Abstract: A cell population (55) is cultured on a cell culture substrate (50) while agents contained in agent reservoirs (31, 33, 35) at predefined positions in a culture container (10) diffuse through the substrate (50) and form at least partly overlapping concentration gradients in the substrate (50) within combination areas (41, 43, 45) and substantially non-overlapping concentration gradients in the substrate (50) peripheral to an outer boundary of the agent reservoirs (31, 33, 35). Inhibition end points (61, 63, 65) of respective inhibition zones (60, 62, 64) substantially lacking any growth of the cell population (55) peripheral to the outer boundary of the agent reservoirs (31, 33, 35) and growth end points (71, 73, 75) of respective growth zones (70, 72, 74) comprising growth of the cell population (55) within the combination areas (41, 43, 45) are determined and used to determine interaction effects between the agents on the cell population (55).

Abstract: The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.

Abstract: The present invention relates to pharmaceutical compositions comprising colloidal dispersions of silica particles to which silver ions have been adsorbed in combination with therapeutically active agents. It is also related to a kit of parts, uses and medical methods of treatment involving said pharmaceutical compositions or the components of said pharmaceutical composition. The invention provides means for alternative treatment strategies for bacterial infections to lessen the need for traditional antibiotics.

Abstract: The present invention relates to a method for monitoring operational status in continuous chromatography configured to operate with at least three columns adapted for cyclic use for continuous purification of a target product when feeding the continuous chromatography with a sample containing the target product. The method comprises detecting (81) at least one parameter indicative of a selected function in the continuous chromatography, performing (82) real time trend analysis of the detected parameter to identify a deviating behaviour of the selected function, and initiate (83) actions to eliminate or reduce the effect of the identified deviating behaviour where by the performance of the continuous chromatography is maintained.

Abstract: An apparatus (24) for inserting an endless, flexible clothing (15) in or removing such a clothing from an industrial machine in which the clothing is arranged to run in an endless loop, comprising first and second units (25, 26) between which the clothing is to be fed in an advancement direction (F) essentially transversal to the run direction of the clothing in the machine.

Abstract: An apparatus (24) for inserting an endless, flexible clothing (15) in or removing such a clothing from an industrial machine in which the clothing is arranged to run in an endless loop, comprising first and second units (25, 26) between which the clothing is to be fed in an advancement direction (F) essentially transversal to the run direction of the clothing in the machine.