Abstract: The present invention aims at providing NOX inhibitors and NF?B inhibitors having superior actions, as well as agents for preventing or treating NOX- or NF?B-associated diseases that utilize such inhibitors. To this end, specified methoxyflavones are employed.

Abstract: An object is to improve a trap effect to trap ignition fuel gas supplied to a pre-combustion chamber and reduce an amount of non-combusted ignition fuel gas flowing out of the pre-combustion chamber to suppress a decrease in combustion efficiency. A pre-combustion-chamber type gas engine includes: a pre-combustion chamber Sr disposed on a cylinder head portion 10; a spark plug 20 disposed on an upper part of the pre-combustion chamber Sr; a pre-combustion-chamber gas supply mechanism configured to supply ignition fuel gas “g” to the pre-combustion chamber Sr via gas supply channels for the pre-combustion chamber 22a and 22b with an opening on an upper part of the pre-combustion chamber Sr; and a check valve 24 disposed in the gas supply channel 22b for the pre-combustion chamber.

Abstract: Disclosed is an oil jet device for cooling a piston, including: an oil cooler 4 that is disposed upstream of an oil injection nozzle 8; an oil pump 5 that is disposed upstream of the oil cooler 4; a first switching adjustment valve 6 that is disposed between the oil injection nozzle 8 and the oil cooler 4 and adjusts a flow dividing ratio at which the cooling oil from the oil cooler 4 is distributed to the oil injection nozzle 8 side and to an oil pan side; and a control unit that has an oil quantity adjustment map 4 for switching the first switching adjustment valve 6 based on a piston temperature calculation map 20 for calculating the temperature of the piston 1 using detection values acquired respectively by a cooling water temperature sensor 35, a rotation speed sensor 36 and a load sensor 37.

Abstract: The present invention relates to a composition containing riboflavin and a sesamin-class compound(s). This composition may incorporate a sesamin-class compound (s) in such an amount that the proportion (weight ratio) of its total quantity to the total quantity of riboflavin taken as unity is no more than 4.5, and it has the advantage that the analgesic and anti-fatigue actions of riboflavin are synergistically improved by ingestion of riboflavin in combination with a sesamin-class compound(s). The composition of the present invention provides compositions, in particular, pharmaceuticals as well as foods and beverages that are safe to humans, animals, etc. and can therefore be ingested for a continued period, and which have far superior effects to those of conventional foods having an analgesic or anti-fatigue action.

Abstract: A composition incorporating at least one sesamin-class compound is enhanced in the anti-fatigue action of sesamin class compounds by additionally incorporating at least one vitamin B1 class compound. Also provided is an anti-fatigue agent containing at least one sesamin-class compound and at least one vitamin B1 class compound as the active ingredients.

Abstract: A method by which the physiological activities of sesamin-class compounds can be efficiently exhibited and enhanced, as well as an effective compound that can be combined with the sesamin-class compounds to this end. By using sesamin-class compounds in combination with more than specified proportions of arachidonic acid class compounds, the physiological activities of the sesamin-class compounds, for example, their anti-fatigue action is synergistically enhanced to provide compositions that are safe in humans and non-human animals and which hence can be ingested continuously.

Abstract: Disclosed is an oil jet device for cooling a piston, including: an oil cooler 4 that is disposed upstream of an oil injection nozzle 8; an oil pump 5 that is disposed upstream of the oil cooler 4; a first switching adjustment valve 6 that is disposed between the oil injection nozzle 8 and the oil cooler 4 and adjusts a flow dividing ratio at which the cooling oil from the oil cooler 4 is distributed to the oil injection nozzle 8 side and to an oil pan side; and a control unit that has an oil quantity adjustment map 4 for switching the first switching adjustment valve 6 based on a piston temperature calculation map 20 for calculating the temperature of the piston 1 using detection values acquired respectively by a cooling water temperature sensor 35, a rotation speed sensor 36 and a load sensor 37.

Abstract: A method by which the physiological activities of sesamin-class compounds can be efficiently exhibited and enhanced, as well as an effective compound that can be combined with the sesamin-class compounds to this end. By using sesamin-class compounds in combination with more than specified proportions of arachidonic acid class compounds, the physiological activities of the sesamin-class compounds, for example, their anti-fatigue action is synergistically enhanced to provide compositions that are safe in humans and non-human animals and which hence can be ingested continuously.

Abstract: A composition incorporating at least one sesamin-class compound is enhanced in the anti-fatigue action of sesamin class compounds by additionally incorporating at least one vitamin B1 class compound. Also provided is an anti-fatigue agent containing at least one sesamin-class compound and at least one vitamin B1 class compound as the active ingredients.

Abstract: The present invention relates to a composition containing riboflavin and a sesamin-class compound(s). This composition may incorporate a sesamin-class compound(s) in such an amount that the proportion (weight ratio) of its total quantity to the total quantity of riboflavin taken as unity is no more than 4.5, and it has the advantage that the analgesic and anti-fatigue actions of riboflavin are synergistically improved by ingestion of riboflavin in combination with a sesamin-class compound(s). The composition of the present invention provides compositions, in particular, pharmaceuticals as well as foods and beverages that are safe to humans, animals, etc. and can therefore be ingested for a continued period, and which have far superior effects to those of conventional foods having an analgesic or anti-fatigue action.