Patents by Inventor Dale E. Johnson

Dale E. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 8309084
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: November 13, 2012
    Assignee: Abbott Biotherapeutics Corp.
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS
    Publication number: 20110300133
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Application
    Filed: January 19, 2011
    Publication date: December 8, 2011
    Applicant: Abbott Biotherapeutics Corp.
    Inventors: Vanitha RAMAKRISHNAN, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 8017116
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: September 13, 2011
    Assignee: Abbott Biotherapeutics Corp.
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 7897148
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: March 1, 2011
    Assignee: Abbott Biotherapeutics Corp.
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 7879987
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: February 1, 2011
    Assignee: Facet Biotech Corporation
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 7776585
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: August 17, 2010
    Assignee: Facet Biotech Corporation
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Novel Methods and Devices for Evaluating Poisons
    Publication number: 20100179765
    Abstract: Methods and devices useful for evaluating poisons or other chemical entities, and for using such methods to forecast unfavorable drug effects.
    Type: Application
    Filed: October 2, 2009
    Publication date: July 15, 2010
    Inventors: Edwin P. Ching, Dale E. Johnson, Sucha Sudarsanam
  • CHIMERIC AND HUMANIZED ANTIBODIES TO alpha5beta1 INTEGRIN THAT MODULATE ANGIOGENESIS
    Publication number: 20090259031
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Application
    Filed: August 17, 2007
    Publication date: October 15, 2009
    Inventors: VANITHA RAMAKRISHNAN, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • USE OF ANTI-INTEGRIN ANTIBODIES FOR REDUCING SCAR TISSUE FORMATION
    Publication number: 20090041785
    Abstract: The present invention provides methods that enable the user to identify inhibitors of tissue granulation in and around a wound site, thereby limiting excessive scar formation as the wounded tissue heals. The some granulation inhibitors identified using the methods of the invention inhibit granulation in and around a wound site up to five fold, with a corresponding decrease in the formation of scar tissue when tested on retinal injuries. Granulation inhibitors that can be identified using the methods of the present invention include antibodies, peptides, nucleic acids (aptamers), and non-peptide small molecules.
    Type: Application
    Filed: September 19, 2008
    Publication date: February 12, 2009
    Inventors: Dale E. Johnson, Ursula Jeffry
  • CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS
    Publication number: 20080260732
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Application
    Filed: September 7, 2007
    Publication date: October 23, 2008
    Inventors: VANITHA RAMAKRISHNAN, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 7285268
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: October 23, 2007
    Assignee: PDL Biopharma, Inc.
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry
  • Chimeric and humanized antibodies to ?5?1 integrin that modulate angiogenesis
    Patent number: 7276589
    Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: October 2, 2007
    Assignee: PDL Biopharma, Inc.
    Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
  • Support shaft apparatus
    Patent number: 3941328
    Abstract: A rotating member, such as a roll of paper is supported by a pair of shafts extending into opposite ends of an axial bore in the rotating member. The shafts, which have rubber bushings which expand outwardly into tight fit within the axial bore, are constructed to enable ready removal of the shafts from the roll, for example, to change the roll.
    Type: Grant
    Filed: April 15, 1975
    Date of Patent: March 2, 1976
    Inventor: Dale E. Johnson