Abstract: Methods for treating a proliferative disease or disorder by administering an antibody radio-conjugate alone or in combination with an immune checkpoint therapy such as an antibody against an immune checkpoint inhibitor, and/or a DNA damage response inhibitor. The proliferative disease or disorder may be a solid cancer, such as breast cancer, ovarian cancer, or prostate cancer.

Abstract: The disclosure provides humanized 3E10 antibodies and antigen binding fragments thereof. Compositions and methods of using the humanized 3E10 antibodies and antigen binding fragments thereof to deliver cargo are also disclosed.

Abstract: The present application includes methods, apparatuses, and systems for cleaning an aluminum wheel. In particular instances, a method of treating an exterior surface of an aluminum vehicle wheel comprising: blasting the exterior surface a first occurrence for a first duration at a first velocity using blasting media; blasting the exterior surface a second occurrence for a second duration at a second velocity using blasting media after blasting the exterior surface for a first duration, the second velocity being substantially lower than the first velocity; and, arranging the vehicle wheel in contact with vibratory finishing media and vibrating the vehicle wheel with the vibratory finishing media for a duration after blasting the exterior surface in each of the first and second occurrences.

Abstract: Compositions and methods useful for the treatment of hemoglobinopathies and hematological diseases are disclosed herein. The compositions include an actinium-225 labeled anti-CD45 antibody (BC8) formulated as a single patient dose that is wholly deliverable to a patient in a single dose. The actinium-225 labeled anti-CD45 may be administered alone or in combination with additional therapeutic agents, such as other immunotherapeutics or a radiosensitizing agent, or additional therapeutic interventions, such as bone marrow transplant or adoptive cell therapies.

Abstract: Compositions and methods for transient immunodepletion of specific subsets of a subject's immune cells are disclosed. The methods generally include administering to the subject an effective amount of a radiolabeled antibody against CD19, CD20, CD33, CD38, CD45RA, CD52, or a combination thereof. The effective amount of the radiolabeled antibody depletes at least 50% of the targeted immune cells, and less than 20% of the subject's stem cells. When used alone, these methods may target lymphomas, leukemias, and myelomas, and/or may additionally allow repopulation of non-autoreactive immune cells in patients with an autoimmune disease. When these methods precede certain cell-based therapies, such as adoptive cell therapy and/or hematopoietic stem cell therapy, the methods are able to enhance the outcome of the cell-based therapies while minimizing adverse effects.

Abstract: This invention provides a compositions of matter comprising a therapeutic protein population (such as a HuM195 antibody population) wherein (a) each therapeutic protein in the population is conjugated to one or more actinium atoms, (b) each actinium atom is either 227Ac or 225Ac, and (c) the molar ratio of 227Ac to 225Ac in the composition is at least 1:1, This invention also provides related synthetic compositions and methods, as well as methods for treating hematologic malignancies.

Abstract: This invention provides a method for treating a subject afflicted with cancer, comprising administering to the subject (i) a PARP inhibitor in conjunction with (ii) a radioisotope-labeled agent that targets cancer cells in the subject, wherein the amounts of the PARP inhibitor and labeled agent, when administered in conjunction with one another, are therapeutically effective. This invention also provides a method for inducing the death of a cancer cell, comprising contacting the cell with (i) a PARP inhibitor in conjunction with (ii) a radioisotope-labeled agent that targets the cancer cell, wherein the amounts of PARP inhibitor and labeled agent, when concurrently contacted with the cell, are effective to induce the cell's death.

Abstract: Particular embodiments of the invention comprises a composition for reducing weight imbalances, force variations, and/or vibrations in a tire-wheel assembly, the composition comprising a first plurality of particulate for positioning within the tire-wheel assembly, where each particle in the first plurality of particulate is characterized as having low energy absorption capabilities, and a second plurality of particulate for positioning within the tire-wheel assembly, where each particle in the second plurality of particulate is characterized as having elevated energy absorption capabilities. Additional embodiments of the invention comprise a method for reducing force imbalances, force variations, and/or vibrations in a tire-wheel assembly, which includes the steps of providing a tire-wheel assembly and placing into a pressurization chamber of said tire-wheel assembly a composition as contemplated in any embodiment or combination of embodiments suggested herein.

Abstract: Methods for treating a proliferative disease or disorder by administering a radioimmunotherapy to generate an immune response in combination with immune checkpoint therapy to further enhance the immune response.

Abstract: Particular embodiments of the invention comprises a composition for reducing weight imbalances, force variations, and/or vibrations in a tire-wheel assembly, the composition comprising a first plurality of particulate for positioning within the tire-wheel assembly, where each particle in the first plurality of particulate is characterized as having low energy absorption capabilities, and a second plurality of particulate for positioning within the tire-wheel assembly, where each particle in the second plurality of particulate is characterized as having elevated energy absorption capabilities. Additional embodiments of the invention comprise a method for reducing force imbalances, force variations, and/or vibrations in a tire-wheel assembly, which includes the steps of providing a tire-wheel assembly and placing into a pressurization chamber of said tire-wheel assembly a composition as contemplated in any embodiment or combination of embodiments suggested herein.

Abstract: Particular embodiments of the invention comprises a composition for reducing weight imbalances, force variations, and/or vibrations in a tire-wheel assembly, the composition comprising a first plurality of particulate for positioning within the tire-wheel assembly, where each particle in the first plurality of particulate is characterized as having low energy absorption capabilities, and a second plurality of particulate for positioning within the tire-wheel assembly, where each particle in the second plurality of particulate is characterized as having elevated energy absorption capabilities. Additional embodiments of the invention comprise a method for reducing force imbalances, force variations, and/or vibrations in a tire-wheel assembly, which includes the steps of providing a tire-wheel assembly and placing into a pressurization chamber of said tire-wheel assembly a composition as contemplated in any embodiment or combination of embodiments suggested herein.

Abstract: A substantially purified nucleic acid molecule comprising a VDUP1 promoter region, capable of directing expression of a polypeptide encoding sequence to which it is operably linked, whose expression is induced to maximal levels as a result of prolonged cell culture.