Patents by Inventor Dan Jun Li

Dan Jun Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Membrane bound IL12 compositions and methods for tunable regulation
    Patent number: 12227551
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 18, 2025
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Michelle Lynn Ols, Vipin Suri, Dexue Sun, Dan Jun Li, Dhruv Kam Sethi, Abhishek Kulkarni, Benjamin J. Primack, James Storer
  • COMPOSITIONS AND SYSTEMS FOR REGULATION OF FUNCTION/ABUNDANCE AND DELIVERY OF POLYPEPTIDE PAYLOADS
    Publication number: 20240424136
    Abstract: Provided herein are engineered, regulatable polypeptides comprising a payload and a modulation hub with at least two drug responsive domains (DRD), wherein the modulation hub is operably linked to the payload and wherein the at least two DRDs are responsive to a ligand. Also provided are engineered monomers comprising an oligomerization domain and a payload, a DRD or both a payload and DRD, wherein the monomers are configured to assemble into oligomers by way of the oligomerization domain and the oligomers comprise at least one payload operably linked to a modulation hub. The abundance, availability and/or biological activity of the payload is regulated by interaction of the one or more DRDs and an effective amount of ligand.
    Type: Application
    Filed: October 18, 2022
    Publication date: December 26, 2024
    Applicant: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Dhruv Sethi, Sean Smith, Michelle Ols, Dexue Sun, Dan Jun Li, Jan ter Meulen, Michael Schebesta
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20240401004
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: July 29, 2024
    Publication date: December 5, 2024
    Applicant: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Dan Jun Li, Dexue Sun, Byron DeLaBarre, Vijaya Balakrishnan, Brian Dolinski, Mara Christine Inniss, Grace Y. Olinger
  • DHFR tunable protein regulation
    Patent number: 12104178
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: October 1, 2024
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Dan Jun Li, Dexue Sun, Byron Delabarre, Vijaya Balakrishnan, Brian Dolinski, Mara Christine Inniss, Grace Y. Olinger
  • REGULATED BIOCIRCUIT SYSTEMS
    Publication number: 20230233608
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: August 16, 2022
    Publication date: July 27, 2023
    Applicant: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski
  • PDE5 compositions and methods for immunotherapy
    Patent number: 11666642
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: June 6, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • DHFR tunable protein regulation
    Patent number: 11629340
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: April 18, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Dan Jun Li, Dexue Sun, Byron Delabarre, Vijaya Balakrishnan, Brian Dolinski, Mara Christine Inniss, Grace Y. Olinger
  • TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230092895
    Abstract: The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 23, 2023
    Inventors: Vipin Suri, Michael Joseph Briskin, Brian Dolinski, Kutlu Goksu Elpek, Tucker Ezell, Scott Francis Heller, Mara Christine Inniss, Tariq A. Kassum, Nicole Kosmider, Abhishek Kulkarni, Meghan Langley, Dan Jun Li, Michelle Lynn Ols, Benjamin J. Primack, Celeste Richardson, Steven Mark Shamah, James Storer, Dexue Sun, Vijaya Balakrishnan, Andrew R.M. Bradbury, Michael Frank Erasmus, Fortunato Ferrara
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230074330
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: February 1, 2022
    Publication date: March 9, 2023
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY
    Publication number: 20220403001
    Abstract: The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3?,5?-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 22, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER, Jennifer Leah GORI, Byron DELABARRE
  • Regulated biocircuit systems
    Patent number: 11446398
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 20, 2022
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20220213449
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: December 28, 2021
    Publication date: July 7, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • CD40L COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20220175781
    Abstract: The present disclosure provides regulatable biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 9, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Michael SCHEBESTA, Michelle Lois FLEURY, Kutlu Goksu ELPEK, Elizabeth Jane WEISMAN, Vipin SURI, Dexue SUN, Dan Jun LI, Steven Mark SHAMAH, Michael Joseph BRISKIN, Celeste RICHARDSON, Tariq A. KASSUM, Michelle Lynn OLS, Brian DOLINSKI, Mara Christine INNISS, Emily BRIDEAU, Jennifer Leah GORI, Dhruv Kam SETHI
  • MEMBRANE BOUND IL12 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20220056092
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 24, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Michelle Lynn OLS, Vipin SURI, Dexue SUN, Dan Jun LI, Dhruv Kam SETHI, Abhishek KULKARNI, Benjamin J. PRIMACK, James STORER
  • PDE5 compositions and methods for immunotherapy
    Patent number: 11241485
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: February 8, 2022
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • ER TUNABLE PROTEIN REGULATION
    Publication number: 20210386788
    Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: October 23, 2019
    Publication date: December 16, 2021
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Dexue SUN, Michelle Lynn OLS, Scott Francis HELLER, Dan Jun LI, Celeste RICHARDSON, Mara Christine INNISS, Jennifer Leah GORI, Benjamin J. PRIMACK, Abhishek KULKARNI, Brian DOLINSKI, Tucker Read EZELL, Michael SCHEBESTA, James A. STORER, Kutlu Goksu ELPEK
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20200172879
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: September 2, 2019
    Publication date: June 4, 2020
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20200101142
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: June 12, 2018
    Publication date: April 2, 2020
    Inventors: Vipin SURI, Byron DELABARRE, Michael N. GLADSTONE, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER
  • REGULATED BIOCIRCUIT SYSTEMS
    Publication number: 20190192691
    Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
    Type: Application
    Filed: April 11, 2017
    Publication date: June 27, 2019
    Inventors: Peter Barrett, Michael N. Gladstone, Tariq A. Kassum, Vipin Suri, Dan Jun Li, Dexue Sun, Brian Dolinski