Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: The invention is directed to an embodiment of the present invention is directed to an oil soluble additive composition prepared by a process comprising: reacting, (a) a molybdenum component; (b) an imide derived from the reaction product of a hydrocarbyl dicarboxylic acid component and a polyamine wherein said reaction product is prepared by first charging a polyamine to a reaction vessel and then charging a hydrocarbyl dicarboxylic acid component to the reaction vessel, wherein the charge mole ratio of the hydrocarbyl dicarboxylic acid component to the polyamine is from about 1:1 to about 1:0.5; and (c) a post-treating agent, thereby producing a post-treated moblydated succinimide additive composition.

Abstract: The present invention is directed to Mannich condensation product sequestering agents or mixtures of Mannich condensation product sequestering agents for use in fuels and lubricating oils. The present invention is also directed to a process for preparing the Mannich condensation product sequestering agents. The present invention is also directed to a product formed by combining, under reaction conditions, a polyisobutyl-substituted hydroxyaromatic compound, an aldehyde, an amino acid or ester thereof, and an alkali metal base to form the Mannich condensation product sequestering agent. The present invention is also directed to a lubricating oil composition, a lubricating oil concentrate, a fuel composition, and a fuel concentrate having the Mannich condensation product sequestering agents of the present invention.

Abstract: The invention is directed to an oil soluble additive composition prepared by a process comprising reacting a molybdenum component; an imide derived from the reaction product of a hydrocarbyl dicarboxylic acid component and a polyamine component wherein the hydrocarbyl dicarboxylic acid component is the reaction product of a dicarboxylic acid component and a hydrocarbyl component; and a post-treating agent, thereby producing a post-treated molybdated succinimide additive composition.

Abstract: Disclosed is a product prepared by the process for preparing a molybdated succinimide complex, the process comprising: (a) reacting an alkyl or alkenyl succinimide of a polyamine of formula I or formula II or mixtures thereof: wherein R is an about C12 to C30 alkyl or alkenyl group, R? is a straight or branched-chain alkylene group having 2 to 3 carbon atoms, x is 1 to 11, and y is 1 to 10, with an ?,?-unsaturated mono-carboxylic acid or carboxylic acid ester, in a charge mole ratio of the ?,?-unsaturated mono-carboxylic acid or carboxylic acid ester to the succinimide of formula I or formula II or mixtures thereof of about 0.1:1 to about 6:1, and wherein the reaction temperature is no greater than about 135° C.; and (b) reacting the succinimide product of step (a) with an acidic molybdenum compound to provide the molybdated succinimide complex, wherein the molybdated succinimide complex prepared is a liquid at room temperature.

Abstract: A buffer circuit includes an input stage including at least one MOS device having a first threshold voltage associated therewith, the input stage being adapted to receive an input signal referenced to a first voltage supply. The buffer circuit further includes an output stage including at least one MOS transistor having the first threshold voltage associated therewith, an input of the output stage being connected to an output of the input stage, the output stage being operative to generate an output signal which is indicative of a logic state of the input signal. The buffer circuit includes a delay control circuit adapted for connection between at least one of the first voltage supply and a voltage return of the buffer circuit, and at least one of the input stage and the output stage. The delay control circuit includes at least one MOS device having a second threshold voltage associated therewith.

Abstract: An exemplary embodiment providing one or more improvements includes removable faces for jaws in machine vise which are able to grip a work-piece with great stability, accuracy, and reproducibility. Embodiments include multiple gripping features so the gripping surface easily can be renewed by demounting and reversing a worn face to a new face. Embodiments include the ability to of the claw jaws to be mounted on any fixed or moveable vise station to use the entire clamping range of the machine vise. Embodiments are disclosed which are used with round or curved as well as flat work-pieces. Embodiments also include flat surfaced claw jaws which may be used to grip a work-piece for secondary machining to remove indentations from the work-piece.

Abstract: An exemplary embodiment providing one or more improvements includes removable faces for jaws in machine vise which are able to grip a work-piece with great stability, accuracy, and reproducibility. Embodiments include multiple gripping features so the gripping surface easily can be renewed by demounting and reversing a worn face to a new face. Embodiments include the ability to of the claw jaws to be mounted on any fixed or movable vise station to use the entire clamping range of the machine vise. Embodiments are disclosed which are used with round or curved as well as flat work-pieces. Embodiments also include flat surfaced claw jaws which may be used to grip a work-piece for secondary machining to remove indentations from the work-piece.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: A distal protection device for use in a body lumen. The device includes a functional element which may be a filter or an occlusive element. The device includes means for controlling the movement and placement of the functional element along a guidewire. Motion of the guidewire can be independent of the motion of the functional element.

Abstract: A multifunctional product is prepared by the reaction of an alkyl or alkenyl succinic acid derivative with a Fused-Ring Aromatic diamine, with a charge mole ratio of the diamine moiety in stoichiometric excess, under reactive conditions to thereby yield a multifunctional lubricant additive.

Abstract: A diagnostic control methodology provides reduced disruption of device operation when performing diagnostics on devices within a computer system. A diagnostic application notifies a device driver that controls a particular device that diagnostics should be performed during a period of low activity on the device. In response to receiving the notification, the device driver waits for a time of low activity and either notifies the application to unload the device driver and load a diagnostic device driver, or enters a diagnostic mode directly if such operation is supported by the functional device driver. A timeout duration can be specified, and may be set by the notification, so that the diagnostics will be performed within the timeout period even if a time of low activity has not occurred by the expiration of the timeout.

Abstract: A distal protection device for use in a body lumen. The device includes a functional element which may be a filter or an occlusive element. The device includes means for controlling the movement and placement of the functional element along a guidewire. Motion of the guidewire can be independent of the motion of the functional element.

Abstract: The invention provides an improved method for creating a formulation using a solid chemical agent in solution within a reservoir, and treating crops within a storage facility with an aerosol of the solution substantially at the time of use. The method includes having a premixing section for formulating the solution and mixing solid with a solvent in a premixing section. Further the solution may be heated by circulating it through a substantially instantaneous heater then channeling the solution into a commercial fogger, generating an aerosol of the CIPC solution, and providing said storage facility with said aerosol.

Abstract: A computer implemented method, apparatus, and computer program product for displaying information within a browser. Server browser information is stored on a web server. The server browser information includes a set of first category categories and a set of second category categories. An indication of whether a user is on a public system or a private system is received by the web server. Responsive to receiving the indication that the user is on a public system, only the set of public categories of the browser information is displayed to the user.

Abstract: A diagnostic control methodology provides reduced disruption of device operation when performing diagnostics on devices within a computer system. A diagnostic application notifies a device driver that controls a particular device that diagnostics should be performed during a period of low activity on the device. In response to receiving the notification, the device driver waits for a time of low activity and either notifies the application to unload the device driver and load a diagnostic device driver, or enters a diagnostic mode directly if such operation is supported by the functional device driver. A timeout duration can be specified, and may be set by the notification, so that the diagnostics will be performed within the timeout period even if a time of low activity has not occurred by the expiration of the timeout.

Abstract: An exemplary embodiment providing one or more improvements includes removable faces for jaws in machine vise which are able to grip a work-piece with great stability, accuracy, and reproducibility. Embodiments include multiple gripping features so the gripping surface easily can be renewed by demounting and reversing a worn face to a new face. Embodiments include the ability to of the claw jaws to be mounted on any fixed or movable vise station to use the entire clamping range of the machine vise. Embodiments are disclosed which are used with round or curved as well as flat work-pieces. Embodiments also include flat surfaced claw jaws which may be used to grip a work-piece for secondary machining to remove indentations from the work-piece.

Abstract: A catheter securement device which automatically deploys one or more sutures to secure a catheter without requiring the practitioner to manually suture the catheter to the self-suturing anchor device. A ratchet mechanism having one or more rotatable ratchet members, which pivot, and a ratchet member engagement spring, which maintains contact between the teeth of the rotatable ratchet member and the teeth of the ratchet ring. A suture retention assembly is provided to maintain the position of the sutures to minimize disruption of the sutures before deployment of the sutures.

Abstract: A computer implemented method, apparatus, and computer program product for displaying information within a browser. Server browser information is stored on a web server. The server browser information includes a set of first category categories and a set of second category categories. An indication of whether a user is on a public system or a private system is received by the web server. Responsive to receiving the indication that the user is on a public system, only the set of public categories of the browser information is displayed to the user.