Patents by Inventor Dan E. Gutfinger

Dan E. Gutfinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210059651
    Abstract: The present disclosure is directed to embodiments and methods of reducing or eliminating erosion resulting from the use of an occluder, as well as reducing or eliminating other interference with cardiac tissue by an occluder, including reducing pressure on cardiac tissue, minimizing micro-perforations, and/or minimizing residual leak by improving sealing around the occluder. In particular, the present disclosure is directed to providing an external skirt on an occluder that improves sealing of the occluder while reducing interference with the cardiac tissue by the occluder.
    Type: Application
    Filed: August 27, 2020
    Publication date: March 4, 2021
    Inventors: Dan E. Gutfinger, Michael P Meyer, Pankaj Gupta
  • Publication number: 20210059684
    Abstract: The present disclosure is directed to embodiments and methods of reducing or eliminating erosion resulting from the use of an occluder. In particular, the present disclosure is directed to reducing or eliminating erosion resulting from the use of an occluder while maintaining the fundamental function and effectiveness of the occluder with an improved occluder braid pattern. The embodiments and methods disclosed herein reduce or eliminate erosion, for example, by reducing the friction and force of an occluder on cardiac tissue and/or by increasing occluder disc compliance to cardiac structures and movement.
    Type: Application
    Filed: August 27, 2020
    Publication date: March 4, 2021
    Inventors: Michael P. Meyer, Dan E. Gutfinger, Pankaj Gupta, Brian Perszyk, Alex Bloomquist, Hanna Williams, Erika Beek
  • Patent number: 9462959
    Abstract: In specific embodiments, a method to monitor left atrial pressure and/or intra-thoracic fluid volume of a patient, comprises (a) monitoring posture of the patient using a posture sensor implanted within the patient, and (b) using portions of an impedance signal, obtained using implanted electrodes, to monitor the left atrial pressure and/or intra-thoracic fluid volume of the patient. Each portion of the impedance signal used to monitor the left atrial pressure and/or intra-thoracic fluid volume of the patient corresponds to a period after which the patient has maintained a predetermined posture for at least a predetermined period of time, and during which the patient has remained in the predetermined posture.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: October 11, 2016
    Assignee: Pacesetter, Inc.
    Inventors: Yelena Nabutovsky, Fujian Qu, Steve Koh, Dan E. Gutfinger, Alex Soriano
  • Publication number: 20150223702
    Abstract: Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 13, 2015
    Inventors: Guy Vanney, Thao Ngo, Scott Sjoquist, Dorab N. Sethna, Annapurna Karicherla, George K. Lewis, Dan E. Gutfinger, Gene A. Bornzin
  • Patent number: 9066662
    Abstract: Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: June 30, 2015
    Assignee: Pacesetter, Inc.
    Inventors: Brian J. Wenzel, Dan E. Gutfinger, Mihir Naware, Xiaoyi Min, Jeffery Siou, Anders Bjorling, Dorin Panescu
  • Publication number: 20150025397
    Abstract: Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
    Type: Application
    Filed: July 16, 2013
    Publication date: January 22, 2015
    Inventors: Brian J. Wenzel, Dan E. Gutfinger, Mihir Naware, Xiaoyi Min, Jeffery Siou, Anders Bjorling, Dorin Panescu
  • Patent number: 8812093
    Abstract: Various techniques are provided for use with an implantable medical device for exploiting near-field impedance/admittance. Examples include techniques for assessing heart chamber disequilibrium, detecting chamber volumes and pressures, calibrating near-field-based left atrial pressure (LAP) estimation procedures and for assessing the recovery from injury at the electrode-tissue interface. In one particular example, the implantable device assesses the degree of concordance between the left ventricle (LV) and the right ventricle (RV) by quantifying a degree of scatter between LV and RV near-field admittance values. An increase in RV admittance is indicative of RV failure, an increase in LV admittance is indicative of LV failure, and an increase in both LV and RV admittance is indicative of biventricular failure.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: August 19, 2014
    Assignee: Pacesetter, Inc.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah
  • Patent number: 8784323
    Abstract: In specific embodiments, a method to monitor pulmonary edema of a patient, comprises (a) detecting, using an implanted posture sensor, when a posture of the patient changes from a first predetermined posture to a second predetermined posture, (b) determining an amount of time it takes an impedance signal to achieve a steady state after the posture of the patient changes from the first predetermined posture to the second predetermined posture, where the impedance signal is obtained using implanted electrodes and is indicative of left atrial pressure and/or intra-thoracic fluid volume of the patient, and (c) monitoring the pulmonary edema of the patient based on the determined amount of time it takes the impedance signal to achieve the steady state after the posture of the patient changes from the first predetermined posture to the second pre-determined posture.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: July 22, 2014
    Assignee: Pacesetter, Inc.
    Inventors: Yelena Nabutovsky, Fujian Qu, Steve Koh, Dan E. Gutfinger, Alex Soriano
  • Patent number: 8670820
    Abstract: A new model is provided for understanding and exploiting impedance or admittance values measured by implantable medical devices, such as pacemakers or cardiac resynchronization devices (CRTs.) The device measures impedance along vectors extending through tissues of the patient between various pairs of electrodes. The device then converts the vector-based impedance measurements into near-field individual electrode-based impedance values. This is accomplished, in at least some examples, by converting the vector-based impedance measurements into a set of linear equations to be solved while ignoring far-field contributions to the impedance measurements. The device solves the linear equations to determine the near-field impedance values for the individual electrodes, which are representative of the impedance of tissues in the vicinity of the electrodes.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: March 11, 2014
    Assignee: Pacesetter, Inc.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah, Andreas Blomqvist
  • Patent number: 8504153
    Abstract: Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 6, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Brian Jeffrey Wenzel, Dan E. Gutfinger, Mihir Naware, Xiaoyi Min, Jeffery Siou, Anders Bjorling, Dorin Panescu
  • Patent number: 8504152
    Abstract: Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 6, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Brian Jeffrey Wenzel, Dan E. Gutfinger, Mihir Naware, Xiaoyi Min, Jeffery Siou, Anders Bjorling, Dorin Panescu
  • Publication number: 20120197141
    Abstract: Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta.
    Type: Application
    Filed: January 28, 2011
    Publication date: August 2, 2012
    Applicant: PACESETTER, INC.
    Inventors: Guy Vanney, Thao Ngo, Scott Sjoquist, Dorab N. Sethna, Annapurna Karicherla, George K. Lewis, Dan E. Gutfinger, Gene A. Bornzin
  • Publication number: 20120184859
    Abstract: Various techniques are provided for assessing the reliability of left atrial pressure (LAP) estimates made by an implantable medical device based on impedance values or related electrical values. In one example, various cardioelectric and cardiomechanical parameters are used to corroborate LAP estimation in circumstances where the LAP estimates deviate from an acceptable, satisfactory or otherwise healthy range. The cardioelectric parameters include, e.g.: ST elevation; heart rate (HR); heart rate variability (HRV); T-wave alternans (TWA); QRS waveform parameters; P-wave duration; evoked response (ER) parameters; and intrinsic PV/AV/VV conduction delays. The cardiomechanical parameters include, e.g.: heart rate turbulence (HRT); cardiogenic impedance signals; heart sounds; and non-LAP blood pressure measurements, such as aortic pressure measurements.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 19, 2012
    Applicant: PACESETTER, INC.
    Inventors: Riddhi Shah, Fujian Qu, Yelena Nabutovsky, Dan E. Gutfinger, Ryan Rooke, Alex Soriano
  • Patent number: 8202224
    Abstract: Various techniques are provided for calibrating and estimating left atrial pressure (LAP) using an implantable medical device, based on impedance, admittance or conductance parameters measured within a patient. In one example, default conversion factors are exploited for converting the measured parameters to estimates of LAP. The default conversion factors are derived from populations of patients. In another example, a correlation between individual conversion factors is exploited to allow for more efficient calibration. In yet another example, differences in thoracic fluid states are exploited during calibration. In still yet another example, a multiple stage calibration procedure is described, wherein both invasive and noninvasive calibration techniques are exploited. In a still further example, a therapy control procedure is provided, which exploits day time and night time impedance/admittance measurements.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: June 19, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Dan E. Gutfinger, Neal L. Eigler, Dorin Panescu, James S. Whiting
  • Patent number: 8135468
    Abstract: Various techniques are provided for use with an implantable medical device for estimating cardiac pressure within a patient based on admittance (or related electrical values such as impedance or conductance) that takes into account the presence of acute MR within the patient. Briefly, the device detects an indication of acute MR, if occurring within the patient. The device also applies electrical fields to tissues of the patient and measures electrical parameters influenced by the electrical field, such as admittance, impedance or conductance. The device then estimates cardiac pressure within the patient based on the measured electrical parameter and the indication of acute MR. In one example, different linear correlation functions are used to convert admittance values to left atrial pressure (LAP) values depending upon the presence or absence of acute MR within the patient.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: March 13, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah
  • Publication number: 20120035681
    Abstract: Various techniques are provided for use with an implantable medical device for estimating cardiac pressure within a patient based on admittance (or related electrical values such as impedance or conductance) that takes into account the presence of acute MR within the patient. Briefly, the device detects an indication of acute MR, if occurring within the patient. The device also applies electrical fields to tissues of the patient and measures electrical parameters influenced by the electrical field, such as admittance, impedance or conductance. The device then estimates cardiac pressure within the patient based on the measured electrical parameter and the indication of acute MR. In one example, different linear correlation functions are used to convert admittance values to left atrial pressure (LAP) values depending upon the presence or absence of acute MR within the patient.
    Type: Application
    Filed: August 9, 2010
    Publication date: February 9, 2012
    Applicant: PACESETTER, INC.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah
  • Publication number: 20120035493
    Abstract: A new model is provided for understanding and exploiting impedance or admittance values measured by implantable medical devices, such as pacemakers or cardiac resynchronization devices (CRTs.) The device measures impedance along vectors extending through tissues of the patient between various pairs of electrodes. The device then converts the vector-based impedance measurements into near-field individual electrode-based impedance values. This is accomplished, in at least some examples, by converting the vector-based impedance measurements into a set of linear equations to be solved while ignoring far-field contributions to the impedance measurements. The device solves the linear equations to determine the near-field impedance values for the individual electrodes, which are representative of the impedance of tissues in the vicinity of the electrodes.
    Type: Application
    Filed: August 9, 2010
    Publication date: February 9, 2012
    Applicant: PACESETTER, INC.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah, Andreas Blomqvist
  • Publication number: 20120035495
    Abstract: Various techniques are provided for use with an implantable medical device for exploiting near-field impedance/admittance. Examples include techniques for assessing heart chamber disequilibrium, detecting chamber volumes and pressures, calibrating near-field-based left atrial pressure (LAP) estimation procedures and for assessing the recovery from injury at the electrode-tissue interface. In one particular example, the implantable device assesses the degree of concordance between the left ventricle (LV) and the right ventricle (RV) by quantifying a degree of scatter between LV and RV near-field admittance values. An increase in RV admittance is indicative of RV failure, an increase in LV admittance is indicative of LV failure, and an increase in both LV and RV admittance is indicative of biventricular failure.
    Type: Application
    Filed: January 14, 2011
    Publication date: February 9, 2012
    Applicant: PACESETTER, INC.
    Inventors: Dan E. Gutfinger, Fujian Qu, Alex Soriano, Ryan Rooke, Yelena Nabutovsky, Riddhi Shah
  • Publication number: 20110238102
    Abstract: Access to the left side of the heart is gained through a heart wall. A delivery instrument includes a guide that may include or carry a puncturing instrument that is adapted to be directed toward the heart wall. In some embodiments a distal portion of the delivery instrument may be adapted to be co-located with the coronary sinus. In addition, the guide may be located a known distance from the portion of the delivery instrument that is co-located with the coronary sinus. Access to the left side of the heart may thus be readily gained by positioning the delivery instrument relative to the coronary sinus.
    Type: Application
    Filed: June 3, 2011
    Publication date: September 29, 2011
    Applicant: PACESETTER, INC.
    Inventors: Dan E. Gutfinger, Paul Hindrichs, Phong D. Doan
  • Publication number: 20110208083
    Abstract: An implantable medical device includes electrodes that are configured to be positioned within at least one of a heart and a chest wall of a patient. The device also includes an impedance measurement module, a patient position sensor, and a correction module. The impedance measurement module measures an impedance vector between a predetermined combination of the electrodes. The patient position sensor determines at least one of a posture and an activity level of the patient. The correction module adjusts the impedance vector based on the at least one of the posture and the activity level of the patient.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 25, 2011
    Applicant: PACESETTER, INC.
    Inventor: Dan E. Gutfinger