Patents by Inventor Dajian Yang

Dajian Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140235877
    Abstract: The present invention provides two compounds, namely Compound A and B, as the potential anticancer drug, and a composition comprising said Compound A and/or B for treating cancer or tumor related diseases. The present invention also relates to methods of preparing the compounds from a natural source and a composition comprising the compounds, and using the same for treating cancer or tumor related diseases.
    Type: Application
    Filed: March 31, 2014
    Publication date: August 21, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Zhengxiang XIA, Yuanzhi LAO, Hongsheng TAN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Kaixian CHEN, Albert Sun-Chi CHAN
  • Publication number: 20140200265
    Abstract: This invention relates to the use of a natural compound from natural sources for its therapeutic uses. More particularly, it relates to a compound 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TI, FIG. 1), that is naturally occurring in the plant of Garcinia esculenta Y. H. Li, and its biological activity of inhibiting nitric oxide production and microRNA 155 expression in stimulated macrophages, which can be developed as potential anti-inflammatory drugs.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 17, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi Xu, Dandan Zhang, Hong Zhang, Kaixian Chen, Zhaoxiang Bian, Chengyuan Lin, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20140194498
    Abstract: A novel polyisoprenylated tetracyclic xanthone, named garciesculentone B, isolated from Garcinia esculenta Y. H. Li is disclosed in the present invention. This compound is shown to have significant cytotoxicity against various cancer cells. In addition, garciesculentone B is shown to have antimigration effect on various cancer cells such as human esophageal carcinoma cell. The experimental data supports that this compound is useful for developing into an anticancer drug.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Hong ZHANG, Zhichao XI, Hongsheng TAN, Kaixian CHEN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20140194499
    Abstract: Two novel polyprenylated benzoylphloroglucinol derivatives, garciesculentones A and C, are disclosed in the present invention. Garciesculentones A and C exhibit cytotoxicity and/or antimigration effect against various cancer cell lines. The experimental results of the present invention suggest that Garciesculentones A and C are useful for developing into anticancer drugs.
    Type: Application
    Filed: January 9, 2014
    Publication date: July 10, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Hong ZHANG, Yuanzhi LAO, Dandan ZHANG, Kaixian CHEN, Zhaoxiang BIAN, Chengyuan LIN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20140194528
    Abstract: The present invention relates to a synthetic compound and its therapeutic uses.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Yunhui SHEN, Yuanzhi LAO, Kaixian CHEN, Dajian YANG, Shilin CHEN, Zhaoxiang BIAN, Aiping LU, Albert Sun Chi CHAN, Chengyuan LIN
  • Publication number: 20140194529
    Abstract: This invention relates to the use of a compound from natural sources for therapeutic uses. More particularly, it relates to a compound, Garcimultiflorone E, naturally occurring in the plant of Garcinia esculenta Y. H. Li which has potent anti-inflammation and anti-cancer effect.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Dandan ZHANG, Hong ZHANG, Kaixian CHEN, Zhaoxiang BIAN, Chengyuan LIN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20140194530
    Abstract: Disclosed is a natural compound, Oblongifolin C, isolated from a natural plant comprising Garcinia species such as Garcinia yunnanesis Hu, for its effects of anti-migration and anti-invasion against cancer and its use as an anticancer drug. The treated cancers comprise cervical cancers and esophageal cancers. The cancer treatment comprises inhibition of cancer metastasis and inhibition of autophagic flux.
    Type: Application
    Filed: January 9, 2014
    Publication date: July 10, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi Xu, Yuanzhi Lao, Hongsheng Tan, Naihan Xu, Xiaoyu Wang, Zhenyan Liu, Kaixian Chen, Zhaoxiang Bian, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 8652540
    Abstract: The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and/or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 18, 2014
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Aiping Lu, Haitao Xiao, Hongyan Qin, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Publication number: 20130344174
    Abstract: The present invention discloses the utility of factions and compounds from Polygonum chinense Linn in anti-diarrhea. The invention also includes their preparation and application method for anti-diarrhea treatment.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 26, 2013
    Applicant: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang BIAN, Haitao XIAO, Shilin CHEN, Dajian YANG, Hongxi XU, Aiping LU, Albert Sun-Chi CHAN
  • Publication number: 20130323329
    Abstract: The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihyro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and/or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 5, 2013
    Applicant: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang BIAN, Siu Wai TSANG, Aiping LU, Haitao XIAO, Hongyan QIN, Albert Sun-Chi CHAN, Hongxi XU, Shilin CHEN, Dajian YANG
  • Publication number: 20060084615
    Abstract: The present invention provides acetylated derivatives of the compound puerarin that have enhanced bioavailability and are particularly suitable for oral administration. The present invention also teaches the use of medicaments containing acetylated derivatives of puerarin that are suitable for the treatment of myocardial ischemia and for modulating blood lipid levels, dilating coronary and cerebral arteries, reducing oxygen consumption of cardiomyocytes, improving microcirculation and preventing aggregation of blood platelets.
    Type: Application
    Filed: October 20, 2004
    Publication date: April 20, 2006
    Inventors: Albert Chan, Shi Chen, Yueming Li, Dajian Yang
  • Publication number: 20060045927
    Abstract: The present invention concerns herbal formulations for the modification of the levels of blood lipids. Aspects of the invention include the preparation of herbal formulations and methods for their use.
    Type: Application
    Filed: August 25, 2004
    Publication date: March 2, 2006
    Inventors: Dajian Yang, Meng Huang, Shi Chen, Albert Chan