Patents by Inventor Dan H. Barouch

Dan H. Barouch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant adenoviruses and use thereof
    Patent number: 10781427
    Abstract: The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: September 22, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Washington University
    Inventors: Dan H. Barouch, Herbert Virgin, IV, Peter Abbink
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 10772952
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: September 15, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Stabilized human immunodeficiency virus (HIV) clade C envelope (Env) trimer vaccines and methods of using same
    Patent number: 10716845
    Abstract: The invention features stabilized human immunodeficiency virus (H IV) clade C envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV clade C Env trimers. In addition, the invention features methods of making and using the stabilized HIV clade C Env trimers of the invention.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: July 21, 2020
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan H. Barouch, Christine Bricault
  • ANTIBODY THERAPIES FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV)
    Publication number: 20200129618
    Abstract: This invention relates to antibody therapies for human immunodeficiency virus (HIV). In particular, the invention provides methods of curing subjects infected with HIV and blocking HIV infections in subjects at risk of HIV transmission using a N332 glycan-dependent antibody (e.g., PGT121).
    Type: Application
    Filed: August 8, 2019
    Publication date: April 30, 2020
    Inventor: Dan H. BAROUCH
  • Compositions and methods for preventing and treating Zika virus infection
    Patent number: 10611801
    Abstract: The invention relates to immunogenic compositions and vaccines containing a ZIKV protein or a polynucleotide encoding a Zika virus (ZIKV) protein and uses thereof. The invention also provides methods of treating and/or preventing a ZiKV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: April 7, 2020
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan H. Barouch, Peter Abbink, Rafael Larocca
  • SIGNATURE-BASED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING THE SAME
    Publication number: 20200055901
    Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Application
    Filed: October 17, 2017
    Publication date: February 20, 2020
    Inventors: Dan H. BAROUCH, Christine BRICAULT, Bette T. KORBER, Karina YUSIM
  • Biochemically stabilized HIV-1 env trimer vaccine
    Patent number: 10463729
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: November 5, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
    Publication number: 20190314492
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 17, 2019
    Inventors: Dan H. BAROUCH, Bette T. KORBER, William M. FISCHER
  • Antiviral vaccines with improved cellular immunogenicity
    Patent number: 10426831
    Abstract: The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 1, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., TRIAD NATIONAL SECURITY, LLC
    Inventors: Dan H. Barouch, Bette T. Korber, William M. Fischer
  • Human immunodeficiency virus therapies utilizing N332-glycan-dependent antibodies and a reservoir activator
    Patent number: 10376583
    Abstract: This invention relates to antibody therapies for human immunodeficiency virus (HIV). In particular, the invention provides methods of curing subjects infected with HIV and blocking HIV infections in subjects at risk of HIV transmission using a N332 glycan-dependent antibody (e.g., PGT121).
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: August 13, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventor: Dan H. Barouch
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20190240319
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 8, 2019
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 10307478
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 4, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ZIKA VIRUS INFECTION
    Publication number: 20190144506
    Abstract: The invention relates to immunogenic compositions and vaccines containing a ZIKV protein or a polynucleotide encoding a Zika virus (ZIKV) protein and uses thereof. The invention also provides methods of treating and/or preventing a ZiKV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Application
    Filed: June 9, 2017
    Publication date: May 16, 2019
    Inventors: Dan H. BAROUCH, Peter ABBINK, Rafael LAROCCA
  • RECOMBINANT ADENOVIRUSES AND USE THEREOF
    Publication number: 20190136205
    Abstract: The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
    Type: Application
    Filed: October 12, 2018
    Publication date: May 9, 2019
    Inventors: Dan H. BAROUCH, Herbert VIRGIN, IV, Peter ABBINK
  • STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME
    Publication number: 20190055290
    Abstract: The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
    Type: Application
    Filed: November 1, 2018
    Publication date: February 21, 2019
    Inventors: Dan H. BAROUCH, Joseph Patrick NKOLOLA
  • Stabilized human immunodeficiency virus (HIV) envelope (ENV) trimer vaccines and methods of using same
    Patent number: 10160788
    Abstract: The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: December 25, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Dan H. Barouch, Joseph Patrick Nkolola
  • Recombinant adenoviruses and use thereof
    Patent number: 10106781
    Abstract: The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: October 23, 2018
    Assignees: Beth Israel Deaconess Medical Center, Inc., Washington University
    Inventors: Dan H. Barouch, Herbert Virgin, IV, Peter Abbink
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20180207259
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: March 13, 2018
    Publication date: July 26, 2018
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME
    Publication number: 20180186839
    Abstract: The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
    Type: Application
    Filed: February 15, 2018
    Publication date: July 5, 2018
    Inventors: Dan H. BAROUCH, Joseph Patrick NKOLOLA
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 9950060
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 24, 2018
    Assignees: Beth Israel Deaconess Medical Center, Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkoloa, Michael Scott Seaman