Patents by Inventor Dale M. Walker

Dale M. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IMPROVED DELIVERY OF AMINOTHIOLS, DIMERS OF AMINOTHIOLS, AND HETERODIMERS COMPOSED OF AMINOTHIOLS
    Publication number: 20240131165
    Abstract: The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.
    Type: Application
    Filed: December 21, 2023
    Publication date: April 25, 2024
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • METHODS FOR IMPROVED PROTECTION AND DELIVERY OF AMINOTHIOLS AND ANALOGS THEREOF
    Publication number: 20230364246
    Abstract: In one aspect, the present application relates to an aminothiol-conjugate of formula (I): wherein R1, R2, R3, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).
    Type: Application
    Filed: December 13, 2022
    Publication date: November 16, 2023
    Inventors: Dale M. WALKER, Vernon E. WALKER, Tsvetelina I. LAZAROVA, Steven W. RIESINGER
  • BROAD SPECTRUM ANTIVIRAL AND METHODS OF USE
    Publication number: 20230277566
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: October 4, 2022
    Publication date: September 7, 2023
    Inventors: Dale M. WALKER, Adriana Elisa KAJON, Vernon E. WALKER
  • Methods for improved protection and delivery of aminothiols and analogs thereof
    Patent number: 11554174
    Abstract: In one aspect, the present application relates to an aminothiol-conjugate of formula (I): wherein , , R1, R2, R3, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: January 17, 2023
    Assignee: THE BURLINGTON HC RESEARCH GROUP, INC.
    Inventors: Dale M. Walker, Vernon E. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger
  • METHODS FOR IMPROVED DELIVERY OF AMINOTHIOLS, DIMERS OF AMINOTHIOLS, AND HETERODIMERS COMPOSED OF AMINOTHIOLS
    Publication number: 20220273802
    Abstract: The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.
    Type: Application
    Filed: January 13, 2022
    Publication date: September 1, 2022
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • Broad Spectrum Antiviral and Methods of Use
    Publication number: 20210228601
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: September 2, 2020
    Publication date: July 29, 2021
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • METHODS FOR IMPROVED PROTECTION AND DELIVERY OF AMINOTHIOLS AND ANALOGS THEREOF
    Publication number: 20210023229
    Abstract: In one aspect, the present application relates to an aminothiol-conjugate of formula (I): wherein , , R1, R2, R3, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).
    Type: Application
    Filed: August 7, 2020
    Publication date: January 28, 2021
    Inventors: Dale M. WALKER, Vernon E. WALKER, Tsvetelina I. LAZAROVA, Steven W. RIESINGER
  • Methods for improved protection and delivery of aminothiols and analogs thereof
    Patent number: 10780176
    Abstract: In one aspect, the present application relates to an aminothiol-conjugate of formula (I), wherein Core Linker R1, R2, R3, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 22, 2020
    Assignee: THE BURLINGTON HC RESEARCH GROUP, INC.
    Inventors: Dale M. Walker, Vernon E. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger
  • Broad Spectrum Antiviral and Methods of Use
    Publication number: 20200093841
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: April 30, 2019
    Publication date: March 26, 2020
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • METHODS FOR IMPROVED DELIVERY OF AMINOTHIOLS, DIMERS OF AMINOTHIOLS, AND HETERODIMERS COMPOSED OF AMINOTHIOLS
    Publication number: 20190083630
    Abstract: The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • METHODS FOR IMPROVED PROTECTION AND DELIVERY OF AMINOTHIOLS AND ANALOGS THEREOF
    Publication number: 20180369398
    Abstract: In one aspect, the present application relates to an aminothiol-conjugate of formula (I), wherein Core Linker R1, R2, R3, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).
    Type: Application
    Filed: November 17, 2016
    Publication date: December 27, 2018
    Inventors: Dale M. WALKER, Vernon E. WALKER, Tsvetelina I. LAZAROVA, Steven W. RIESINGER
  • Broad Spectrum Antiviral and Methods of Use
    Publication number: 20180344751
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: December 26, 2017
    Publication date: December 6, 2018
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • Broad spectrum antiviral and methods of use
    Patent number: 9849143
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 26, 2017
    Assignee: The Burlington HC Research Group, Inc.
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • Broad Spectrum Antiviral and Methods of Use
    Publication number: 20170157151
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • Broad spectrum antiviral and methods of use
    Patent number: 9585849
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: March 7, 2017
    Assignee: The Burlington HC Research Group, Inc.
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
  • Methods for Improved Delivery of Aminothiols, Dimers of Aminothiols, and Heterodimers Composed of Aminothiols
    Publication number: 20170028071
    Abstract: The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • ORGANIC THIOPHOSPHATE ANTIRETROVIRAL AGENTS
    Publication number: 20160374967
    Abstract: A method for the prevention or treatment of human immunodeficiency virus infection by administering an effective amount of amifostine, phosphonol, or similar compound to an individual in need is provided.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 29, 2016
    Inventors: Dale M. Walker, Vernon E. Walker, Miriam C. Poirier, Gene M. Shearer
  • Methods for Improved Delivery of Aminothiols, Dimers of Aminothiols, and Heterodimers Composed of Aminothiols
    Publication number: 20130337046
    Abstract: The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.
    Type: Application
    Filed: June 14, 2013
    Publication date: December 19, 2013
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • Detection and Quantification of Cellular Stress Response Resolution Pathway Expression and Functionality and the Effects of Agents or Conditions Thereupon
    Publication number: 20130040291
    Abstract: The assessment methods disclosed herein involve exposing cells to two stresses. The first stress (analogous to existing direct screening methods) involves exposing metazoan cells to an external stimulus of interest, such as exposing human cells to ionizing radiation, a chemical, or a set of physical conditions. The cells exposed to the first stress are thereafter exposed to a second stress which, importantly, is calibrated such that non-stressed cells of the same type will exhibit a predictable response to the second stress. By comparing the response to the second stress of i) cells that were exposed to the first stress and ii) cells that were not exposed to the first stress, an observer can assess whether exposure to the first stress caused or induced any change to the cells that affected the cells' ability to respond to the second stress.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 14, 2013
    Inventors: Dale M. WALKER, Vernon E. WALKER
  • Broad Spectrum Antiviral and Methods of Use
    Publication number: 20110053894
    Abstract: A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
    Type: Application
    Filed: April 17, 2007
    Publication date: March 3, 2011
    Applicant: LOVELACE RESPIRATORY RESEARCH INSTITUTE
    Inventors: Dale M. Walker, Adriana Elisa Kajon, Vernon E. Walker