Patents by Inventor Daizhou ZHANG

Daizhou ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • glycerylphosphorylethanolamine (GPE) compound and lipid nanoparticle (LNP)-based drug carrier with same
    Publication number: 20250084051
    Abstract: A glycerylphosphorylethanolamine (GPE) skeleton compound and a lipid nanoparticle (LNP)-based drug carrier with the same are provided. The GPE skeleton compound has a structure shown in formula (I): A dithiolane structure is modified on a hydrophilic phosphate terminus of the GPE, such that the dithiolane structure is more fully exposed on a surface of the LNP, and the surface of the LNP can expose more dithiolane, thereby further promoting endocytosis of the LNP by mucosal cells. The GPE skeleton compound has a wide adjustment range in an LNP formulation and can increase a content of the dithiolane in the LNP. A nucleic acid-LNP composition and a pharmaceutical preparation are further provided, and can be used for ocular delivery, pulmonary inhalation delivery, and nasal spray of nucleic acid drugs, providing a new option for extrahepatic delivery of the nucleic acid drugs.
    Type: Application
    Filed: September 4, 2024
    Publication date: March 13, 2025
    Inventors: Song XUE, Daizhou ZHANG, Dawei LI, Xuehua YANG, Zhengping LIU, Jie ZHUANG
  • Joint cavity injection preparation and use thereof
    Patent number: 11376274
    Abstract: A joint cavity injection preparation is provided. The active ingredient of the joint cavity injection preparation is deacetylated xanthan gum (XG). The deacetylated XG has a molecular weight of 500,000 to 20,000,000. The joint cavity injection preparation is prepared from deacetylated xanthan gum (XG), which has higher biocompatibility and safe wide-dosage range than existing joint cavity injection preparations prepared from XG.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: July 5, 2022
    Assignees: SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES, SHANDONG FREDA PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Peixue Ling, Fei Liu, Huarong Shao, Lei Chen, Zhiyun Zhang, Xiaoyuan Zhang, Qixin Chen, Guanying Han, Yanling Cheng, Jianqiang Zhang, Daizhou Zhang
  • JOINT CAVITY INJECTION PREPARATION AND USE THEREOF
    Publication number: 20210353662
    Abstract: A joint cavity injection preparation is provided. The active ingredient of the joint cavity injection preparation is deacetylated xanthan gum (XG). The deacetylated XG has a molecular weight of 500,000 to 20,000,000. The joint cavity injection preparation is prepared from deacetylated xanthan gum (XG), which has higher biocompatibility and safe wide-dosage range than existing joint cavity injection preparations prepared from XG.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 18, 2021
    Applicants: SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES, SHANDONG FREDA PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Peixue LING, Fei LIU, Huarong SHAO, Lei CHEN, Zhiyun ZHANG, Xiaoyuan ZHANG, Qixin CHEN, Guanying HAN, Yanling CHENG, Jianqiang ZHANG, Daizhou ZHANG