Abstract: The invention relates to antigen binding sites, antibodies and fragments thereof, as well as compositions, kits and uses thereof for the treatment, attenuation and/or prevention of human immunodeficiency virus type 1 (HIV-1).

Abstract: A method for distributing video content across a network, the method comprising: providing video data to a primary data source, associating control data with the video data, broadcasting the video data with associated control data from the primary data source to one or more user devices across the network, providing a media player on the respective user devices which is operable in response to reading the control data to create auxiliary data locally on the respective user devices while the media player is playing the video data, creating the auxiliary data locally on the respective user devices while the media player is playing the video data locally on the respective user devices. The control data defines one or more elements of the auxiliary data to be created by the media player including the elements of the auxiliary data which are to be retrieved from the primary data source and one or more secondary data sources.

Abstract: The invention is directed to polypeptides and polypeptide fragments from HIV-1 envelope (Env) proteins following the characterization of Env structures from environments where HIV isolates expose conserved neutralization-sensitive Env structures. There is provided a polypeptide being all or a fragment of an HIV-1 envelope protein from a transmission strain of HIV-1, the polypeptide having neutralization sensitive epitopes that are accessible.