Patents by Inventor Dan Grisaru

Dan Grisaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110039791
    Abstract: The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.
    Type: Application
    Filed: September 24, 2010
    Publication date: February 17, 2011
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, Medical Research Fund at the Tel Aviv Sourasky Medical Center
    Inventors: Hermona Soreq, Dan Grisaru, Varda Deutsch, Chava Perry, Marjorie Pick
  • Patent number: 7838493
    Abstract: The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: November 23, 2010
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Medical Research Fund at the Tel Aviv Sourasky Medical Center
    Inventors: Hermona Soreq, Dan Grisaru, Varda Deutsch, Chava Perry, Marjorie Pick
  • Publication number: 20070224181
    Abstract: The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.
    Type: Application
    Filed: February 10, 2005
    Publication date: September 27, 2007
    Inventors: Hermona Soreq, Dan Grisaru, Varda Deutsch, Chava Perry, Marjorie Pick
  • Publication number: 20070065882
    Abstract: The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals.
    Type: Application
    Filed: April 11, 2006
    Publication date: March 22, 2007
    Inventors: Hermona Soreq, Amiram Eldor, Sofia Eldor, Varda Deutsch, Dan Grisaru
  • Patent number: 7067486
    Abstract: The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 27, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Hermona Soreq, Sofia Eldor, legal representative, Varda Deutch, Dan Grisaru, Amiram Eldor, deceased
  • Publication number: 20030036632
    Abstract: The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals.
    Type: Application
    Filed: November 30, 2001
    Publication date: February 20, 2003
    Inventors: Hermona Soreq, Amiram Eldor, Sofia Eldor, Varda Deutch, Dan Grisaru