Patents by Inventor Dalam LY

Dalam LY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR EXPANSION OF DOUBLE NEGATIVE REGULATORY T CELLS
    Publication number: 20230128394
    Abstract: There is provided herein a method for expanding human CD4?CD8? regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR+CD56? or alternatively ??-TCR+.
    Type: Application
    Filed: December 23, 2022
    Publication date: April 27, 2023
    Applicant: UNIVERSITY HEALTH NETWORK
    Inventors: Li ZHANG, Paulina ACHITA, Jongbok LEE, Dalam LY, Dzana DERVOVIC
  • GENETICALLY ENGINEERED DOUBLE NEGATIVE T CELLS AS AN ADOPTIVE CELLULAR THERAPY
    Publication number: 20230011889
    Abstract: The disclosure relates to the development and use of CD4? CD8? double negative T (DNT) cells genetically modified to bind to one or more target antigens to enhance DNT cell anti-cancer activity such as with a chimeric antigen receptor (CAR). Genetically modified DNT cells can be generated ex vivo and expanded from allogeneic healthy donor cells and used as off-the-shelf therapy to overcome allogeneic graft-versus-host disease (GvHD) and/or host-versus-graft rejection in the treatment of cancer.
    Type: Application
    Filed: December 7, 2020
    Publication date: January 12, 2023
    Inventors: Li Zhang, Jong Bok Lee, Daniel Vasic, Ismat Khatri, Dalam Ly, Yuki Sze Long Leung
  • Method for expansion of double negative regulatory T cells
    Patent number: 11534460
    Abstract: There is provided herein a method for expanding human CD4-CD8- regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR-CD56- or alternatively ?8-TCR+.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 27, 2022
    Assignee: University Health Network
    Inventors: Li Zhang, Paulina Achita, Jong Lee, Dalam Ly, Dzana Dervovic
  • DOUBLE NEGATIVE T CELLS AND PD-1 BLOCKADE FOR THE TREATMENT OF CANCER
    Publication number: 20200046768
    Abstract: Methods for the treatment of cancer using double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor are described. Tumors treated with DNTs and a PD-1 inhibitor exhibited increased DNT cell infiltration and increased cytotoxicity towards non-small cell lung cancer (NSCLC) cells. Also described are compositions and kits comprising DNTs and a PD-1 or PD-L1 inhibitor and their use for the treatment of cancer.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 13, 2020
    Inventors: Li Zhang, Dalam Ly, Linan Fang
  • METHOD FOR EXPANSION OF DOUBLE NEGATIVE REGULATORY T CELLS
    Publication number: 20180104278
    Abstract: There is provided herein a method for expanding human CD4?CD8? regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), prefer-ably the DN Tregs are ??-TCR?CD56? or alternatively ??-TCR+.
    Type: Application
    Filed: May 11, 2016
    Publication date: April 19, 2018
    Inventors: Li ZHANG, Paulina ACHITA, Jong LEE, Dalam LY, Dzana DERVOVIC