Abstract: The present invention relates to methods of preparing pharmaceutical products, involving filling active pharmaceutical ingredient powders into pharmaceutical carriers with a vacuum assisted metering and filling device. The methods disclosed herein can be used in a continuous process, such as in a high-throughput process for producing a pharmaceutical product. The present invention further relates to a particular quality of the neat active pharmaceutical ingredient (API) HDM201, i.e. siremadlin, present as succinic acid co-crystal, which can be used in the methods of preparation of the present invention.

Abstract: An apparatus for filling a receptacle with a powder comprises a hopper adapted to contain a powder pharmaceutical formulation, the hopper comprising an outlet. A vibratable member is positioned in, on, or near the hopper so that the vibratable member is spaced from powder in the hopper, and the vibratable member is capable of fluidizing the powder in the hopper. Powder flowing through the outlet under the control of the vibratable member flows into a receptacle or into a transfer chamber for transport to a receptacle.

Abstract: Workstation, apparatuses and methods for the high-throughput synthesis, screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high-throughput methods for synthesis, screening and/or characterization in the same array, without requiring sample transfer from the array. In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. The invention may be practiced at the microscale. The array may comprise thermal channels, for regulating the temperature of the wells in the array. The wells of the array may comprise a membrane, which is used in various screening and characterization methods. The invention also relates to a covered array, comprising the array and an array cover, as well as an apparatus comprising the array, which comprises the array, an array cover and a stage.

Abstract: A method and system for brewing a desired volume of coffee at a selected brew time, in which a volume of water corresponding to the desired volume of coffee is heated and directed into contact with coffee grounds in a brewing chamber. Contact between at least a portion of the heated water and the coffee grounds is maintained for approximately the selected brew time to form brewed coffee. The brewing time, however, is substantially independent of the desired volume of coffee to be brewed and is controlled by control of the rate at which heated liquid flows into or out of the brewing chamber. At the expiration of the brewing time, brewed coffee is released through an opening in the brewing chamber and into an underlying receptacle.

Abstract: Disclosed is a low reaction oscillating mass-based torquing tool wherein an oscillating mass is excited into near resonant oscillation by reversing pulses resulting in increased energy stored in oscillation about a dual stiffness spring which develops a higher torque output with the stiffer spring action in the tightening direction and hence tightens the fastener.

Abstract: A method and system for brewing a desired volume of coffee at a selected brew time, in which a volume of water corresponding to the desired volume of coffee is heated and directed into contact with coffee grounds in a brewing chamber. Contact between at least a portion of the heated water and the coffee grounds is maintained for approximately the selected brew time to form brewed coffee. The brewing time, however, is substantially independent of the desired volume of coffee to be brewed and is controlled by control of the rate at which heated liquid flows into or out of the brewing chamber. At the expiration of the brewing time, brewed coffee is released through an opening in the brewing chamber and into an underlying receptacle.

Abstract: A pulse rate sensor system is packaged in a wristwatch sized assembly and is worn by the user to provide an accurate determination of pulse rate. A tonometer sensor is provided to detect heartbeat pressure waves produced by a superficial artery. A microcomputer manipulates the unprocessed tonometer sensor element signals using multiple algorithms to determine an accurate pulse rate.

Abstract: A method and system for brewing a desired volume of coffee at a selected brew time, in which a volume of water corresponding to the desired volume of coffee is heated and directed into contact with coffee grounds in a brewing chamber. Contact between at least a portion of the heated water and the coffee grounds is maintained for approximately the selected brew time to form brewed coffee. The brewing time, however, is substantially independent of the desired volume of coffee to be brewed and is controlled by control of the rate at which heated liquid flows into or out of the brewing chamber. At the expiration of the brewing time, brewed coffee is released through an opening in the brewing chamber and into an underlying receptacle.