Patents by Inventor Damilola Daniel Phillips

Damilola Daniel Phillips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered anthrax lethal toxin for targeted delivery
    Patent number: 9730993
    Abstract: The present invention provides methods and systems for targeted delivery of a compound to a target cell that over-expresses two different proteinases. Specifically, two different modified protective antigen proteins, each comprising a cleavage site recognized by a distinct proteinase in place of the native proteinase cleavage site recognized by furin, are administered in combination with a compound that contains a protective antigen binding site. Upon cleavage by the two proteinases the two modified protective antigen proteins form a hetero-oligomer, allowing the compound to bind to the hetero-oligomer and subsequently to be translocated into the target cell.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: August 15, 2017
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Clinton Edward Leysath, Stephen H Leppla, Damilola Daniel Phillips
  • ENGINEERED ANTHRAX LETHAL TOXIN FOR TARGETED DELIVERY
    Publication number: 20150224184
    Abstract: The present invention provides methods and systems for targeted delivery of a compound to a target cell that overexpresses two different proteinases. Specifically, two different modified protective antigen proteins, each comprising a cleavage site recognized by a distinct proteinase in place of the native proteinase cleavage site recognized by furin, are administered in combination with a compound that contains a protective antigen binding site. Upon cleavage by the two proteinases the two modified protective antigen proteins form a hetero-oligomer, allowing the compound to bind to the hetero-oligomer and subsequently to be translocated into the target cell.
    Type: Application
    Filed: August 22, 2013
    Publication date: August 13, 2015
    Inventors: Clinton Edward Leysath, Stephen H. Leppla, Damilola Daniel Phillips