Abstract: A method for ascertaining the functional patterns of pharmacologically-important compounds by measuring the physiological effect of a plurality of compounds on a plurality of cells comprising the steps of: assaying the plurality of compounds to obtain a first set of data determining the physiological effect of each compound on each cell; assaying at least one known pharmaceutically-important compound to obtain a second set of data determining the physiological effect of the known pharmaceutically-important compound on each cell; and comparing the first and second sets of data to identify a compound having similar physiological effects as the known pharmaceutically-important compound thereby ascertaining its functional patterns.

Abstract: Methods for identifying an ion channel modulator, a target membrane receptor modulator molecule, and other modulatory molecules are disclosed, as well as cells and vectors for use in those methods. A polynucleotide encoding target is provided in a cell under control of an inducible promoter, and candidate modulatory molecules are contacted with the cell after induction of the promoter to ascertain whether a change in a measurable physiological parameter occurs as a result of the candidate modulatory molecule.

Abstract: A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive layer exposed through an aperture in a mask. Beads which are trapped by the attachment areas are released either by a solvent on a vacuum manifold, or by evaporation of the adhesive, preferably by means of a vacuum centrifuge. The beads are released into capillaries, in which cleavage of attached compounds, or synthesis of new compounds, can be carried out. Also invented is the apparatus used in carrying out the invention.

Abstract: hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.

Abstract: hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.

Abstract: Isolated nucleic acid encoding a growth factor receptor binding protein-insulin receptor isoform, protein obtainable from the nucleic acid, recombinant host cells transformed with the nucleic acid and use of the protein and nucleic acid sequence are disclosed.