Abstract: Medical devices, e.g., baffle devices, and related methods of use to administer therapeutic compositions to the eye are described. The medical device may include a body defining a lumen and including an intermediate portion that includes a compressible bellows. The device may have a flared distal end configured to contact a convex surface of the eye.

Abstract: The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

Abstract: Methods of treating eyes are described. The method may include administering an agent capable of disrupting corneal cell junctures to a corneal surface of the eye, the corneal surface comprising an intact epithelium and stroma; and administering riboflavin to the corneal surface after or simultaneously with the agent. The riboflavin may diffuse through the eye to penetrate the stroma within 10 minutes of administration of the riboflavin.

Abstract: Provided herein is injectable and/or sprayable, in situ polymerizable collagen-based compositions for sustained delivery of therapeutics (active agents, such as drugs, proteins, and other therapeutic agents). The compositions comprise (i) a neutral collagen solution, which is injectable or sprayable and capable of converting into a fibrous collagen mass or gel upon contacting with a physiological fluid or solution, or water; and (ii) a biologically or pharmaceutically active agent in the neutral collagen solution. The compositions are in the form of clear, transparent viscous solutions that instantaneously undergo gelation and polymerization when contacted by physiological fluids or solutions or water. The collagen solutions can be manipulated to provide various rates of sustained delivery of therapeutics.

Abstract: Medical devices, e.g., baffle devices, and related methods of use to administer therapeutic compositions to the eye are described. The medical device may include a body defining a lumen and including an intermediate portion that includes a compressible bellows. The device may have a flared distal end configured to contact a convex surface of the eye.

Abstract: Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Abstract: Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Abstract: The present invention is directed to collagen-hyaluronic acid based constructs for sustained delivery of agents and drugs to ocular tissues. In certain configurations, the constructs are prepared by a method comprising combining a derivatized collagen with a hyaluronic acid. In other configurations, the constructs are prepared by a method comprising combining a hyaluronic acid-poly-L-lysine (PLL) polymer with the derivatized collagen.

Abstract: Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Abstract: The present disclosure describes a composition for cartilage defects or deficiencies repair, augmentation or treatment comprising an injectable, in situ polymerizable collagen composition and chondrocytes or stem cells in the collagen composition. The present disclosure also relates to methods for repairing or augmenting or treating cartilage defects or deficiencies using the composition and the preparation method of the composition.

Abstract: Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Abstract: The present invention describes neutral pH soluble collagen-glycosaminoglycan compositions and methods for augmenting soft tissue defects using the compositions. Soft tissue defects include dermal wrinkles and dermal folds, dermal contour unevenness and laxity and subdermal volume deficiencies. The compositions may also be used for and promoting cellular growth and stimulating tissue regeneration.

Abstract: The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

Abstract: The present disclosure describes a composition for cartilage defects or deficiencies repair, augmentation or treatment comprising an injectable, in situ polymerizable collagen composition and chondrocytes or stem cells in the collagen composition. The present disclosure also relates to methods for repairing or augmenting or treating cartilage defects or deficiencies using the composition and the preparation method of the composition.

Abstract: Proived herein are derivatized or rapidly polymerizing collagen compositions for tissue augmentation containing non-resorbable or slowly resorbable polymers. Also provided are methods for the preparation of the compositions, and methods for augmenting soft tissue utilizing the compositions.

Abstract: Provided herein are hyaluronic acid compositions comprising hyaluronic acid or modified hyaluronic acid or crosslinked hyaluronic acid and slowly resorbable particles, spheres and granules. Also provided are methods for augmenting soft tissue utilizing the compositions.

Abstract: Embodiments of the present invention are directed to devices and apparatus for administering collagen modifier compounds to the dermis of skin.

Abstract: Medical devices and methods of treating subjects using such medical devices are described. The medical device may include a housing with at least two chambers including a first chamber adjacent to a second chamber; a barrier between the first chamber and the second chamber; and a soft, flexible base. The first and second chambers may be airtight, the barrier configured to establish fluid communication between the first chamber and the second chamber upon an application of force to the barrier.

Abstract: The present invention is directed to injectable acid soluble collagen compositions comprising a neutralized solution of an acid soluble collagen, EDTA and preferably a polyol, wherein the composition is injectable at physiological pH and the acid soluble collagen polymerizes upon exposure to tissue. The invention is suitable for use in soft tissue augmentation, promoting soft tissue regeneration and coating medical implants and devices.

Abstract: Compositions of proteoglycans and core proteins thereof and related methods of treating subjects, e.g., patients, are described. The method may include applying a composition to an eye of a subject before, during, and/or after an intraocular medical procedure. The composition may comprise a proteoglycan or core protein thereof, such as decorin proteoglycan or decorin core protein, and a pharmaceutically-acceptable salt. The composition may be in the form of an aqueous solution, viscoelastic gel, or viscoelastic film, for example. Further methods are described that include treating donor corneal tissue with a composition comprising a proteoglycan or core protein thereof. The treated donor corneal tissue may be used as or in a corneal graft, such as during endothelial keratoplasty.