Patents by Inventor Dajun KUANG
Dajun KUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11925552Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.Type: GrantFiled: September 30, 2022Date of Patent: March 12, 2024Assignee: VENUS MEDTECH (HANGZHOU), INC.Inventors: Dajun Kuang, Jesse Jun Qi, Min Frank Zeng, Jincheng Yu, Lo Pham, Lai Nguyen
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Publication number: 20230330300Abstract: A biological material is provided and prepared by performing (a) oxidation, (b) first cross-linking, (c) second cross-linking, and (d) dehydration on a biological material for preparation; wherein (b) is performed after (a), and (a), (b), and (c) are all performed prior to (d); during oxidation, an oxidizing agent able to cause hydroxy groups to be converted to aldehyde groups is utilized, the hydroxy groups coming from mucopolysaccharides in the biological material; during first cross-linking, a first cross-linking agent able to cause cross-linking between aldehyde groups of mucopolysaccharides is utilized; and during second cross-linking, a second cross-linking agent able to cause cross-linking between collagen fibers in the biological material is utilized.Type: ApplicationFiled: June 19, 2023Publication date: October 19, 2023Applicant: VENUS MEDTECH (HANGZHOU) INC.Inventors: Xing Wei, Hou-Sen Lim, Dajun Kuang
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Publication number: 20230330306Abstract: Provided are a pro-endothelialization biological material and method for preparation thereof, and a pro-endothelialization heart valve and method for preparation thereof and interventional system. The pro-endothelialization biological material comprises a biological material and a pro-endothelializing growth factor loaded on the surface of biological material; capable of capturing endothelial progenitor cells, enabling the endothelial progenitor cells to attach, grow, and differentiate on the surface of the biological material. The methods for preparation of the pro-endothelialization biological material comprises chemical grafting and physical coating methods. The heart valve can be prepared either by suturing followed by grafting or by grafting followed by suturing. A endothelial growth factor is directly loaded onto the surface of a biological material film, promoting the formation of endothelial cell layers on the surface of the biological material.Type: ApplicationFiled: June 19, 2023Publication date: October 19, 2023Applicant: VENUS MEDTECH (HANGZHOU) INC.Inventors: Zhaogang Liu, Yuting Zhu, Dajun Kuang, Hou-Sen Lim
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Publication number: 20230023378Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1 , 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.Type: ApplicationFiled: September 30, 2022Publication date: January 26, 2023Applicant: VENUS MEDTECH (HANGZHOU), INC.Inventors: Dajun Kuang, Jesse Jun Qi, Min Frank Zeng, Jincheng Yu, Lo Pham, Lai Nguyen
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Patent number: 11464630Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 10) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.Type: GrantFiled: March 3, 2020Date of Patent: October 11, 2022Assignee: Venus Medtech (Hangzhou) IncInventors: Dajun Kuang, Jesse Jun Qi, Min Frank Zeng, Jincheng Yu, Lo Pham, Lai Nguyen
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Publication number: 20210268151Abstract: A pre-loadable biological heart valve capable of rapid rehydration and a preparation method thereof. The preparation method comprises a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution; a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain a pre-loadable biological heart valve capable of rapid rehydration. The pre-loadable biological heart valve prepared by the preparation method of the present disclosure achieves rapid rehydration, and the crease can be quickly flattened after rehydration, bringing convenience during use.Type: ApplicationFiled: May 6, 2021Publication date: September 2, 2021Applicants: VENUS MEDTECH (HANGZHOU), INC., Sichuan UniversityInventors: Yunbing Wang, Gaocan Li, Yang Lei, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
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Publication number: 20210260247Abstract: A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.Type: ApplicationFiled: May 6, 2021Publication date: August 26, 2021Applicants: VENUS MEDTECH (HANGZHOU), INC., Sichuan UniversityInventors: Yunbing Wang, Yang Lei, Gaocan Li, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
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Publication number: 20200306035Abstract: A stent device having a skirt (2, 107) for peripheral leakage prevention and a processing method thereof, a skirt (2, 107) folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent (1, 105) to fit to the inner wall of a vessel more snugly, such that the stent (1, 105) does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.Type: ApplicationFiled: March 3, 2020Publication date: October 1, 2020Applicant: VENUS MEDTECH (HANGZHOU), INC.Inventors: Dajun Kuang, Jincheng Yu, Housen Lim
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Publication number: 20200289260Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.Type: ApplicationFiled: March 3, 2020Publication date: September 17, 2020Applicant: VENUS MEDTECH (HANGZHOU), INC.Inventors: Dajun Kuang, Jesse Jun Qi, Min Frank Zeng, Jincheng Yu, Lo Pham, Lai Nguyen
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Patent number: 10768099Abstract: An in-vitro biological valve calcification evaluation method, comprising the following steps: preparing calcification evaluation solution comprising glutaraldehyde solution, saline solution, borate buffer solution, reducing calcium ingredient solution and calcium-containing plasma solution, the reducing calcium ingredient solution comprising alcohol, alkaline solution, oil and its derivatives, and buffer solution; preheating the reducing calcium ingredient solution; conducting treatment with the glutaraldehyde solution prior to reducing calcium ingredient solution; conducting treatment with the reducing calcium ingredient solution; preserving the valve samples; conducting in-vitro calcification reaction with the calcium-containing plasma solution; and detecting calcium content by atomic absorption spectrum.Type: GrantFiled: January 22, 2018Date of Patent: September 8, 2020Assignee: VENUS MEDTECH (HANGZHOU) INC.Inventors: Nan Shao, Dajun Kuang
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Publication number: 20180149585Abstract: An in-vitro biological valve calcification evaluation method, comprising the following steps: preparing calcification evaluation solution comprising glutaraldehyde solution, saline solution, borate buffer solution, reducing calcium ingredient solution and calcium-containing plasma solution, the reducing calcium ingredient solution comprising alcohol, alkaline solution, oil and its derivatives, and buffer solution; preheating the reducing calcium ingredient solution; conducting treatment with the glutaraldehyde solution prior to reducing calcium ingredient solution; conducting treatment with the reducing calcium ingredient solution; preserving the valve samples; conducting in-vitro calcification reaction with the calcium-containing plasma solution; and detecting calcium content by atomic absorption spectrum.Type: ApplicationFiled: January 22, 2018Publication date: May 31, 2018Applicant: VENUS MEDTECH (HANGZHOU), INC.Inventors: Nan SHAO, Dajun KUANG