Patents by Inventor Dalibor Sames

Dalibor Sames has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11840541
    Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: December 12, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Madalee G. Wulf, Jonathan A. Javitch, Dalibor Sames
  • Publication number: 20230382919
    Abstract: The present invention provides a compound having the structure: wherein D, E and F are each independently NR1, CR2R3 or CR6R7, wherein one of D, E and F is NR1 and the remaining two are CR2R3 or CR6R7, wherein R1 is H or -(alkyl), and wherein R2, R3, R6 and R7 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl or -alkylaryl; X1 is C or N; X2 is O, S, N, NR14 or CR15, wherein R14 is H, -(alkyl) or -cycloalkyl, wherein R15 is H, -(alkyl) or -cycloalkyl, and wherein X2 is other than N when X1 is N; ? and ? represent a bond that is present or absent, and wherein either ? or ? is present, wherein when ? is present, then X1 is C and X2 is O, S or NR14, or when ? is present, then X1 is N and X2 is N or CR15; R4, R5, R8 and R9 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl, -alkylaryl, —OH, —O(alkyl), —OAc, —S(alkyl), —NH2, —NH(alkyl), —N(alkyl)2, —COOH, —CO2(alkyl), —CONH2, —CONH(alk
    Type: Application
    Filed: August 7, 2023
    Publication date: November 30, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Dalibor Sames, Vaclav Havel, Benjamin Bechond, David Lankri
  • Publication number: 20230348465
    Abstract: The present invention provides a compound having the structure: wherein X1 is H or alkyl; Y1 is H, -alkyl, -alkenyl, -alkynyl, alkylaryl, -cycloalkyl, -aryl, heteroaryl, -alkyl-Y3 or -alkyl-C(O)Y4, and Y2 is H, -alkyl, -alkenyl, -alkynyl, alkylaryl, -cycloalkyl, -aryl, heteroaryl, -alkyl-Y3 or -alkyl-C(O)Y4, wherein each Y3 is, independently, —OH, -O(alkyl), —NH2, -NH(alkyl) or halogen, and each Y4 is, independently, —OH, -O(alkyl), —NH2, -NH(alkyl) or -N(alkyl)2; Z1 is H, -alkyl, -alkenyl, -alkynyl, alkylaryl, -aryl, heteroaryl, -alkyl-Z3 or -alkyl-C(O)Z4, and Z2 is H, -alkyl, -alkenyl, -alkynyl, alkylaryl, -aryl, heteroaryl, -alkyl-Z3 or -alkyl-C(O)Z4, wherein each Z3 is, independently, —OH, -O(alkyl), —NH2, -NH(alkyl) or halogen, and each Z4 is, independently, —OH, -O(alkyl), —NH2, -NH(alkyl) or -N(alkyl)2; R1, R2, R3 and R4 are each, independently, —H, —F, —Cl, —Br, —I, —NO2, —CN, —CF3, —CF2H, —OCF3, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), —OH, —OAc, -O-(alkyl), -O-(alkenyl),
    Type: Application
    Filed: July 20, 2021
    Publication date: November 2, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Dalibor Sames, Vaclav Havel, Christopher Hwu
  • Patent number: 11787772
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with a pain, a depressive disorder, a mood disorder, an anxiety disorder, borderline personality disorder, opioid addiction, or opioid withdrawal symptoms by administering the compound to the subject.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: October 17, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew Kruegel, Dalibor Sames, Jonathan A. Javitch
  • Patent number: 11760758
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: September 19, 2023
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC., SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Andrew C. Kruegel, Dalibor Sames, Srijita Bhowmik, Vaclav Havel, Juraj Galeta, Jonathan A. Javitch, Susruta Majumdar
  • Publication number: 20230271976
    Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.
    Type: Application
    Filed: April 7, 2023
    Publication date: August 31, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew C. Kruegel, Madalee G. Wulf, Jonathan A. Javitch, Dalibor Sames
  • Publication number: 20230250098
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the consumption of alcohol in a patient. These compounds may be used in treat or prevent alcoholism or an alcohol abuse disorder and show an improved pharmaceutical profile relative to other commonly used compounds.
    Type: Application
    Filed: October 4, 2022
    Publication date: August 10, 2023
    Applicants: University of Health Sciences & Pharmacy in St. Louis, Purdue Research Foundation, The Trustees of Columbia University in the City of New York
    Inventors: Susruta MAJUMDAR, Richard M. VAN RIJN, Soumen CHAKRABORTY, Balazs VARGA, Anna M. GUTRIDGE, Dalibor SAMES
  • Publication number: 20230102206
    Abstract: The present invention provides a composition which comprises a compound which is a mixture of deuterium containing and non-deuterium containing molecules having the structure: wherein R1 is wherein at least one of H1, H2 or H3 is a deuterium-enriched —H site, or wherein at least one of H1, H2, H3, H4 or H5 is a deuterium-enriched —H site, or a pharmaceutically acceptable salt of the compound, and methods of using the composition to treat pain, depressive disorders, mood disorders, anxiety disorders, opioid use disorders, and opioid withdrawal symptoms.
    Type: Application
    Filed: March 4, 2021
    Publication date: March 30, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Dalibor Sames, Vaclav Havel
  • Publication number: 20220135564
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and methods of using the compound to treat pain, depressive disorders, mood disorders, anxiety disorders, opioid use disorder, and opioid withdrawal symptoms.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 5, 2022
    Applicants: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Andrew C. Kruegel, Dalibor Sames, Jonathan A. Javitch, Susruta Majumdar
  • Publication number: 20220106279
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: July 6, 2021
    Publication date: April 7, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee G. Wulf, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • Publication number: 20210179618
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Application
    Filed: March 2, 2021
    Publication date: June 17, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
  • Publication number: 20210179619
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 17, 2021
    Applicants: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Andrew C. Kruegel, Dalibor Sames, Srijita Bhowmik, Vaclav Havel, Juraj Galeta, Jonathan A. Javitch, Susruta Majumdar
  • Patent number: 10961244
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: March 30, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
  • Patent number: 10844027
    Abstract: The present invention provides a compound having the structure of the instant invention of a pharmaceutically acceptable salt or ester thereof, methods of preparing the same, and methods of treating a subject with compounds of the instant invention in combination therapies.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: November 24, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
  • Publication number: 20200079745
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with a pain, a depressive disorder, a mood disorder, an anxiety disorder, borderline personality disorder, opioid addiction, or opioid withdrawal symptoms by administering the compound to the subject.
    Type: Application
    Filed: March 15, 2018
    Publication date: March 12, 2020
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew Kruegel, Dalibor Sames, Jonathan A. Javitch
  • Publication number: 20190084949
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee M. Wulf, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • Publication number: 20190084983
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Application
    Filed: March 24, 2017
    Publication date: March 21, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
  • Publication number: 20190047970
    Abstract: The present invention provides a compound having the structure of the instant invention of a pharmaceutically acceptable salt or ester thereof, methods of preparing the same, and methods of treating a subject with compounds of the instant invention in combination therapies.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 14, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew KRUEGEL, Dalibor SAMES, Madalee G. WULF, Johnathan A. JAVITCH
  • Patent number: 10183919
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 22, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee M. Gassaway, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • Patent number: 9988377
    Abstract: This invention provides a compound having the structure wherein A is a ring structure, with or without substitution; Z is present or absent and when present is wherein n is 0, 1, 2, 3, or 4; Y is —(CR11R12)—, —NH(CR11R12)—, or —O(CR11R12)—, wherein R11 and R12 are each hydrogen or combine to form a carbonyl; R1, R2, R3, R4, R5 and R6 are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester or amide; ? represents a bond, which is present or absent and when ? is present, then R7 and R8 are absent; R7 and R8 are present when ? is absent and are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester, amide or R5 and R7 combine to form a carbonyl or R6 and R8 combine to form a carbonyl; R9 and R10 are each hydrogen o
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: June 5, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Dalibor Sames, Xiaoguang Li, Shu Li, Andrew Kruegel, Richard Karpowicz, Ignacio Carrera, Souvik Rakshit