Patents by Inventor Dan Gao
Dan Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240139456Abstract: FIGS. 1-16D & 66A-92D disclose a large variety of methods of forming the headgear for use in combination with a breathing apparatus including a unitary plastic core within textile casings. In some configurations, the plastic core material penetrates or bursts-through the textile casing of the straps. Some configurations include over moulding, alignment posts, T-joints and joint housings with injection aperture. FIGS. 17-65 & 93A-94C disclose a large variety of different headgear arrangements including top strap, front strap, rear strap and pairs of straps extending from the mask above and below the ear to meet behind the ear. FIGS. 95-121B disclose a large variety of connectors connecting the headgear assembly to the mask assembly where the headgear, mask and connector form a closed loop when the connector is disengaged with the mask assembly.Type: ApplicationFiled: November 14, 2023Publication date: May 2, 2024Inventors: Paul Mathew Freestone, Janine Elizabeth Collins, Ryan Anthony Graham, Vitaly Kapelevich, Melissa Catherine Bornholdt, Sophie Kathryn Randles, Silas Sao Jin Siew, Steve Thomas, Ronan Leahy, Max Leon Betteridge, Callum Ross Gordon, Vicky Dan Gao, Cameron Robert Willis
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Publication number: 20240131086Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.Type: ApplicationFiled: October 9, 2022Publication date: April 25, 2024Inventors: Yong Wang, Yuanyuan Liu, Wenhua Zhang, Yanqiu Xing, Shaopeng Wang, Dan Wang, Hong Zhu, Xinglu Xu, Shengbiao Jiang, Xiaonan Li, Jiahui Zheng, Rong Zhang, Dongxia Yang, Yuxia Gao, Shili Shao, Ting Han
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Publication number: 20240115627Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.Type: ApplicationFiled: October 9, 2022Publication date: April 11, 2024Inventors: Yong Wang, Hong Zhu, Wenhua Zhang, Yanqiu Xing, Dan Wang, Yuanyuan Liu, Shaopeng Wang, Jiahui Zheng, Rong Zhang, Xiaonan Li, Xinglu Xu, Shengbiao Jiang, Lichao Xing, Yuxia Gao, Shili Shao, Ting Han
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Patent number: 11951120Abstract: This invention relates to the fields of mRNA vaccines, mRNA therapy, and gene therapy and specifically to the use of gene expression vectors or PCR amplicons containing various 5?UTR sequences followed by coding sequences for in vitro and in vivo production of mRNA or proteins of interest.Type: GrantFiled: December 7, 2022Date of Patent: April 9, 2024Inventors: Jaewoo Lee, Dehua Wang, Xiaoyao Hao, Yue Gao, Jie Liu, Shan He, Ting He, Dan Tse
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Patent number: 11946002Abstract: Provided is a method for treating an oil gas, which can realize high-efficiency separation for and recovery of gasoline components, C2, C3, and C4 components. The method first conducts separation of light hydrocarbon components from gasoline components, and then performs subsequent treatment on a stream rich in the light hydrocarbon components, during which it is no longer necessary to use gasoline to circularly absorb liquefied gas components, which significantly reduces the amount of gasoline to be circulated and reduces energy consumption throughout the separation process. Besides, in this method, impurities, such as H2S and mercaptans, in the stream rich in the light hydrocarbon components are removed first before the separation for the components. This ensures that impurities will not be carried to a downstream light hydrocarbon recovery section, thus avoiding corrosion issues caused by hydrogen sulfide in the light hydrocarbon recovery section.Type: GrantFiled: June 5, 2020Date of Patent: April 2, 2024Assignees: SINOPEC ENGINEERING INCORPORATION, SINOPEC ENGINEERING (GROUP) CO., LTD.Inventors: Mengqi Huang, Longhong Yu, Lei Wu, Shengyang Jiang, Yuwen Ding, Na Gao, Di Wu, Dan Duan
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Publication number: 20240077423Abstract: A transcriptional regulator specifically responding to D-2-hydroxyglutarate (D-2-HG) and its application in the biological detection of D-2-HG. Wherein the transcriptional regulator is named DhdR and the nucleotide sequence is shown as SEQ ID NO: 1. The D-2-HG biosensors BD2HG-0 and BD2HG-1 are constructed using the transcriptional regulator DhdR and can detect biological samples containing D-2-HG.Type: ApplicationFiled: March 21, 2021Publication date: March 7, 2024Applicant: SHANDONG UNIVERSITYInventors: Chao GAO, Dan XIAO, Wen ZHANG, Cuiqing MA, Ping XU
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Patent number: 11920168Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated AA V capsid proteins having terminally grafted nucleases and isolated nucleic acids encoding the same. Recent approaches to delivering nucleases to cells for gene editing have focused on delivering of expression vectors engineered to express the nucleases in target cells. However, these approaches have proved to be problematic in many instances due to genotoxicity resulting from to prolonged expression of gene editing system in vivo. To prevent such off-target genotoxicity due to prolonged presence of a gene editing system, several studies explored delivery of mRNA or protein instead of delivering the gene coding for the nucleases in cell culture.Type: GrantFiled: January 29, 2020Date of Patent: March 5, 2024Assignee: University of MassachusettsInventors: Guangping Gao, Phillip D. Zamore, Dan Wang
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Patent number: 11920472Abstract: A reasonable millisecond time control method for excavation blasting of a tunnel is provided, and includes: acquiring physical mechanical parameters to establish a millisecond blasting model, and designing four dimensions blasting parameters of explosive quantity, hole number, inter-hole millisecond and inter-row millisecond; simulating, based on the millisecond blasting model, a blasting process of an explosive package using blasting parameters to obtain a blasting vibration curve; obtaining single-hole blasting vibration waveforms, solving a vibration synthesis curve through a vibration synthesis theory; comparing the vibration synthesis curve with the blasting vibration curve to obtain a coupling relationship of blasting parameters; determining a target group of explosive quantity and hole numbers, determining a target millisecond through the coupling relationship of blasting parameters, and relating a millisecond blasting control strategy to control, and it is used for tunneling project to reduce cut blasType: GrantFiled: September 20, 2023Date of Patent: March 5, 2024Assignees: CHINA RAILWAY ELEVENTH BUREAU GROUP CO., LTD, CHINA RAILWAY ELEVENTH BUREAU GROUP FOURTH ENGINEERING CO., LTD., WUJIU RAILWAY PASSENGER DEDICATED LINE HUBEI CO., LTD, CHINA RAILWAY FOURTH BUREAU GROUP CO., LTD, ANHUI CHINA RAILWAY ENGINEERING TECHNOLOGY SERVICE CO., LTD, WUHAN INSTITUTE OF GEOTECHNICAL MECHANICS, CHINESE ACADEMY OF SCIENCES, CHINA RAILWAY SOUTHWEST SCIENTIFIC RESEARCH INSTITUTE CO., LTDInventors: Jun Gao, Liyun Yang, Xiao Lin, Ming Zhang, kaiwen Liu, Xiaowei Zuo, Bin Zhou, Feng Wang, Yuxin Gao, Dan Xu, Ling Wang, Zhengyi Wang, Xiaokai Wen, Yongtai Wang, Huiling Xue
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Publication number: 20240058560Abstract: The disclosure relates to a patient interface for non-invasive ventilation. The patient interface is configured to seal about the mouth and nares of a patient and includes an outer wall defining an interior volume which includes a first chamber having one or more oral openings to communicate gas with the mouth and a second chamber having one or more nare openings to communicate gas with the nares. The patient interface further includes a dividing wall that separates the first chamber from the second chamber. The patient interface further includes one or more flow directors which enable gas to flow into the second chamber from the first chamber the first chamber from the second chamber. The one or more flow directors are configured to direct the gas flow through the one or more nare openings.Type: ApplicationFiled: January 12, 2022Publication date: February 22, 2024Inventors: James Alexander GORDON, Sascha Kristopher ZOELLNER, Joseph Jules NIHOTTE, Ashani Melisha PERERA, Vicky Dan GAO, Neil Gray DUTHIE, Saachi SHAHRI, Frederic Walter Williamson STRAUSS, Christopher WHARMBY, Ryan Anthony GRAHAM, Andre VAN SCHALKWYK
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Patent number: 11850365Abstract: FIGS. 1-16D & 66A-92D disclose a large variety of methods of forming the headgear for use in combination with a breathing apparatus comprising a unitary plastic core within textile casings. In some configurations, the plastic core material penetrates or bursts-through the textile casing of the straps. Some configurations include over moulding, alignment posts, T-joints and joint housings with injection aperture. FIGS. 17-65 & 93A-94C disclose a large variety of different headgear arrangements including top strap, front strap, rear strap and pairs of straps extending from the mask above and below the ear to meet behind the ear. FIGS. 95-121B disclose a large variety of connectors connecting the headgear assembly to the mask assembly where the headgear, mask and connector form a closed loop the connector is disengaged with the mask assembly.Type: GrantFiled: January 4, 2022Date of Patent: December 26, 2023Assignee: Fisher & Paykel Healthcare LimitedInventors: Paul Mathew Freestone, Janine Elizabeth Collins, Ryan Anthony Graham, Vitaly Kapelevich, Melissa Catherine Bornholdt, Sophie Kathryn Randles, Silas Sao Jin Siew, Steve Thomas, Ronan Leahy, Max Leon Betteridge, Callum Ross Gordon, Vicky Dan Gao, Cameron Robert Willis
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Patent number: 11605820Abstract: An electrical energy generating element includes a first porous electrode, an eggshell membrane, and a second porous electrode. The first porous electrode, the eggshell membrane, and the second porous electrode are stacked on each other in that order. The present application also relates to an electrical energy generating device, a method for generating electrical energy, and a decorative ring.Type: GrantFiled: June 28, 2019Date of Patent: March 14, 2023Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Dan Gao, Chang-Hong Liu, Shou-Shan Fan
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Publication number: 20230054326Abstract: A probiotic composition for treating rapid eye movement sleep behavior disorder, is prepared from Bacillus licheniformis, Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis, and pharmaceutically acceptable adjuvants. The probiotic composition can improve the symptoms of rapid eye movement sleep behavior disorder of a patient, improve RBD symptoms of idiopathic RBD patients and PD patients, improve the motor symptoms and reduce the daily levodopa equivalent dose in PD patients.Type: ApplicationFiled: October 6, 2022Publication date: February 23, 2023Applicant: BEIJING FRIENDSHIP HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIVERSITYInventors: Houzhen TUO, Yitong DU, Xiaojiao XU, Yue LI, Mingkai ZHANG, Ying CUI, Yun XUE, Dan GAO, Ting GAO, Zhi SHENG
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Patent number: 11545672Abstract: An electrical energy generating device includes an electrical energy generating element, a first container, a second container, and a liquid having positive and negative ions. The electrical energy generating element includes a first porous electrode, an eggshell membrane, and a second porous electrode stacked on each other in that order. The first container is located on a side of the first porous electrode away from the eggshell membrane. The second container is located on a side of the second porous electrode away from the eggshell membrane. The liquid is located in at least one of the first container and the second container, and the liquid is configured to penetrate from one of the first container and the second container to another through the electrical energy generating element.Type: GrantFiled: June 28, 2019Date of Patent: January 3, 2023Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Dan Gao, Chang-Hong Liu, Shou-Shan Fan
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Patent number: 11437628Abstract: A method for generating electrical energy includes providing an electrical energy generating element. The electrical energy generating element includes a first porous electrode, an eggshell membrane, and a second porous electrode stacked on each other in that order. The electrical energy generating element has a first side and a second side opposite to the first side. A liquid having positive ions and negative ions is allowed to penetrate the electrical energy generating element from the first side to the second side.Type: GrantFiled: June 28, 2019Date of Patent: September 6, 2022Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Dan Gao, Chang-Hong Liu, Shou-Shan Fan
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Publication number: 20220193361Abstract: A respiratory mask system is provided. The respiratory mask system has a patient interface that is secured to a user's head by a headgear. The patient interface comprises a seal, a frame and a gas delivery conduit. The frame is configured to secure the seal and gas delivery conduit together. The frame comprises a recessed channel and/or headgear retaining features configured to connect the headgear to the patient interface. The frame can include an inlet collar that connects to a gas delivery conduit. The inlet collar can include bias flow holes. The headgear comprises a top strap, a pair of side arms, a yoke and a rear strap. The yoke is configured to connect to the recessed channel of the frame. The top strap, side arms and yoke form an integrally formed closed loop. The top strap can include two portions adjustably connected to each other.Type: ApplicationFiled: November 17, 2021Publication date: June 23, 2022Inventors: Ryan Anthony Graham, Callum Ross Gordon, Amit Galgali, Mark Andrew Thompson, Bruno Sintive, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira
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Patent number: D963837Type: GrantFiled: December 23, 2019Date of Patent: September 13, 2022Assignee: Fisher & Paykel Healthcare LimitedInventors: Callum Ross Gordon, Ryan Anthony Graham, Bruno Sintive, Mark Andrew Thompson, Amit Galgali, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira
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Patent number: D969993Type: GrantFiled: December 31, 2019Date of Patent: November 15, 2022Assignee: Fisher & Paykel Healthcare LimitedInventors: Callum Ross Gordon, Ryan Anthony Graham, Bruno Sintive, Mark Andrew Thompson, Amit Galgali, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira
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Patent number: D970720Type: GrantFiled: June 24, 2019Date of Patent: November 22, 2022Assignee: Fisher & Paykel Healthcare LimitedInventors: Callum Ross Gordon, Ryan Anthony Graham, Bruno Sintive, Mark Andrew Thompson, Amit Galgali, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira
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Patent number: D1015527Type: GrantFiled: November 11, 2022Date of Patent: February 20, 2024Assignee: Fisher & Paykel Healthcare LimitedInventors: Callum Ross Gordon, Ryan Anthony Graham, Bruno Sintive, Mark Andrew Thompson, Amit Galgali, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira
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Patent number: D1017795Type: GrantFiled: October 17, 2022Date of Patent: March 12, 2024Assignee: Fisher & Paykel Healthcare LimitedInventors: Callum Ross Gordon, Ryan Anthony Graham, Bruno Sintive, Mark Andrew Thompson, Amit Galgali, Vicky Dan Gao, Cameron Robert Willis, Jake Baker Hocking, Priyanka Ferdinand Pereira