Patents by Inventor Dan-Avi LANDAU

Dan-Avi LANDAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INDUCING AN IMMUNOMODULATORY TUMOR RESPONSE
    Publication number: 20240043539
    Abstract: The present disclosure relates to methods of inducing an immunomodulatory tumor response for the treatment of a subject having a tumor. The disclosure further relates to an organotypic tumor micro environment culture system that can be utilized to screen and identify novel immunomodulatory cancer therapeutics.
    Type: Application
    Filed: December 8, 2021
    Publication date: February 8, 2024
    Inventors: Dan-Avi LANDAU, Nir BEN-CHETRIT
  • Compositions and methods for diagnosing, evaluating and treating cancer by means of the DNA methylation status
    Patent number: 11834718
    Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: December 5, 2023
    Assignees: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Mark Kendell Clement, Gad Getz, Dan-Avi Landau, Alexander Meissner, Catherine Ju-Ying Wu
  • SYSTEMS AND METHODS FOR DETECTION OF RESIDUAL DISEASE
    Publication number: 20230295738
    Abstract: The disclosure relates to systems, software, and methods for the detection of residual disease, e.g., residual tumor disease, in subjects, e.g., human cancer patients.
    Type: Application
    Filed: April 12, 2023
    Publication date: September 21, 2023
    Inventors: Dan Avi LANDAU, Asaf Ari ZVIRAN, Viktor A. ADALSTEINSSON
  • ULTRA-SENSITIVE DETECTION OF CIRCULATING TUMOR DNA THROUGH GENOME-WIDE INTEGRATION
    Publication number: 20210043275
    Abstract: The disclosure relates to systems, software and methods for diagnosing tumor diseases in a patient.
    Type: Application
    Filed: February 27, 2019
    Publication date: February 11, 2021
    Inventors: Dan Avi LANDAU, Asaf ZVIRAN, Steven KOTHEN-HILL
  • SYSTEMS AND METHODS FOR DETECTION OF RESIDUAL DISEASE
    Publication number: 20210002728
    Abstract: The disclosure relates to systems, software, and methods for the detection of residual disease, e.g., residual tumor disease, in subjects, e.g., human cancer patients.
    Type: Application
    Filed: February 27, 2019
    Publication date: January 7, 2021
    Inventors: Dan Avi LANDAU, Asaf ZVIRAN, Viktor A. ADALSTEINSSON
  • COMPOSITIONS AND METHODS FOR DIAGNOSING, EVALUATING AND TREATING CANCER BY MEANS OF THE DNA METHYLATION STATUS
    Publication number: 20200407804
    Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 31, 2020
    Inventors: Mark K. Clement, Gad Getz, Dan-Avi Landau, Alexander Meissner, Catherine J. Wu
  • Compositions and methods for diagnosing, evaluating and treating cancer
    Patent number: 10801070
    Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: October 13, 2020
    Assignees: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Mark Kendell Clement, Gad Getz, Dan-Avi Landau, Alexander Meissner, Catherine Ju-Ying Wu
  • USE OF CLONAL EVOLUTION ANALYSIS FOR IBRUTINIB RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
    Publication number: 20170298441
    Abstract: The present invention generally relates to the methods and use of clonal evolution analysis of the kinetics and genetic alterations associated with the development of resistance to a therapy using whole-exome and deep targeted sequencing in treating patients in need thereof.
    Type: Application
    Filed: September 22, 2015
    Publication date: October 19, 2017
    Inventors: Catherine J. WU, Dan-Avi LANDAU, Jan A. BURGER, Ivana Bozic, MARTIN NOWAK
  • COMPOSITIONS AND METHODS FOR DIAGNOSING, EVALUATING AND TREATING CANCER
    Publication number: 20160326593
    Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
    Type: Application
    Filed: November 24, 2014
    Publication date: November 10, 2016
    Inventors: Mark Kendell Clement, Gad GETZ, Dan-Avi LANDAU, Alexander MEISSNER, Catherine Ju-Ying WU