Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbonitrile, a modulator of the androgen receptor, and methods for the use in treatment.

Abstract: A method for determining cardiac status comprises for a given patient, constructing a patient-specific, three-dimensional, computational model of the patient's heart; and executing the constructed computational model, said executing generating a quantitative analysis of cardiac function. A method of performing cardiac surgeries comprises: a) assessing surgical options based on a patient-specific, three-dimensional, computational model of a patient's heart; and b) performing surgery based on one or more of the surgical options.

Abstract: A computer system and method are disclosed for automatically generating a vascular model of a blood vessel to support, for example, identification of mechanical factors corresponding to the blood vessel. The method includes interpolating data points corresponding to a contour of the blood vessel; generating a structural model representing three-dimensional structural characteristics of the blood vessel based on interpolated contours; generating a fluid model representing three-dimensional characteristics of fluid flow within the vessel; and generating a vascular model based on the structural model and the fluid model. The method may also include performing a mechanical analysis of the vascular model to identify a mechanical factor associated with the vessel, for example, a factor associated with a potential plaque rupture within the vessel. Embodiments of the invention are applicable to the diagnosis, assessment, or treatment of cardiovascular diseases.

Abstract: A computer system and method are disclosed for automatically generating a vascular model of a blood vessel to support, for example, identification of mechanical factors corresponding to the blood vessel. The method includes interpolating data points corresponding to a contour of the blood vessel; generating a structural model representing three-dimensional structural characteristics of the blood vessel based on interpolated contours; generating a fluid model representing three-dimensional characteristics of fluid flow within the vessel; and generating a vascular model based on the structural model and the fluid model. The method may also include performing a mechanical analysis of the vascular model to identify a mechanical factor associated with the vessel, for example, a factor associated with a potential plaque rupture within the vessel. Embodiments of the invention are applicable to the diagnosis, assessment, or treatment of cardiovascular diseases.

Abstract: A method and a computer system, for providing an assessment for disease status of a disease, such as a cardiovascular disease, employ construction of image-based 3D computational model of an organ representative of the disease status; computationally obtaining a certain mechanical distribution using the 3D-organ model; and computational, quantitative analysis of the mechanical distribution to provide an assessment for disease status of a disease. The image-based 3D computational model includes a fluid-structure interaction and multiple components within the organ.

Abstract: A method for determining cardiac status comprises for a given patient, constructing a patient-specific, three-dimensional, computational model of the patient's heart; and executing the constructed computational model, said executing generating a quantitative analysis of cardiac function. A method of performing cardiac surgeries comprises: a) assessing surgical options based on a patient-specific, three-dimensional, computational model of a patient's heart; and b) performing surgery based on one or more of the surgical options.

Abstract: A method and a computer system, for providing an assessment for disease status of a disease, such as a cardiovascular disease, employ construction of image-based 3D computational model of an organ representative of the disease status; computationally obtaining a certain mechanical distribution using the 3D-organ model; and computational, quantitative analysis of the mechanical distribution to provide an assessment for disease status of a disease. The image-based 3D computational model includes a fluid-structure interaction and multiple components within the organ.