Patents by Inventor Dale E. Robinson, Jr.

Dale E. Robinson, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLIDINYL GROUPS FOR ATTACHING CONJUGATES TO OLIGOMERIC COMPOUNDS
    Publication number: 20090203132
    Abstract: The present invention provides pyrrolidinyl compounds that are useful for preparing conjugated oligomeric compounds. The conjugated pyrrolidinyl compounds can be attached to support medium and provide a free hydroxyl for oligomer synthesis to prepare an oligmeric compound having a 3?-conjugate. Alternatively, the pyrrolidinyl compound can be prepared as a phosphoramidite which can be placed internally or at the 5?-position of an oligomeric compound. These two strategies can be used together to prepare oligomeric compounds having 2 or more conjugates at any selected positions. The present invention also provides methods for modulating gene expression using the conjugated oligomeric compounds.
    Type: Application
    Filed: September 1, 2005
    Publication date: August 13, 2009
    Inventors: Eric E. Swayze, Dale E. Robinson, JR., Elizabeth Anne Jefferson, Prasad Dande, Thazha P. Prakash, Charles Allerson, Balkrishen Bhat
  • Antimicrobial biaryl compounds
    Patent number: 7432264
    Abstract: Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: October 7, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Elizabeth Anne Jefferson, Eric E. Swayze, Punit P. Seth, Dale E. Robinson, Jr.