Abstract: Examples of the presently disclosed technology provide new systems and methods for performing direct targeting for DBS procedures (and other related procedures) using a single pre-operative scan of a patient's brain. Examples can achieve this single-scan direct targeting by leveraging mesh vertex-based correspondences between patient-specific 3D mesh brain structure representations across prospective and historical DBS procedures. Examples can leverage such correspondences to accurately predict DBS lead placement coordinates for a prospective DBS procedure based on historical DBS lead placement coordinates from the historical DBS procedures. Accordingly, a clinician performing the prospective DBS procedure can utilize the predicted DBS lead placement coordinates for surgical planning purposes.

Abstract: Systems and methods are provided that automatically determine whether a prospective surgical trajectory will collide with a patient's skull using a 3D representation of the patient's cranial region (including the patient's scalp, skull, and brain) adapted from imaging data of the patient's cranial region (e.g., MRI data or CT data). Taking a particular patient's varied skull thickness into account, examples can determine bone collision during a trajectory planning stage before or after a stereotactic frame is mounted to the patient. Accordingly, examples may preemptively alert a clinician to a potential bone collision before the prospective surgical trajectory is underway/has been executed, thereby reducing the risk of bone collision during the surgical procedure.

Abstract: Systems and methods provide automated systems for accurately estimating infusion coverage within a target brain region in real-time (or approximately real-time) during surgical procedures. Such accurate and real-time infusion coverage estimation enables intraoperative monitoring and adjustment of infusion parameters (e.g., cannula tip location, infusate delivery flow rate, etc.) for achieving optimal/improved infusion coverage for a given drug therapy. Accordingly, examples of the presently disclosed technology can improve the efficacy and safety of drug therapies delivered to the brain.

Abstract: Examples of the presently disclosed technology provide new systems and methods for performing direct targeting for DBS procedures (and other related procedures) using a single pre-operative scan of a patient's brain. Examples can achieve this single-scan direct targeting by leveraging mesh vertex-based correspondences between patient-specific 3D mesh brain structure representations across prospective and historical DBS procedures. Examples can leverage such correspondences to accurately predict DBS lead placement coordinates for a prospective DBS procedure based on historical DBS lead placement coordinates from the historical DBS procedures. Accordingly, a clinician performing the prospective DBS procedure can utilize the predicted DBS lead placement coordinates for surgical planning purposes.

Abstract: Systems and methods provide a neurosurgeon with real-time feedback on safety of prospective surgical trajectories, which can simultaneously reduce surgical intervention times and improve patient safety. Examples can determine a level of safety for a prospective surgical trajectory by determining a number of times that a prospective surgical trajectory representation (e.g., a 1D line representing a prospective surgical trajectory) intersects (a) a patient-specific 3D cortical surface representation (i.e., a 3D representation representing an exterior surface of the patient's brain cortex); and (b) one or more patient-specific 3D hazard brain region representations (e.g., 3D representations representing hazard brain regions of the patient to be avoided during surgery).

Abstract: Systems and methods provide automated systems for accurately estimating infusion coverage within a target brain region in real-time (or approximately real-time) during surgical procedures. Such accurate and real-time infusion coverage estimation enables intraoperative monitoring and adjustment of infusion parameters (e.g., cannula tip location, infusate delivery flow rate, etc.) for achieving optimal/improved infusion coverage for a given drug therapy. Accordingly, examples of the presently disclosed technology can improve the efficacy and safety of drug therapies delivered to the brain.

Abstract: Systems and methods are provided that automatically determine whether a prospective surgical trajectory will collide with a patient's skull using a 3D representation of the patient's cranial region (including the patient's scalp, skull, and brain) adapted from imaging data of the patient's cranial region (e.g., MRI data or CT data). Taking a particular patient's varied skull thickness into account, examples can determine bone collision during a trajectory planning stage before or after a stereotactic frame is mounted to the patient. Accordingly, examples may preemptively alert a clinician to a potential bone collision before the prospective surgical trajectory is underway/has been executed, thereby reducing the risk of bone collision during the surgical procedure.