Patents by Inventor Dale G. McLeod

Dale G. McLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Penem prodrugs
    Patent number: 7795243
    Abstract: Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 14, 2010
    Assignee: Pfizer, Inc.
    Inventors: Katherine E. Brighty, Anthony Marfat, Dale G. McLeod, John P. O'Donnell
  • PENEM PRODRUGS
    Publication number: 20090042853
    Abstract: Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof preparation thereof formulation thereof and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.
    Type: Application
    Filed: June 30, 2008
    Publication date: February 12, 2009
    Inventors: Katherine E. BRIGHTY, Anthony Marfat, Dale G. Mcleod, John P. O'Donnell
  • PENEM PRODRUGS
    Publication number: 20080009474
    Abstract: Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 10, 2008
    Inventors: Katherine E. BRIGHTY, Anthony Marfat, Dale G. McLeod, John P. O'Donnell
  • Beta-lactamase inhibitor prodrug
    Patent number: 7091197
    Abstract: Prodrugs of 6-?-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention or a solvate thereof, an optional beta-lactam antibiotic and a pharmaceutically acceptable excipient. Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof. Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: August 15, 2006
    Assignee: Pfizer Inc.
    Inventors: Anthony Marfat, Dale G. McLeod
  • Nicotinamide derivatives useful as PDE4 inhibitors
    Patent number: 7060717
    Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: June 13, 2006
    Assignee: Pfizer Inc
    Inventors: Simon Bailey, Elisabeth C. L. Gautier, Alan J. Henderson, Thomas V. Magee, Anthony Marfat, John P. Mathias, Dale G. McLeod, Sandra M. Monaghan, Blanda L. C. Stammen
  • Nicotinamide derivatives useful as PDE4 inhibitors
    Patent number: 6949573
    Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: September 27, 2005
    Assignee: Pfizer Inc
    Inventors: Simon Bailey, Elisabeth C. L. Gautier, Alan J. Henderson, Thomas V. Magee, Anthony Marfat, John P. Mathias, Dale G. McLeod, Sandra M. Monaghan, Blanda L. C. Stammen
  • Nicotinamide derivatives useful as PDE4 inhibitors
    Publication number: 20040224975
    Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
    Type: Application
    Filed: June 9, 2004
    Publication date: November 11, 2004
    Applicant: Pfizer Inc.
    Inventors: Simon Balley, Elisabeth C. L. Gautier, Alan J. Henderson, Thomas V. Magee, Anthony Marfat, John P. Mathias, Dale G. McLeod, Sandra M. Monaghan, Blanda L. C. Stammen
  • Beta-lactamase inhibitor prodrug
    Publication number: 20040110740
    Abstract: Prodrugs of 6-&bgr;-hydroxymethylpenicillanic acid sulfone having the structure 1
    Type: Application
    Filed: August 25, 2003
    Publication date: June 10, 2004
    Applicant: Pfizer Inc
    Inventors: Anthony Marfat, Dale G. McLeod
  • Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
    Publication number: 20030220361
    Abstract: The invention relates to a combination of a nicotinamide derivative and tiotropium or a derivative thereof, compositions containing it and the uses of, such a combination. The combination according to the present invention is useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
    Type: Application
    Filed: February 6, 2003
    Publication date: November 27, 2003
    Inventors: Simon Bailey, Elisabeth C. L. Gautier, Alan J. Henderson, Thomas V. Magee, Anthony Marfat, John P. Mathias, Dale G. McLeod, Sandra M. Monaghan, Blanda L. C. Stammen
  • Nicotinamide derivatives useful as PDE4 inhibitors
    Publication number: 20030220366
    Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
    Type: Application
    Filed: February 6, 2003
    Publication date: November 27, 2003
    Inventors: Simon Bailey, Elisabeth C. L. Gautier, Alan J. Henderson, Thomas V. Magee, Anthony Marfat, John P. Mathias, Dale G. McLeod, Sandra M. Monaghan, Blanda L. C. Stammen