Abstract: Provided herein are, in various embodiments, methods and compositions comprising polyethylene glycol (PEG)-conjugated oligonucleotides (e.g., anti-sense oligonucleotides) for treatment of cancer. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of anti-sense oligonucleotides. In still further embodiments, the disclosure provides methods and compositions for treatment of non-small cell lung cancer.

Abstract: Rapid and accurate quality prediction of resistance spot welding (RSW) for the automotive and other transportation sectors. A machine learning system and method incorporates materials information, e.g., material classification, surface coating, dimensions, stack-up conditions, etc., welding schedule, e.g., current, voltage, force, electrode displacement, welding equipment conditions, e.g., electrode information, water cooling, etc., as well as in-process measurable signals, e.g., heat generation, acoustic emission, etc., and offline weld attribute measurements to determine weld quality metrics. The system and method can also determine a set of resistance spot welding input parameters to produce a desired weld quality.

Abstract: Systems and methods are provided for controlling a HVAC system of a vehicle. An exemplary method may comprise: collecting data describing environmental measurements and one or more states of the HVAC system; predicting one or more target values by inputting the collected data into one or more inference models that include a personal inference model, wherein the personal inference model is used to predict a personal target value for the vehicle or a user of the vehicle; and outputting the one or more target values including the personal target value for the vehicle or the user of the vehicle to control the HVAC system of the vehicle.

Abstract: Disclosed are bottlebrush poly(ethylene glycol) (PEG) polymer-RNA conjugates (pacRNA) having a plurality of PEG side chains attached to a polymer backbone, and one or more RNA oligonucleotides attached to the polymer backbone via a cleavable linkage. The pacRNAs offer potential useful novel RNA-based therapeutics.

Abstract: By adjusting the spacing and length of particle surface moieties on amphiphilic micelles, hybridization kinetics, nuclease resistance, cellular uptake, and antisense efficacy of amphiphilic micelles are fine tuned.