Patents by Inventor Damien McDevitt

Damien McDevitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • S. aureus fibrinogen binding protein gene
    Publication number: 20070036814
    Abstract: The isolation of genes and proteins from Staphylococcus aureus is provided, and the nucleic acids coding for specific regions of the S. aureus CIfA protein are described. The nucleic acids encode proteins that can be useful as vaccines or in pharmaceutical compositions for application to prevent infection, promotion of wound healing, blocking adherence to indwelling medical devices, or diagnosis of infection.
    Type: Application
    Filed: February 7, 2006
    Publication date: February 15, 2007
    Inventors: Timothy Foster, Damien McDevitt
  • Identification of Targets of Antimicrobial Compounds
    Publication number: 20060240505
    Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
    Type: Application
    Filed: June 28, 2006
    Publication date: October 26, 2006
    Inventors: Frank Fan, Yiping He, Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Martin Rosenberg, Annemarie St. John
  • Whole cell assay
    Publication number: 20060141448
    Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.
    Type: Application
    Filed: February 15, 2006
    Publication date: June 29, 2006
    Inventors: Frank Fan, Yinduo Ji, Howard Kallender, Tong Li, Damien McDevitt
  • Whole cell assay
    Publication number: 20040197767
    Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 7, 2004
    Inventors: Frank Fan, Yinduo Ji, Howard Kallender, Tong Li, Damien McDevitt
  • Identification of targets of antimicrobial compounds
    Publication number: 20040029201
    Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
    Type: Application
    Filed: July 11, 2003
    Publication date: February 12, 2004
    Applicant: SmithKline Beecham Corporation and SmithKline Beecham p.I.c.
    Inventors: Frank Fan, Yiping He, Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Martin Rosenberg, Annemarie C. St, John
  • UPS (undecaprenyl diphosphate synthase
    Patent number: 6537774
    Abstract: The invention provides ups (undecaprenyl diphosphate synthase) polypeptides and polynucleotides encoding ups (undecaprenyl diphosphate synthase) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (undecaprenyl diphosphate synthase) polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: March 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt
  • Ups (ugc)
    Publication number: 20020160447
    Abstract: The invention provides ups (ugc) polypeptides and polynucleotides encoding ups (ugc) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups (ugc) polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 16, 2001
    Publication date: October 31, 2002
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Christopher M. Traini
  • BirA from staphylococcus aureus
    Patent number: 6448038
    Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Howard Kallender, Damien McDevitt, Stephanie Van Horn, Daniel R Sylvester
  • Ups
    Publication number: 20020119512
    Abstract: The invention provides ups polypeptides and polynucleotides encoding ups polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ups polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: September 10, 2001
    Publication date: August 29, 2002
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Stephanie Van Horn
  • Whole cell assay
    Publication number: 20020115217
    Abstract: This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.
    Type: Application
    Filed: October 17, 2001
    Publication date: August 22, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Frank Fan, Yinduo Ji, Howard Kallender, Tong Li, Damien McDevitt
  • pth
    Publication number: 20020106776
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: June 8, 2001
    Publication date: August 8, 2002
    Inventors: Sanjoy Biswas, Martin K. Burnham, Andrew P. Fosberry, John E. Hodgson, Elizabeth J. Lawlor, Tong Li, Damien McDevitt, Christopher Michael Traini, Martin Rosenberg, Judith Ward, Richard Lloyd Warren, Magdalena Zalacain
  • dnaB from Staphylococcus aureus
    Patent number: 6420161
    Abstract: The invention provides dnaB polypeptides and polynucleotides encoding dnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dnaB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: July 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David Lawrence Earnshaw, Earl William May, Damien McDevitt
  • Identification of targets of antimicrobial compounds
    Publication number: 20020086310
    Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
    Type: Application
    Filed: August 30, 2001
    Publication date: July 4, 2002
    Inventors: Frank Fan, Yiping He, Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Martin Rosenberg, Annemarie C. St. John
  • yacM1
    Publication number: 20020064863
    Abstract: The invention provides yacM1 polypeptides and polynucleotides encoding yacM1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yacM1 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Inventors: Martin K. Burnham, David J. Holmes, Michael A. Lonetto, Robert D. Lunsford, Damien McDevitt, Daniel Sylvester, Stephanie Van Horn, Magdalena Zalacain
  • yacM2
    Publication number: 20020064827
    Abstract: The invention provides yacM2 polypeptides and polynucleotides encoding yacM2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yacM2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assaysto screen for microbial infections in organisms and materials.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Inventors: Martin K. R. Burnham, David J. Holmes, Robert D. Lunsford, Damien McDevitt, Daniel Sylvester, Stephanie Van Horn, Magdalena Zalacain
  • PcrA helicase
    Patent number: 6391600
    Abstract: The invention provides PcrA Helicase polypeptides and polynucleotides encodi PcrA Helicase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing PcrA Helicase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 21, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Damien McDevitt, Earl May, Annemarie St John, Stephanie Van Horn
  • yneS
    Publication number: 20020058789
    Abstract: The invention provides yneS polypeptides and polynucleotides encoding yneS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yneS polypeptides and polynucleotides as diagnostic reagents and in diagnostic assaysto screen for microbial infections in organisms and materials.
    Type: Application
    Filed: March 30, 2001
    Publication date: May 16, 2002
    Inventors: Sanjoy Biswas, Martin K. R. Burnham, Damien McDevitt, Daniel R. Sylvester, Patrick V. Warren, Magdalena Zalacain
  • birA
    Publication number: 20020048789
    Abstract: The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing birA polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 17, 2001
    Publication date: April 25, 2002
    Inventors: Jianzhong Huang, Damien McDevitt
  • yybQ
    Publication number: 20020042123
    Abstract: The invention provides yybQ polypeptides and polynucleotides encoding yybQ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yybQ polypeptides and polynucleotides as diagnostic reagents and in diagnostic assaysto screen for microbial infections in organisms and materials.
    Type: Application
    Filed: March 30, 2001
    Publication date: April 11, 2002
    Inventors: Martin K. R. Burnham, Robert D. Lunsford, Damien McDevitt, Mihai-Serban Iordanescu
  • TktA
    Publication number: 20020039759
    Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ttA polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 21, 2001
    Publication date: April 4, 2002
    Inventors: Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Stephanie Van Horn