Abstract: A lower vehicle-body structure of a vehicle may include: a floor panel; a side sill; and a frame member that extends in the front-rear direction on the vehicle-width-direction inner side of the side sill and includes a front-rear extended portion that is in abutment against the side sill on the vehicle-width-direction inner side and extends in the vehicle front-rear direction along the side sill. The front-rear extended portion may include: a bottom face portion; an inner wall portion; and an inner-side flange that extends to the vehicle-width-direction inner side from a distal end portion of the inner wall portion and is joined to the floor panel. Deformation facilitating facilitators that facilitate deformation of the bottom face portion in the vehicle width direction when a collision load in the vehicle width direction is input may be formed in the bottom face portion.

Abstract: A system and method control an automobile by decelerating the automobile at a first deceleration using a braking mechanism in response to detecting that a parking brake switch is turned on, a second deceleration which is smaller than the first deceleration, in response to not detecting that the parking brake switch is turned on and determining that the driver is incapacitated, and a third deceleration which is smaller than the first deceleration, in response to determining that an SOS switch is turned on, detecting that the parking brake switch is changed from on to off, and not determining that the driver is incapacitated.

Abstract: A lower structure for a vehicle includes a battery unit which is provided under a vehicle body floor, a frame member which extends in a front-rear direction on a vehicle-width-direction outer side of the battery unit, a high-voltage cable which extends forward from a front portion of the battery unit, and a fixing member which fixes a rear portion of the battery unit to the frame member, and the fixing member is configured to be fractured when an inward collision load in a vehicle width direction is input to a position in front of a position of a center of gravity of a first battery unit.

Abstract: There are provided a pair of side sills provided at both outward sides, in a vehicle width direction, of a vehicle body and extending in a vehicle longitudinal direction, first and second battery units provided below a floor panel on respective inward sides, in the vehicle width direction, of and adjacently to the side sills, the first and second battery units being spaced apart from each other in the vehicle width direction, and a connecting member interconnecting the first and second battery units. The connecting member comprises a vehicle-width-direction connection portion to interconnect the first and second battery units so as to transmit a load, in the vehicle width direction, therebetween and plural deformation promotion portions provided adjacently to the vehicle-width-direction connection portion so as to cause deformation at the vehicle-width-direction connection portion when receiving the load caused by a vehicle side collision.

Abstract: A lower vehicle-body structure of a vehicle may include: a floor panel; a side sill; and a frame member that extends in the front-rear direction on the vehicle-width-direction inner side of the side sill and includes a front-rear extended portion that is in abutment against the side sill on the vehicle-width-direction inner side and extends in the vehicle front-rear direction along the side sill. The front-rear extended portion may include: a bottom face portion; an inner wall portion; and an inner-side flange that extends to the vehicle-width-direction inner side from a distal end portion of the inner wall portion and is joined to the floor panel. Deformation facilitating facilitators that facilitate deformation of the bottom face portion in the vehicle width direction when a collision load in the vehicle width direction is input may be formed in the bottom face portion.

Abstract: The lower structure of an electric vehicle includes: an automatic transmission provided below a floor panel and in an intermediate portion in a right-left direction thereof; an inverter arranged between the automatic transmission and a floor side frame; and an attachment bracket for attaching the inverter to the floor panel. The attachment bracket has an outer shell structure including: an inner wall portion dividing the inverter and the automatic transmission; an outer wall portion dividing the inverter and the floor side frame; an upper wall portion; and a lower wall portion.

Abstract: A vehicle-body structure that effectively distributes and transfers a side collision load in the vehicle width direction. A cross member includes a cross member top face facing a floor panel, and a cross member front face and a cross member rear face extending from respective ends in a front-rear direction of the cross member top face to the floor panel. A reinforcement member is at a side sill-side end of the cross member top face of the cross member, and a fragile portion extending in the vehicle front-rear direction is provided at a position at a side sill-side end of the cross member and overlapping the reinforcement member. The fragile portion is selected from a cutout, a bead, and a hole. The reinforcement member is a seat mounting bracket, and the fragile portion is on a vehicle-width-direction outer side of a seat mounting surface of the seat mounting bracket.

Abstract: This semiconductor device is formed by stacking a plurality of semiconductor chips that each have a plurality of bump electrodes, each of the plurality of semiconductor chips being provided with an identification section formed on a respective side face. Each semiconductor chip has a similar arrangement for its respective plurality of bump electrodes, and each identification section is formed so that the positional relationship with a respective reference bump electrode provided at a specific location among the respective plurality of bump electrodes is the same in each semiconductor chip. The plurality of semiconductor chips are stacked such that the bump electrodes provided thereon are electrically connected in the order of stacking of the semiconductor chips, while the side faces on which the identification sections are formed are oriented in the same direction.

Abstract: A vehicle-body structure that effectively distributes and transfers a side collision load in the vehicle width direction. A cross member includes a cross member top face facing a floor panel, and a cross member front face and a cross member rear face extending from respective ends in a front-rear direction of the cross member top face to the floor panel. A reinforcement member is at a side sill-side end of the cross member top face of the cross member, and a fragile portion extending in the vehicle front-rear direction is provided at a position at a side sill-side end of the cross member and overlapping the reinforcement member. The fragile portion is selected from a cutout, a bead, and a hole. The reinforcement member is a seat mounting bracket, and the fragile portion is on a vehicle-width-direction outer side of a seat mounting surface of the seat mounting bracket.

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified ?-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the ?-subunit of wild-type human ?-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.

Abstract: This semiconductor device is formed by stacking a plurality of semiconductor chips that each have a plurality of bump electrodes, each of the plurality of semiconductor chips being provided with an identification section formed on a respective side face. Each semiconductor chip has a similar arrangement for its respective plurality of bump electrodes, and each identification section is formed so that the positional relationship with a respective reference bump electrode provided at a specific location among the respective plurality of bump electrodes is the same in each semiconductor chip. The plurality of semiconductor chips are stacked such that the bump electrodes provided thereon are electrically connected in the order of stacking of the semiconductor chips, while the side faces on which the identification sections are formed are oriented in the same direction.

Abstract: This semiconductor device is formed by stacking a plurality of semiconductor chips that each have a plurality of bump electrodes, each of the plurality of semiconductor chips being provided with an identification section formed on a respective side face. Each semiconductor chip has a similar arrangement for its respective plurality of bump electrodes, and each identification section is formed so that the positional relationship with a respective reference bump electrode provided at a specific location among the respective plurality of bump electrodes is the same in each semiconductor chip. The plurality of semiconductor chips are stacked such that the bump electrodes provided thereon are electrically connected in the order of stacking of the semiconductor chips, while the side faces on which the identification sections are formed are oriented in the same direction.

Abstract: Provided is a modified ?-subunit of human ?-hexosaminidase which has the activity derived from the ?-subunit of wild-type human ?-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a ?-subunit of wild-type human ?-hexosaminidase.

Abstract: A motive power stoppage guidance apparatus includes at least one of a display device configured to be disposed in a compartment of a vehicle, and a sound output device configured to output a sound in the compartment of the vehicle; and an indication control unit configured, when the vehicle is traveling in a state where a motive power stops, or when the likelihood is high in that the vehicle is traveling in the state where the motive power stops, to execute at least one of having the display device display at least one of that the motive power is in a stopped state, and a recommended operational method, and having the sound output device output an indication sound.

Abstract: This semiconductor device is formed by stacking a plurality of semiconductor chips that each have a plurality of bump electrodes, each of the plurality of semiconductor chips being provided with an identification section formed on a respective side face. Each semiconductor chip has a similar arrangement for its respective plurality of bump electrodes, and each identification section is formed so that the positional relationship with a respective reference bump electrode provided at a specific location among the respective plurality of bump electrodes is the same in each semiconductor chip. The plurality of semiconductor chips are stacked such that the bump electrodes provided thereon are electrically connected in the order of stacking of the semiconductor chips, while the side faces on which the identification sections are formed are oriented in the same direction.

Abstract: Provided is a modified ?-subunit of human ?-hexosaminidase which has the activity derived from the ?-subunit of wild-type human ?-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a ?-subunit of wild-type human ?-hexosaminidase.

Abstract: A motive power stoppage guidance apparatus includes at least one of a display device configured to be disposed in a compartment of a vehicle, and a sound output device configured to output a sound in the compartment of the vehicle; and an indication control unit configured, when the vehicle is traveling in a state where a motive power stops, or when the likelihood is high in that the vehicle is traveling in the state where the motive power stops, to execute at least one of having the display device display at least one of that the motive power is in a stopped state, and a recommended operational method, and having the sound output device output an indication sound.

Abstract: According to one embodiment, a cladding portion is integrally formed on a sliding-contact surface of a valve rod or a valve body, which serves as a movable member, wherein the cladding portion is formed by inducing a pulsed discharge between an electrode which is formed of a molded body consisting mainly of a metal and a treatment target portion of the valve rod or the valve body, so as to weld and deposit a material of the electrode on a surface of the treatment target portion. A surface layer is integrally formed on a sliding-contact surface of a bushing or a sleeve, which serves as a stationary member, wherein the surface layer is formed by forming a first coating film by surface-hardening heat treatment using a metallic cementation.

Abstract: The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a differentiation of an undifferentiated cell into a nervous system cell with high selectivity. In addition, the objective of the present invention is to provide use of a specific catechol derivative for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity, and a method for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity using a specific catechol derivative. The cell differentiation inducer of the present invention is characterized in comprising the catechol derivative having the specific chemical structure.

Abstract: The objective of the present invention is to provide a new compound which is effective in treating blood cancer, particularly multiple myeloma, and which is also effective in suppressing an SP cell, i.e. Side Population Cell, which is a cause of recurrence of cancer. The compound according to the present invention is a novel compound which has the specific benzylamine structure.