Patents by Inventor Daisy Joe

Daisy Joe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FK-506 type macrolide intermediate
    Patent number: 5235066
    Abstract: An intermediate, useful in the conversion of FK-506 to FK-525 and analogous 23-membered ring macrolides, of the structure: ##STR1##
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: August 10, 1993
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Daisy Joe, Ralph P. Volante, Ichiro Shinkai
  • Synthetic process for FK-506 type macrolide intermediates
    Patent number: 5164525
    Abstract: A process for the conversion of FK-506 (I,R=allyl;1) to FK-525 (XV) and analogous 23-membered ring macrolides differing in the C.1-N.7 segment of the molecule (e.g. XVI) and is also applicable to the analogs FK-523 (XVII) and FK-520 (XVIII). The overall process consists of three stages: (a) initial degradation of the primary macrolide to an acyclic fragment containing a selectively protected C.10-C.34 framework with a protected aldehyde function at C.10 and a free hydroxyl function at C.26, (b) reacylation of the C.26 hydroxyl function with an appropriately N-protected alpha-amino acid moiety, and (c) reintroduction of the C.8 and C.9 carbons followed by regeneration of the FK-macrolide system.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: November 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Ralph P. Volante, Daisy Joe, Ichiro Shinkai