Patents by Inventor Daisy Joe

Daisy Joe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolopyrazine kinase inhibitors
    Patent number: 8119636
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: February 21, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Yan Lou, Timothy D. Owens, David Bernard Smith
  • Pyrrolopyrazine kinase inhibitors
    Patent number: 8008298
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: August 30, 2011
    Assignee: Roche Palo Alto
    Inventors: Joe Timothy Bamberg, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Alam Jahangir, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, David Bernard Smith, Michael Soth, Hanbiao Yang
  • Tetrazole-substituted aryl amide derivatives and uses thereof
    Patent number: 7981914
    Abstract: Compounds of the formula: wherein R1, R2, Ar1, Ar2, and n are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 19, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Todd Richard Elworthy, Hans Maag, Sunil Sahdeo
  • Pyrrolopyrazine kinase inhibitors
    Patent number: 7939531
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: May 10, 2011
    Assignee: Roche Palo Alto
    Inventors: Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee
  • Pyrrolopyrazine kinase inhibitors
    Patent number: 7932254
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1 and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 26, 2011
    Assignee: Roche Palo Alto
    Inventors: Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Yan Lou, Timothy D. Owens, Calvin Wesley Yee
  • INDOLE DERIVATIVES AS CRAC MODULATORS
    Publication number: 20110071150
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).
    Type: Application
    Filed: September 23, 2010
    Publication date: March 24, 2011
    Inventors: Muzaffar Alam, Daisy Joe Du Bois, Ronald Charles Hawley, Joshua Kennedy-Smith, Ana Elena Minatti, Wylie Solang Palmer, Tania Silva, Robert Stephen Wilhelm
  • Pyrrolopyrazine kinase inhibitors
    Publication number: 20100267666
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: February 20, 2009
    Publication date: October 21, 2010
    Inventors: Joe Timothy Bamberg, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Alam Jahangir, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, David Bernard Smith, Michael Soth, Hanbiao Yang
  • AZAINDOLE P2X3 AND P2X2/3 MODULATORS
    Publication number: 20100144758
    Abstract: The application discloses compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein, X, R1, R2 R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 10, 2010
    Inventors: Michael Patrick Dillon, Daisy Joe Du Bois, Yingjie Lai, Ronald Charles Hawley, Beihan Wang
  • Cyclopropyl aryl amide derivatives and uses thereof
    Patent number: 7723391
    Abstract: Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: May 25, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst
  • Pyrrolopyrazine kinase inhibitors
    Publication number: 20090215750
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 27, 2009
    Inventors: Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee
  • Pyrrolopyrazine kinase inhibitors
    Publication number: 20090215785
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 27, 2009
    Inventors: Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Raman K. Kondru, Yan Lou, Timothy D. Owens, David Bernard Smith
  • Pyrrolopyrazine kinase inhibitors
    Publication number: 20090215724
    Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1 and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 27, 2009
    Inventors: Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Yan Lou, Timothy D. Owens, Calvin Wesley Yee
  • Tetrazole-substituted aryl amide derivatives and uses thereof
    Publication number: 20090093523
    Abstract: Compounds of the formula: wherein R1, R2, Ar1, Ar2, and n are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 9, 2009
    Inventors: Daisy Joe Du Bois, Todd Richard Elworthy, Hans Maag, Sunil Sahdeo
  • Cyclopropyl aryl amide derivatives and uses thereof
    Publication number: 20090093525
    Abstract: Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Application
    Filed: October 2, 2008
    Publication date: April 9, 2009
    Inventors: Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst
  • Diaminopyrimidines as P2X3 and P2X2/3 modulators
    Publication number: 20080207655
    Abstract: Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.
    Type: Application
    Filed: February 27, 2008
    Publication date: August 28, 2008
    Inventors: Michael Patrick Dillon, Daisy Joe Du Bois, Alam Jahangir
  • CCR-3 receptor antagonists
    Patent number: 7049317
    Abstract: The invention provides compounds of Formula (I): wherein R1–R4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: May 23, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventor: Daisy Joe Du Bois
  • CCR-3 receptor antagonists (I)
    Patent number: 7019007
    Abstract: The invention provides compounds of Formula (I): wherein: R1–R4, A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: March 28, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Daisy Joe Du Bois, Beihan Wang
  • 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists
    Patent number: 6984643
    Abstract: Compounds of Formula (I): wherein Ar1 is aryl; Ar2 is hydrogen, cycloalkyl, aryl or heteroaryl; Z is —C(?O) or a single bond; R1, R2, R3, R4 and R5 are independently hydrogen or alkyl optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon atoms; X is —O—, —NRh (where Rh is hydrogen or alkyl), (CR6R7)m(where R6 and R7 are independently in each occurrence hydrogen or alkyl and m is an integer from 0 to 3), or —S(O)n (wherein n is an integer from 0 to 2); or prodrugs thereof, and pharmaceutically acceptable salts thereof, are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: January 10, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Long Mao, Daniel Harry Rogers, John Patrick Williams
  • Piperidine CCR-3 receptor antagonists
    Patent number: 6977265
    Abstract: The invention provides compounds of Formula (I): wherein: R1-R5, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: December 20, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang
  • Piperazine CCR-3 receptor antagonists
    Patent number: 6906073
    Abstract: The invention provides compounds of Formula (I): wherein: R1-R4, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: June 14, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, Denis John Kertesz, Eric Brian Sjogren, David Bernard Smith, Beihan Wang