Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Abstract: A programmable network arranged for obtaining or providing legal services or advice includes brief storage for storing a brief of one or more legal service or advice seekers seeking a corresponding service or corresponding advice and legal service provider or advisor brief storage access arranged for enabling access by one or more legal service providers or advisors to the brief storage. The brief storage access is further arranged for selective access by each of the one or more legal service providers or advisors to each brief of the one or more legal service or advice seekers. A method of obtaining or providing legal services or advice includes storing a brief of one or more legal service or advice seekers seeking a corresponding service or corresponding advice and one or more legal service providers or advisors selectively accessing each brief.

Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.

Abstract: The present dislcosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV), methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of viral infections. The present dislcosure also provides methods for identifying amide-based, non-nucleoside compounds having antiviral activity.

Abstract: A conveying apparatus comprises an elongated conveying bed which includes a proximal end and a distal end. A support structure for the conveying bed accommodates vibratory motion of a portion of the conveying bed extending from the proximal end a substantial distance toward the distal end but dampens vibratory motion at the distal end. In addition, a piezoelectric driver is operatively connected to the conveying bed adjacent the proximal end. Consequently, operation of the piezoelectric driver will induce a wave motion in the conveying bed which will effectively convey a material from the proximal end to the distal end.

Abstract: A conveying apparatus comprises an elongated conveying bed which includes a proximal end and a distal end. A support structure for the conveying bed accommodates vibratory motion of a portion of the conveying bed extending from the proximal end a substantial distance toward the distal end but dampens vibratory motion at the distal end. In addition, a piezoelectric driver is operatively connected to the conveying bed adjacent the proximal end. Consequently, operation of the piezoelectric driver will induce a wave motion in the conveying bed which will effectively convey a material from the proximal end to the distal end.

Abstract: A conveying apparatus comprises an elongated conveying bed which includes a proximal end and a distal end. A support structure for the conveying bed accommodates vibratory motion of a portion of the conveying bed extending from the proximal end a substantial distance toward the distal end but dampens vibratory motion at the distal end. In addition, a piezoelectric driver is operatively connected to the conveying bed adjacent the proximal end. Consequently, operation of the piezoelectric driver will induce a wave motion in the conveying bed which will effectively convey a material from the proximal end to the distal end.

Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.

Abstract: A conveying apparatus comprises an elongated conveying bed which includes a proximal end and a distal end. A support structure for the conveying bed accommodates vibratory motion of a portion of the conveying bed extending from the proximal end a substantial distance toward the distal end but dampens vibratory motion at the distal end. In addition, a piezoelectric driver is operatively connected to the conveying bed adjacent the proximal end. Consequently, operation of the piezoelectric driver will induce a wave motion in the conveying bed which will effectively convey a material from the proximal end to the distal end.

Abstract: Disclosed herein are hepatitis C viral protease inhibitors of formula (I): wherein a is 0 or 1; b is 0 or 1; Y is H or C1-6 alkyl; B is H, an acyl derivative or a sulfonyl derivative; R6, when present, is C1-6 alkyl substituted with carboxyl; R5, when present, is C1-6 alkyl optionally substituted with carboxyl; R4 is C1-10 alkyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); R3 is C1-10 alkyl optionally substituted with carboxyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); R2 is CH2—R20, NH—R20, O—R20 or S—R20; wherein R20 is a saturated or unsaturated C3-7 cycloalkyl or C4-10 (alkyl cycloalkyl) being optionally mono-, di- or tri-substituted with R21, or R20 is a C6 or C10aryl, C7-16 aralkyl, Het or (lower alkyl)-Het, all optionally mono-, di- or tri-substituted with R21, wherein R21 is as defined herein; R1 is C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, all optionally substituted with halogen; and W is hydroxy or a N-substituted amino: or W taken together with t

Abstract: Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Abstract: An apparatus for spreading particles, such as seasoning, on both sides of products conveyed in a product stream includes first and second conveyors arranged at different elevations, and a particle dispensing device arranged above a vertical overlap between the two conveyors such that particles dispensed by the spreading device falls on the product stream on the first conveyor and the product stream on the second conveyor. A turning apparatus is arranged between an outlet of the first conveyor and an inlet of the second conveyor such that the product stream is turned over as it is being deposited from the first conveyor onto the second conveyor. The turning apparatus includes a discharge lip on the outlet of the first conveyor, and a curved turning wall arranged spaced from the discharge lip.

Abstract: An apparatus for spreading particles, such as seasoning, on both sides of products conveyed in a product stream includes first and second conveyors arranged at different elevations, and a particle dispensing device arranged above a vertical overlap between the two conveyors such that particles dispensed by the spreading device falls on the product stream on the first conveyor and the product stream on the second conveyor. A turning apparatus is arranged between an outlet of the first conveyor and an inlet of the second conveyor such that the product stream is turned over as it is being deposited from the first conveyor onto the second conveyor. The turning apparatus includes a discharge lip on the outlet of the first conveyor, and a curved turning wall arranged spaced from the discharge lip.

Abstract: A racemate, diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or B is an acyl derivative of formula R4—C(O)—; a carboxyl derivative of formula R4—O—C(O)—; an amide derivative of formula R4—N(R5)—C(O)—; a thioamide derivative of formula R4—N(R5)—C(S)—; or a sulfonyl of formula R4—SO2; R5 is H or C1-6 alkyl; and Y is H or C1-6 alkyl; R3 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl; R2 is CH2—R20, NH—R20, O—R20 or S—R20, wherein R20 is a satu

Abstract: A cooling system particularly but not exclusively for cooling milk transferred for a milking station to a vat along a first flow path, the system including an apparatus for heat exchange with milk passing therethrough, wherein a second flow path is provided for circulating milk in the vat through the apparatus and the second flow path isolated from the first flow path.