Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.

Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.

Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.

Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.

Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.

Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

Abstract: The invention features pharmaceutically-active indolizines and tetrahydroindolizines that are each substituted with phenyl, methods of making them, and methods of using them.

Abstract: A pin for holding a rotary tiller tine hub in place on a shaft is, in turn, held in place by a wire clip having a straight intermediate section extending parallel to the shaft and received in a transverse hole extending through the pin adjacent an end thereof, the intermediate section extending perpendicular to and joining a straight end section and an arcuate section which embraces and extends about the hub.

Abstract: A combined mechanical and electrical control for the traction drive and collector-impeller drive of a snowblower is provided which operates to disconnect the traction drive when the operator loosens his grip on a traction drive control lever to an extreme drive-disengage position to which it is constantly biased. Further, the control operates to stop the engine in the event that the operator loosens his grip on the level when the collector-impeller drive is engaged. However, the control is arranged such that the operator may manually hold the traction drive control lever in an intermediate drive-disengage position, while leaving the collector-impeller drive engaged without the engine stopping.

Abstract: A drive chain trained about a drive and driven sprockets of different diameters is kept in proper tension by a tensioning device comprising a tensioning member located between the sprockets and extending transversely to the line of centers passing through the axes of rotation of the sprockets. The tensioning member is in the form of a rectangular block defining an opening through which the drive chain passes, opposite sides of the opening being bounded by inwardly facing abutment surfaces respectively engaging the opposite runs of the chain. The tensioning member is biased towards the larger of the sprockets and against the chain through means of a coil compression spring mounted on a guide rod which passes through an opening in the tensioning member and is pivotally mounted on and for swinging movement to the opposite sides of the line of centers of the sprockets at a location between the tensioning member and the smaller of the sprockets.