface exposed to the outside of the casing in an upper part of the casing. A groove extending in a right-left direction along the hosing chamber is recessed on the mating surface of at least either one cabinet of the two cabinets at a position away upward from the housing chamber.

Abstract: A fuel injection apparatus includes an injector that injects fuel into a combustion chamber or an intake port of an internal combustion engine; an injection amount controller that controls a fuel injection amount of the injector and corrects the fuel injection amount to increase when the internal combustion engine is in a given cold state; an air-fuel ratio detector that detects an air-fuel ratio of the internal combustion engine; and an air-fuel ratio rich fault determiner that determines an air-fuel ratio rich fault when the air-fuel ratio exists on a rich side than a predetermined determination value. The air-fuel ratio rich fault determiner shifts the predetermined determination value toward the rich side in accordance with the increasing correction of the fuel injection amount so as to correct the predetermined determination value.

Abstract: An image forming apparatus includes at least one image bearer; multiple developing devices to develop the latent images with developers including toner and carrier into a toner image; multiple developer supply devices to supply the developers to the multiple developing devices, respectively; and a fixing device to fix the toner image on a sheet of recording media. When one of the multiple developing devices positioned at a shortest distance from an outline of the fixing device is referred to as a first developing device, and one of the multiple developer supply devices that supplies developer to the first developing device is referred to as a first developer supply device, the first developer supply device is greater in percentage by weight of carrier in developer supplied to the first developing device than rest of the multiple developer supply devices.

Abstract: An engine misfiring diagnosis device includes: a misfiring diagnosis value calculator that calculates a misfiring diagnosis value for determination of misfiring, based on an amount of rotational fluctuations among cylinders; a reference determination threshold calculator that calculates a reference determination threshold for determining occurrence of misfiring, based on an engine operating state; a first misfiring determiner that compares the misfiring diagnosis value with the reference determination threshold, and determines misfiring of a cylinder being diagnosed; and a second misfiring determiner that, if the first misfiring determiner has determined misfiring is occurring, performs re-determination regarding misfiring for the cylinder being diagnosed, based on a difference between a value obtained by correcting the misfiring diagnosis value of the cylinder being diagnosed with a rotational fluctuation correction value based on the engine operating state, and the misfiring diagnosis values of the cylinder

Abstract: An adhesive laminate having excellent adhesiveness required for attachment to a structural member. The adhesive laminate comprises (A) a light-transmitting substrate layer (layer A) formed from a melt extruded thermoplastic resin, (B) a hard coat layer (layer B) formed by using a hard coating agent containing not less than 10 wt % of colloidal silica and/or an alkoxysilane hydrolysis condensate based on the total weight of the hard coat excluding a solvent, (C) an adhesive primer layer (layer C) and GK228PCT-13-5-2 and is to be attached to a structural member, wherein (i) the layers A to D are formed in this order; (ii) the layer C is formed from a primer composition comprising a silane coupling agent and has a thickness of 1 to 20 ?m and an indentation elasticity modulus measured by a nano-indentation method under a load of 800 ?N of 500 to 4,000 MPa; and (iii) the thickness (Y) of the layer D is 0.

Abstract: Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

Abstract: The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3?-position.

Abstract: The present invention provides a protecting reagent that can be removed in a high yield even under acidic conditions and can afford a resulting product at a high purity in an organic synthesis reaction such as peptide synthesis and the like. The inventive protecting reagent is particular benzylic compound having only one hydroxyl group substituted by an organic group having an aliphatic hydrocarbon group having a carbon number of not less than 14.

Abstract: The present invention provides a protecting reagent that can be removed in a high yield even under acidic conditions and can afford a resulting product at a high purity in an organic synthesis reaction such as peptide synthesis and the like. The inventive protecting reagent is particular benzylic compound having only one hydroxyl group substituted by an organic group having an aliphatic hydrocarbon group having a carbon number of not less than 14.

Abstract: The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH??(I) wherein L is a C1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II): Fm-S-L-COOH??(II) wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

Abstract: The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3?-position.

Abstract: The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.