Patents by Inventor Dalia Shallom-Shezifi

Dalia Shallom-Shezifi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
    Publication number: 20190060340
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: November 14, 2018
    Publication date: February 28, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • Aminoglycosides and uses thereof in the treatment of genetic disorders
    Patent number: 10159689
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: December 25, 2018
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
    Publication number: 20180064743
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: November 20, 2017
    Publication date: March 8, 2018
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor BAASOV, Tamar BEN-YOSEF, Igor NUDELMAN, Annie REBIBO-SABBAH, Dalia SHALLOM-SHEZIFI, Mariana HAINRICHSON
  • Aminoglycosides and uses thereof in the treatment of genetic disorders
    Patent number: 9821001
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Grant
    Filed: June 14, 2015
    Date of Patent: November 21, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
    Publication number: 20150352136
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: June 14, 2015
    Publication date: December 10, 2015
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor BAASOV, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • Aminoglycosides and uses thereof in the treatment of genetic disorders
    Patent number: 9073958
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 7, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • Novel aminoglycosides and uses thereof in the treatment of genetic disorders
    Publication number: 20090093418
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 9, 2009
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Timor Bassov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson